Homeostatic role of the active transport in elimination of [3H]benzylpenicillin out of the cerebrospinal fluid system

Life Sciences

Volumn 67, Issue 19, 2000, Pages 2375-2385

  Casal, J Antonio ^a   Corzo, M Dolores ^b   Pérez, Luis F ^a   Alvarez, J Antonio ^b   Aldegunde, Manuel ^c   Tutor, J Carlos ^a  

^a Instituto de Salud Carlos III   (Spain)

^b Centro de Investigacion Biomedica EuroEspes   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Acidic metabolites; Active transport; Benzylpenicillin; Cerebrospinal fluid

Indexed keywords

PENICILLIN G; PROBENECID; TRITIUM;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CAPILLARY WALL; CISTERNA MAGNA; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DURA MATER; HOMEOSTASIS; NONHUMAN;

ANIMAL; BIOLOGICAL TRANSPORT, ACTIVE; CEREBROSPINAL FLUID; DOGS; MODELS, ANIMAL; PENICILLIN G; PENICILLINS; PROBENECID; SUPPORT, NON-U.S. GOV'T;

EID: 0034730373     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00823-7     Document Type: Article

References (36)

1. Quantitative studies of the passage of different substrates out of the cerebrospinal fluid
2. The third circulation revisted
3. Cerebrospinal fluid circulation and the blood-brain barrier
4. Cerebrospinal fluid: Blood-brain barrier, brain edema, and hydrocephalus
5. Anatomic details of intradural channels in the parasagittal dura: A possible pathway for flow of cerebrospinal fluid
6. The blood-brain barrier and CSF barriers to penicillin and related organic acids
7. The active transport of 5-hydroxyindol-3-ylacetic acid and 3-methoxy-4-hydroxyphenyl-acetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthetized dogs
8. Exchange of 5-hydroxyindoleacetic acid between the spinal cord and lumbar cerebrospinal fluid
9. 3H]benzylpenicillin in the cerebrospinal fluid
10. Homeostatic role of active transport in distribution of substances along cerebrospinal fluid
11. Neurochemical study of the cerebrospinal fluid
12. The diagnostic uses of cerebrospinal fluid
13. Origin of 5-hydroxyindoleacetic acid in the spinal fluid
14. On the cerebral origin of 5-hydroxyindoleacetic acid in the lumbar cerebrospinal fluid
15. Intracranial compartment volumes in patients with enlarged ventricles assessed by magnetic resonance-based image processing
16. 3H]inulin by CSF pulsation and body activity into various compartments of the CSF
17. Neuropathological observation on the cerebrospinal fluid pathway
18. Computer cisternography for evaluation of CSF flow dynamics
19. Dynamics of the cerebrospinal fluid and spinal dura mater
20. Hydrocephalus and CSF pulsatility: Clinical and laboratory studies
21. Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging
22. Normal flow patterns of intracranial and spinal cerebrospinal fluid defined with phase-contrast cine MR imaging
23. Dynamics and statics of the cerebrospinal fluid: The classical and a new hypothesis
24. Experimental hydrocephalus and hydromyelia: A new insight in mechanism of their development
25. Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood
26. Application of steady-state kinetics to study of the transfer of 5-hydroxyindoleacetic acid from brain to plasma
27. Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs
28. Mechanism of 5-hydroxytryptamine penetration through the cerebrospinal fluid - Brain barrier
29. Transport of material between brain extracellular fluid, brain cells and blood
30. A new view on the CSF-circulation with the potential for pharmacological treatment of childhood hydrocephalus
31. Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by rapid distribution of tracer protein throughout the brain from the subarachnoid space
32. Arterial pulsation - Dependent perivascular cerebrospinal fluid flow into central canal in the sheep spinal cord
33. Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives