Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 379, Issue 1, 1997, Pages 61-68

  Smith, Beverly A ^a   Manjanatha, Mugimane G ^a   Pogribny, Igor P ^a   Mittelstaedt, Roberta A ^a   Chen, Tao ^a   Fullerton, Nancy F ^a   Beland, Frederick A ^a   Heflich, Robert H ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

1,6 Dinitropyrene; Fischer 344 rat; hprt; K ras; Lung tumor; p53

Indexed keywords

1,6 DINITROPYRENE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PROTEIN P53; PYRENE DERIVATIVE; TIOGUANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; LUNG TUMOR; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ANIMALS; CLONE CELLS; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE; EXONS; GENES, P53; GENES, RAS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LUNG NEOPLASMS; MALE; MUTAGENS; POINT MUTATION; PYRENES; RATS; RATS, INBRED F344; T-LYMPHOCYTES; THIOGUANINE;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0030855902     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00107-3     Document Type: Article

References (43)

1. Takayama S., Ishikawa T., Nakajima H., Sato S. Lung carcinoma induction in Syrian golden hamsters by intratracheal instillation of 1,6-dinitropyrene. Jpn. J. Cancer Res. 76:1985;457-461.
2. Maeda T., Izumi K., Otsuka H., Manabe Y., Kinouchi T., Ohnishi Y. Induction of squamous cell carcinoma in the rat lung by 1,6-dinitropyrene. J. Natl. Cancer Inst. 76:1986;693-701.
3. Wislocki P.G., Bagan E.S., Lu A.Y.H., Dooley K.L., Fu P.P., Han-Hsu H., Beland F.A., Kadlubar F.F. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis. 7:1986;1317-1322.
4. Ishizaka Y., Ochiai M., Ohgaki H., Ishikawa F., Sato S., Miura Y., Nagao M., Sugimura T. Active H-ras and N-ras in rat fibrosarcomas induced by 1,6-dinitropyrene. Cancer Lett. 34:1987;317-324.
5. Iwagawa M., Maeda T., Izumi K., Otsuka H., Nishifuji K., Ohnishi Y., Aoki S. Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats. Carcinogenesis. 10:1989;1285-1290.
6. Imaida K., Lee M.-S., Wang C.Y., King C.M. Carcinogenicity of dinitropyrenes in the weanling female CD rat. Carcinogenesis. 12:1991;1187-1191.
7. Smith B.A., Fullerton N.F., Aidoo A., Heflich R.H., Beland F.A. DNA adduct formation in relation to lymphocyte mutations and lung tumor induction in F344 rats treated with the environmental pollutant 1,6-dinitropyrene. Environ. Health Persp. 99:1993;277-280.
8. Beland F.A., Fullerton N.F., Smith B.A., Heflich R.H. Formation of DNA adducts and induction of mutations in rats treated with tumorigenic doses of 1,6-dinitropyrene. Environ. Health Persp. 102(Suppl. 6):1994;185-189.
9. Smith B.A., Fullerton N.F., Heflich R.H., Beland F.A. DNA adduct formation and T-lymphocyte mutation induction in F344 rats implanted with tumorigenic doses of 1,6-dinitropyrene. Cancer Res. 55:1995;2316-2324.
10. Stanley L.A. Molecular aspects of chemical carcinogenesis: the roles of oncogenes and tumour suppressor genes. Toxicology. 96:1995;173-194.
11. Matsumoto K., Tsuda H., Iwase T., Ito M., Nishida Y., Oyama F., Titani K., Ushijima T., Nagao M., Hirono I. Absence of ras family point mutations at codons 12, 13 and 61 in N-ethyl-N-hydroxyethylnitrosamine- or N-nitrosomorpholine-induced renal cell tumors in rats. Jpn. J. Cancer Res. 83:1992;933-936.
12. Hulla J.E., Schneider R.P. Structure of the rat p53 tumor suppressor gene. Nucleic Acids Res. 21:1993;713-717.
13. Orita M., Suzuki Y., Sekiya T., Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics. 5:1989;874-879.
14. Mittelstaedt R.A., Heflich R.H. Analysis of in vivo mutation in exon 8 of the rat hprt gene. Mutation Res. 311:1994;139-148.
15. 1 mice exposed to N-ethyl-N-nitrosourea. Proc. Natl. Acad. Sci. USA. 89:1992;7866-7870.
16. Mittelstaedt R.A., Smith B.A., Heflich R.H. Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes. Environ. Mol. Mutagen. 26:1995;261-269.
17. Heflich R.H., Mittelstaedt R.A., Manjanatha M.G., Lyn-Cook L.E., Aidoo A. DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene. Environ. Mol. Mutagen. 28:1996;5-12.
18. Hollstein M., Sidransky D., Vogelstein B., Harris C.C. p53 mutations in human cancers. Science. 253:1991;49-53.
19. Chen P.-L., Chen Y., Bookstein R., Lee W.-H. Genetic mechanisms of tumor suppression by the human p53 gene. Science. 250:1990;1576-1580.
20. Reichel M.B., Ohgaki H., Petersen I., Kleihues P. p53 mutations in primary human lung tumors and their metastases. Mol. Carcinogen. 9:1994;105-109.
21. Kure E.H., Ryberg D., Hewer A., Phillips D.H., Skaug V., Bæra R., Haugen A. p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels. Carcinogenesis. 17:1996;2201-2205.
22. 1. Mol. Carcinogen. 6:1992;159-172.
23. Ohgaki H., Hard G.C., Hirota N., Maekawa A., Takahashi M., Kleihues P. Selective mutation of codons 204 and 213 of the p53 gene in rat tumors induced by alkylating N-nitroso compounds. Cancer Res. 52:1992;2995-2998.
24. Vancutsem P.M., Lazarus P., Williams G.M. Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen. Cancer Res. 54:1994;3864-3867.
25. Ho Y.-S., Cheng H.-T., Wang Y.-J., Lin J.-K. p53 Gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats. Mol. Carcinogen. 13:1995;182-190.
26. Nickell-Brady C., Hahn F.F., Finch G.L., Belinsky S.A. Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors. Carcinogenesis. 15:1994;257-262.
27. Swafford D.S., Nikula K.J., Mitchell C.E., Belinsky S.A. Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black. Carcinogenesis. 16:1995;1215-1221.
28. Rosenkranz H.S. Revisiting the role of mutagenesis in the induction of lung cancers in rats by diesel emissions. Mutation Res. 303:1993;91-95.
29. Boldt J., Mah M.C.-M., Wang Y.-C., Smith B.A., Beland F.A., Maher V.M., McCormick J.J. Kinds of mutations found when a shuttle vector containing adducts of 1,6-dinitropyrene replicates in human cells. Carcinogenesis. 12:1991;119-126.
30. Rodenhuis S., Slebos R.J.C., Boot A.J.M., Evers S.G., Mooi W.J., Wagenaar S.S., van Bodegom P.C., Bos J.L. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res. 48:1988;5738-5741.
31. Stowers S.J., Glover P.L., Reynolds S.H., Boone L.R., Maronpot R.R., Anderson M.W. Activation of the K-ras protooncogene in lung tumors from rats and mice chronically exposed to tetranitromethane. Cancer Res. 47:1987;3212-3219.
32. D.N. Cooper, M. Krawczak, Human Gene Mutation, BIOS Scientific Publishers, Oxford, 1993, pp. 70-72.
33. A.C. Allison, T. Hovi, R.W.E. Watts, A.D.B. Webster, The role of de novo purine synthesis in lymphocyte transformation, in: K. Elliot and D.W. Fitzsimmonds (Eds.), Purine and Pyrimidine Metabolism, Elsevier, Amsterdam, 1977, pp. 207-224.
34. Strauss G.H., Albertini R.J. Enumeration of 6-thioguanine-resistant peripheral blood lymphocytes in man as a potential test for somatic cell mutations arising in vivo. Mutation Res. 61:1979;353-379.
35. Rosman M., Lee M.H., Creasey W.A., Sartorelli A.C. Mechanisms of resistance to 6-thiopurines in human leukemia. Cancer Res. 34:1974;1952-1956.
36. Davidson J.D., Winter T.S. Purine nucleotide pyrophosphorylases in 6-mercaptopurine-sensitive and -resistant human leukemias. Cancer Res. 24:1964;261-267.
37. Evans H.J., Vijayalaxmi Induction of 8-azaguanine resistance and sister chromatid exchange in human lymphocytes exposed to mitomycin C and X rays in vitro. Nature. 292:1981;601-605.
38. Cariello N.F., Skopek T.R. Analysis of mutations occurring at the human hprt locus. J. Mol. Biol. 231:1993;41-57.
39. IARC, 1,6-Dinitropyrene, in: Diesel and Gasoline Engine Exhausts and Some Nitroarenes, Vol. 46, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Lyon, 1989, pp. 215-230.
40. Albertini R.J., Nicklas J.A., Fuscoe J.C., Skopek T.R., Branda R.F., O'Neill J.P. In vivo mutations in human blood cells: biomarkers for molecular epidemiology. Environ. Health Perspect. 99:1993;135-141.
41. Aidoo A., Lyn-Cook L.E., Mittelstaedt R.A., Heflich R.H., Casciano D.A. Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environ. Mol. Mutagen. 17:1991;141-151.
42. Walker V.E., Skopek T.R. A mouse model for the study of in vivo mutational spectra: sequence specificity of ethylene oxide at the hprt locus. Mutation Res. 288:1993;151-162.
43. Chen T., Mittelstaedt R.A., Heflich R.H. Multiplex PCR for the analysis of deletion mutation in the rat lymphocyte hprt assay. Environ. Mol. Mutagen. 29(Suppl. 28):1997;9.