Brain regional development of the activity of α-ketoglutarate dehydrogenase complex in the rat

Developmental Brain Research

Volumn 125, Issue 1-2, 2000, Pages 139-145

  Buerstatte, C R ^a   Behar, K L ^a   Novotny, E J ^a   Lai, J C K ^a  

^a IDAHO STATE UNIVERSITY   (United States)

Author keywords

Brain development; Glucose oxidative metabolism; Thiamine dependent enzyme; Tricarboxylic acid cycle; Ketoglutarate dehydrogenase complex

Indexed keywords

OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE; TRICARBOXYLIC ACID;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; CORPUS STRIATUM; ENERGY METABOLISM; ENZYME ACTIVITY; HYPOTHALAMUS; MESENCEPHALON; NONHUMAN; OLFACTORY BULB; PATHOPHYSIOLOGY; PHYLOGENY; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CITRIC ACID CYCLE; FEMALE; GLUCOSE; KETOGLUTARATE DEHYDROGENASE COMPLEX; MALE; OXIDATION-REDUCTION; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; THIAMINE;

EID: 0034731489     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(00)00134-6     Document Type: Article

References (46)

1. Postnatal development of the complexes of the electron transport chain isolated rat brain mitochondria
2. Development of enzymes of energy metabolism in the brain of a precocial (guinea pig) and non-precocial (rat) species
3. Enzymes of the pyruvate dehydrogenase complex of mammalian brain
4. Pyruvate dehydrogenase activity in regions of the rat brain during postnatal development
5. Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome
6. Development of enzymes of energy metabolism in the neonatal mammalian brain
7. Glycolytic, tricarboxylic acid cycle, and related enzymes in brain
8. Substrate utilization and brain development
9. The pyruvate dehydrogenase complex: Cloning of the rat somatic E1α subunit and its coordinate expression with the mRNAs for the E1β, E2, and E3 catalytic subunits in developing rat brain
10. The developing brain
11. The α-ketoglutarate dehydrogenase complex in neurodegeneration
12. Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits
13. Brain energy metabolizing enzymes in Alzheimer's disease: Alpha-ketoglutarate dehydrogenase complex and cytochrome oxidase
14. Oxidative metabolism in neuronal and non-neuronal mitochondria
15. Liver cirrhosis, fulminant hepatic failure, and hepatocellular carcinoma: Coexistence and a therapeutic nightmare and challenge. Part I. Pathophysiological and pathogenetic mechanisms
16. Glycolysis-citric acid cycle interrelation: A new approach and some insights in cellular and subcellular compartmentation
17. Preparation of synaptic and nonsynaptic mitochondria from mammalian brain
18. Isolation and characterization of synaptic and nonsynaptic mitochondria from brain
19. Brain α-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution, and effects of inhibitors
20. Neurotoxicity of ammonia and fatty acids: Differential inhibition of mitochondrial dehydrogenases by ammonia and fatty acyl coenzyme A derivatives
21. Differences in the neurotoxic effects of manganese during development and aging: Some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy
22. Differential effects of fatty acyl coenzyme A derivatives on citrate synthase and glutamate dehydrogenase
23. Brain mitochondrial citrate synthase and glutamate dehydrogenase: Differential inhibition by fatty acyl coenzyme A derivatives
24. Differential inhibition of mitochondrial dehydrogenases by fatty acyl CoAs
25. Relationship between activation state of pyruvate dehydrogenase complex and rate of pyruvate oxidation in isolated cerebro-cortical mitochondria: Effects of potassium ions and adenine nucleotides
26. Differences in some of the metabolic properties of mitochondria isolated from cerebral cortex and olfactory bulb in the rat
27. Synaptic and non-synaptic mitochondria from rat brain: Isolation and characterization
28. Development of mitochondrial energy metabolism in rat brain
29. Regional enzyme development in rat brain. Enzymes associated with glucose utilization
30. Regional enzyme development in rat brain. Enzymes of energy metabolism
31. Regional development of glutamate dehydrogenase in the rat brain
32. Energy-metabolizing enzymes in brain regions of adult and aging rats
33. Comparative development of the pyruvate dehydrogenase complex and citrate synthase in rat brain mitochondria
34. Effects of lactate on glucose metabolism of developing rat brain
35. Dichloroacetate increases glucose use and decreases lactate in developing rat brain
36. Role of mitochondria in the etiology and pathogenesis of Parkinson's disease
37. Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect; dihydrolipoyl dehydrogenase deficiency
38. Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro
39. Activities of enzyme of ketone body utilization in brain other tissues of suckling rats
40. The α-ketoglutarate dehydrogenase complex
41. Immunochemical characterization of the deficiency of the α-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain
42. b phosphatase in brain: Activity, properties and subcellular localization
43. a) kinase in rat brain
44. Immunochemical characterization of pyruvate dehydrogenase complex in rat brain
45. Lactate utilization by isolated cells from early neonatal rat brain
46. Metabolism of lactate in the rat brain during the early neonatal period