Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase [2]

Journal of Medicinal Chemistry

Volumn 43, Issue 26, 2000, Pages 4927-4929

  Ohmoto, K ^a   Yamamoto, T ^a   Horiuchi, T ^a   Imanishi, H ^a   Odagaki, Y ^a   Kawabata, K ^a   Sekioka, T ^a   Hirota, Y ^a   Matsuoka, S ^a   Nakai, H ^a   Toda, M ^a   Cheronis, J C ^a   Spruce, L W ^a   Gyorkos, A ^a   Wieczorek, M ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOPYRIMIDINONE ALPHA KETO 1,3,4 OXADIAZOLE; ENZYME INHIBITOR; ONO 6818; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

CHIRALITY; DRUG ACTIVITY; DRUG DESIGN; DRUG FORMULATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LETTER; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG DESIGN; ENZYME INHIBITORS; HAPLORHINI; HUMANS; LEUKOCYTE ELASTASE; OXADIAZOLES; PYRIMIDINONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034727843     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0004087     Document Type: Letter

References (14)

1. Neutrophil proteinases
2. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis
3. Elastase and α-1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome
4. Sputum soluble phase proteins and elastase activity in patients with cystic fibrosis
5. Interactions of granulocyte proteases with inhibitors in rheumatoid arthritis
6. Synthetic inhibitors of elastase
7. Inhibitors of human leukocyte elastase
8. Inhibitors of human neutrophil elastase as a potential treatment for inflammatory diseases
9. Therapeutic promises of leukocyte elastase and macrophage metalloelastase inhibitors for the treatment of pulmonary emphysema
10. Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase
11. Design of orally active, non-peptidic inhibitors of human leukocyte elastase