New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Tetrahedron Letters

Volumn 41, Issue 21, 2000, Pages 4053-4056

  Conti, Paola ^a   Kozikowski, Alan P ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBICYCLO[2.1.1]HEXANE 2,5 DICARBOXYLIC ACID; BICYCLO COMPOUND; GLUTAMATE RECEPTOR AGONIST; HEXANE; METABOTROPIC RECEPTOR; NORBORNANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DIASTEREOISOMER; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; RACEMIC MIXTURE; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0034729319     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00588-8     Document Type: Article

References (15)

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15. 3 and extracted with EtOAc. Flash chromatography on silica gel (hexanes:AcOEt 1:4) gave 26 mg of 12 and 38 mg of 13 (overall yield: 46%). The aminoesters 12 and 13 were treated with 6N HCl at reflux for 4 h to afford the final products ABHxD-I and ABHxD-II, respectively, as hydrochloric acid salts. The spectroscopic data for the final compounds are identical to those previously reported (see Ref. 4).