Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques

Circulation

Volumn 102, Issue 22, 2000, Pages 2680-2686

  Okura, Y ^a   Brink, M ^a   Itabe, H ^a   Scheidegger, K J ^a   Kalangos, A ^a   Delafontaine, P ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Apoptosis; Atherosclerosis; Cells; Lipoproteins; Muscle, smooth

Indexed keywords

OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN BAX; PROTEIN BCL 2;

AGED; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INTIMA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VASCULAR SMOOTH MUSCLE;

EID: 0034727711     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.22.2680     Document Type: Article

References (35)

1. Apoptosis in human atherosclerosis and restenosis
2. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model
3. Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice
4. Apoptosis in the atherosclerotic plaque: Quantitative and qualitative aspects
5. Stability and instability: Two faces of coronary atherosclerosis: The Paul Dudley White Lecture, 1995
6. Macrophages and atherosclerotic plaque stability
7. Molecular bases of the acute coronary syndromes
8. Apoptosis in atherogenesis: Implications for plaque destabilization
9. Role of oxidized low density lipoprotein in atherogenesis
10. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
11. Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
12. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid
13. DNA fragmentation and ultrastructural changes of degenerating cells in atherosclerotic lesions and smooth muscle cells exposed to oxidized LDL in vitro
14. Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages, and fibroblasts
15. Evidence for apoptosis in advanced human atheroma: Colocalization with interleukin-1 beta-converting enzyme
16. Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells
17. Colocalization of CPP-32 with apoptotic cells in human atherosclerotic plaques
18. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques
19. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
20. A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions: Complex formation of oxidized phosphatidylcholines and polypeptides
21. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
22. Foam cell apoptosis and the development of the lipid core of human atherosclerosis
23. Apoptosis in the atherosclerotic plaque: Quantitative and qualitative aspects
24. Biotin- or digoxigenin-conjugated nucleotides bind to matrix vesicles in atherosclerotic plaques
25. Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability
26. Luminal foam cell accumulation is associated with smooth muscle cell death in the intimal thickening of human saphenous vein grafts
27. Apoptosis and related proteins in different stages of human atherosclerotic plaques
28. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
29. Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein down-regulation
30. Measurement by quantitative reverse transcription-polymerase chain reaction of the levels of tumor necrosis factor alpha mRNA in atherosclerotic arteries in Watanabe heritable hyperlipidemic rabbits
31. Transitional features in human atherosclerosis: Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks
32. Human atherosclerosis, III: Immunocytochemical analysis of the cell composition of lesions of young adults
33. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques
34. Immunohistochemical determination of in vivo distribution of BAX, a dominant inhibitor of BCL-2
35. Human atherosclerosis, I: Cell constitution and characteristics of advanced lesions of the superficial femoral artery