Treatment of proximal deep vein thrombosis with a novel synthetic compound (SR90107A/ORG31540) with pure anti-factor Xa activity: A phase II evaluation

Circulation

Volumn 102, Issue 22, 2000, Pages 2726-2731

  Buller, H R ^a   Cariou, R ^a   Gallus, A ^a   Gent, M ^a   Ginsberg, J ^a,a   Prins, M H ^a   Lensing, A ^a   Levi, M ^a   Nurmohammed, N ^a   Hirsh, J ^a   Roberts, R ^a   Ten Cate, J W ^a   Decousus, H ^a   Mismetti, P ^a   Buchmuller, A ^a   Charlet, V ^a   Viallon, A ^a   Van der Meer, J ^a   Meinardi, J R ^a   Meijer, K ^a   Piovella, F ^a   Barone, M ^a   Beltrametti, C ^a   Serafini, S ^a   Kraaijenhagen, R A ^a   Koopman, M M W ^a   Jagt, H H T ^a   Muller, M B R ^a   Van Marwij Kooy, M ^a   Nauta, S ^a   Gallus, A S ^a   Coghlan, D ^a   Rich, C ^a   Prandoni, P ^a   Scudeller, A ^a   Scarano, L ^a   Girolami, A ^a   Baker, R ^a   Tan, E ^a   Cooney, J ^a   Eikelboom, J ^a   Ninet, J ^a   Dolmazon, C ^a   Girard Madoux, M H ^a   Coppere, B ^a   Nenci, G G ^a   Agnelli, G ^a   Falcinelli, F ^a   Morini, M ^a   Raffaele, H S ^a   D'Angelo, A ^a   Crippa, L ^a   Vigano d'Angelo, S ^a   Chong, B ^a   Chestreman, C ^a   Malvin, J ^a   Eisbascher, M ^a   MacGillavry, M R ^a   Brandjes, D P M ^a   Beaumont, J F M ^a   Valdes Olmos, R A ^a   Turpie, A G G ^a   Johnson, J ^a   Nowacki, B ^a   Anderson, D ^a   Pleasance, S ^a   Mitchell, M ^a   Ockelford, P ^a   Bennett, A ^a   Jones, R ^a   Porteous, F ^a   Weitz, J ^a   Kearon, C ^a   Simonneau, G ^a   Parent, F ^a   Douketis, J ^a   Schnurr, T ^a   Hainaut, P ^a   Petit, B ^a   Jaumotte, C ^a   Huisman, M V ^a   Van Poelgeest, M I E ^a   Meinders, A E ^a   Van Oostayen, J A ^a   Beer, J ^a   Lugli, A ^a   Pederiva, S ^a   Brill Edwards, P ^a   Stevens, P ^a   Bassand, J P ^a   Seronde, M F ^a   Kassis, J ^a   Fortin, M ^a   Faivre, R ^a   Petiteau, P Y ^a   Verhaeghe, R ^a   Wells, P ^a   Lewandowski, B ^a   more..

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Anticoagulants; Heparin; Imaging; Thrombosis

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; DALTEPARIN; FONDAPARINUX; LOW MOLECULAR WEIGHT HEPARIN;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MALE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; THROMBOEMBOLISM; THROMBUS; TREATMENT OUTCOME;

EID: 0034727707     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.22.2726     Document Type: Article

References (12)

1. Acenocoumarol and heparin compared with acenocoumarol alone in the initial treatment of proximal-vein thrombosis
2. A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis
3. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home
4. The unique antithrombin III binding domain of heparin: A lead to new synthetic antithrombotics
5. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions
6. Antithrombotic potencies of heparins in relation to their antifactor Xa and antithrombin activities: An experimental study in two models of thrombosis in the rabbit
7. Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia
8. Management of venous thromboembolism
9. Surrogate endpoints for the assessment of efficacy in venous thromboembolism treatment trials
10. Pharmacokinetics and tolerance of the natural pentasaccharide (SR90107A/ORG31540) with high affinity to antithrombin III in man
11. Ventilation-perfusion lung-scanning and the diagnosis of pulmonary-embolism: Improvement of observer agreement by the use of a lung segment reference chart
12. Comparison of perfusion lung scanning and angiography in the estimation of vascular obstruction in acute pulmonary embolism