Synthesis and characterization of oligodeoxynucleotides containing the major DNA adducts formed by 1,6- and 1,8-dinitropyrene

Organic Letters

Volumn 2, Issue 13, 2000, Pages 1871-1874

  Purohit, Vandana ^a   Basu, Ashis K ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DINITROPYRENE; 1,6-DINITROPYRENE; 1,8 DINITROPYRENE; 1,8-DINITROPYRENE; MUTAGENIC AGENT; OLIGODEOXYRIBONUCLEOTIDE; PYRENE DERIVATIVE;

ARTICLE; CHEMISTRY; DNA ADDUCT; DRUG EFFECT; SYNTHESIS;

DNA ADDUCTS; MUTAGENS; OLIGODEOXYRIBONUCLEOTIDES; PYRENES;

EID: 0034729583     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol000090c     Document Type: Article

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33. 6b,c The absence of the singlet representing the C8 proton of guanine at ∼7.9 ppm indicated that this position is the site of adduction. The MS analyses of both standards by ES gave the correct mass of m/z 528 as well as fragmentation peaks of 412 and 366, corresponding to the loss of a sugar and a sugar plus the nitro group, respectively.