Evidence of a smaller left hippocampus and left temporal horn in both patients with first episode schizophrenia and normal control subjects

Psychiatry Research - Neuroimaging

Volumn 99, Issue 2, 2000, Pages 93-110

  Niemann, Klaus ^a   Hammers, Alexander ^b   Coenen, Volker Arndt ^b   Thron, Armin ^b   Klosterkötter, Joachim ^c  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Amygdala; Brain asymmetry; Magnetic resonance imaging; Schizophrenia; Temporal lobe

Indexed keywords

ADULT; ARTICLE; BRAIN ASYMMETRY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMETHOD COMPARISON; MALE; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHIZOPHRENIA;

ADULT; AMYGDALA; CEREBRAL VENTRICLES; FUNCTIONAL LATERALITY; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; REPRODUCIBILITY OF RESULTS; SCHIZOPHRENIA; TEMPORAL LOBE;

EID: 0034726587     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4927(00)00059-7     Document Type: Article

References (114)

1. Altshuler L.L., Conrad A.J., Kovelman J.A., Scheibel A.B. Hippocampal pyramidal cell orientation in schizophrenia: A controlled neurohistologic study of the Yakovlev collection. Archives of General Psychiatry. 44:1987;1094-1098.
2. Amaral D.G., Insausti R. Hippocampal formation. Paxinos G. The Human Nervous System. 1990;711-755 Academic Press, San Diego, New York, Boston.
3. Andreasen N.C. Negative symptoms in schizophrenia. Definition and reliability. Archives of General Psychiatry. 39:1982;784-788.
4. Andreasen N.C., Swayze II V.W., Flaum M., Yates W.R., Arndt S., McChesney C. Ventricular enlargement in schizophrenia evaluated with computed tomographic scanning. Archives of General Psychiatry. 47:1990;1008-1015.
5. Andreasen N.C., Arndt S., Cohen G., Alliger R., Swayze II V.W. Correction for head size (Letter). Psychiatry Research: Neuroimaging. 50:1993;283.
6. Arndt S., Cohen G., Alliger R.J., Swayze II V.W., Andreasen N.C. Problems with ratio and proportion measures of imaged cerebral structures. Psychiatry Research: Neuroimaging. 40:1991;79-89.
7. Barta P.E., Pearlson G.D., Powers R.E., Richards S.S., Tune L.E. Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. American Journal of Psychiatry. 147:1990;1457-1462.
8. Barta P.E., Powers R.E., Aylward E.H., Chase G.A., Harris G.J., Rabins P.V., Tune L.E., Pearlson G.D. Quantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls. Psychiatry Research: Neuroimaging. 68:1997;65-75.
9. Bartzokis G., Altshuler L.L., Greider T., Curran J., Keen B., Dixon W.J. Reliability of medial temporal lobe volume measurements using reformatted 3D images. Psychiatry Research: Neuroimaging. 82:1998;11-24.
10. Baumann U., Stieglitz R.D. Evaluation des AMDP-Systems anhand der neueren Literatur (1983-1987). Fortschritte der Neurologie-Psychiatrie. 57:1989;357-373.
11. Becker T., Elmer K., Mechela B., Schneider F., Taubert S., Schroth G., Grodd W., Bartels M., Beckmann H. MRI findings in medial temporal lobe structures in schizophrenia. European Neuropsychopharmacology. 1:1990;83-86.
12. Becker T., Elmer K., Schneider F., Schneider M., Grodd W., Bartels M., Heckers S., Beckmann H. Confirmation of reduced temporal limbic structure volume on magnetic resonance imaging in male patients with schizophrenia. Psychiatry Research: Neuroimaging. 67:1996;135-143.
13. Bhatia S., Bookheimer S.Y., Gaillard W.D., Theodore W.H. Measurement of the whole temporal lobe and hippocampus for MR volumetry: Normative data. Neurology. 43:1993;2006-2010.
14. Bilir E., Craven W., Hugg J., Gilliam F., Martin R., Faught E., Kuzniecky R. Volumetric MRI of the limbic system: Anatomic determinants. Neuroradiology. 40:1998;138-144.
15. Bogerts B., Meertz E., Schonfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Archives of General Psychiatry. 42:1985;784-791.
16. Bogerts B., Ashtari M., Degreef G., Alvir J.M.J., Bilder R.M., Lieberman J.A. Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Research: Neuroimaging. 35:1990;1-13.
17. Braendgaard H., Gundersen H.J.G. The impact of recent stereological advances on quantitative studies of the nervous system. Journal of Neuroscience Methods. 18:1986;39-78.
18. Breier A., Buchanan R.W., Elkashef A., Munson R.C., Kirkpatrick B., Gellad F. Brain morphology and schizophrenia: A magnetic resonance imaging study of limbic prefrontal cortex and caudate structures. Archives of General Psychiatry. 49:1992;921-926.
19. Bronen R.A., Cheung G. MRI of the normal hippocampus. Magnetic Resonance Imaging. 9:1991;497-500.
20. Bronen R.A., Gordon C. Relationship of hippocampus and amygdala to coronal MRI landmarks. Magnetic Resonance Imaging. 9:1991;449-457.
21. Bruton C.J., Crow T.J., Frith C.D., Johnstone E.C., Owens D.G.C., Roberts G.W. Schizophrenia and the brain: A prospective clinico-neuropathological study. Psychological Medicine. 20:1990;285-304.
22. Cavalieri, B., 1635 and 1966. Geometria Degli Indivisibili. Unione Tipografica-Editrice Torinese, Bologna, Torino.
23. Chee M.W.L., Low S., Tan J.S.P., Lim W., Wong J. Hippocampal volumetry with magnetic resonance imaging: A cost-effective validated solution. Epilepsia. 38:1997;461-465.
24. Chua S.E., McKenna P.J. Schizophreniaa brain disease? A critical review of structural and functional cerebral abnormality in the disorder. British Journal of Psychiatry. 166:1995;563-582.
25. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 1969;Academic Press, New York, London.
26. Cohen J. A power primer. Pychological Bulletin. 112:1992;155-159.
27. Cole D.A., Maxwell S.E., Arvey R., Salas E. How the power of MANOVA can both increase and decrease as a function of the intercorrelations among the dependent variables. Psychological Bulletin. 115:1994;465-474.
28. Conrad A.J., Scheibel A.B. Schizophrenia and the hippocampus: The embryological hypothesis extended. Schizophrenia Bulletin. 13:1987;577-587.
29. Cook M.J., Fish D.R., Shorvon S.D., Straughan K., Stevens J.M. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. Brain. 115:1992;1001-1015.
30. Cressie N. Statistics for Spatial Data. 1991;John Wiley & Sons, New York.
31. Crow T.J. Schizophrenia as an anomaly of cerebral asymmetry. Maurer K. Imaging of the Brain in Psychiatry and Related Fields. 1993;3-17 Springer, Berlin, Heidelberg, New York.
32. Crow T.J. Schizophrenia as failure of hemispheric dominance for language. Trends in Neuroscience. 20:1997;339-343.
33. DeLisi L.E., Stritzke P.H., Holan V., Anand A., Boccio A., Kuschner M., Riordan H., McClelland J., VanEyle O. Brain morphological changes in first episode cases of schizophrenia: Are they progressive? Schizophrenia Research. 5:1991;206-208.
34. DeOlmos J.S. Amygdala. Paxinos G. The Human Nervous System. 1990;583-710 Academic Press, Inc, San Diego, New York, Boston.
35. Dilling H., Dittmann V. Die psychiatrische Diagnostik nach der 10. Revision der internationalen Klasifikation der Krankheiten (ICD-10). Nervenarzt. 61:1990;259-270.
36. Duvernoy H.M. The Human HippocampusAn Atlas of Applied Anatomy. 1988;J.F. Bergmann Verlag, München.
37. Duvernoy H.M. The Human Brain. Surface, Three-dimensional Sectional Anatomy and MRI. 1991;Springer, Wien, New York.
38. Dwork A.J. Postmortem studies of the hippocampal formation in schizophrenia. Schizophrenia Bulletin. 23:1997;385-402.
39. Easterbrook P.J., Berlin J.A., Gopalan R., Matthews D.R. Publication bias in clinical research. Lancet. 337:1991;867-872.
40. Ebel R.L. Estimation of the reliability of ratings. Psychometrika. 16:1951;407-424.
41. Ebmeier K.P. Brain imaging and schizophrenia. den Boer J.A., Westenberg H.G.M., van Praag H.M. Advances in the Neurobiology of Schizophrenia. Clinical and Neurobiological Advances in Psychiatry. 1:1995;131-155 John Wiley & Sons, Chichester.
42. Flaum M., Swayze V.W., O'Leary D.S., Yuh W.T.C., Ehrhardt J.C., Arndt S.V., Andreasen N.C. Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. American Journal of Psychiatry. 152:1995;704-714.
43. Free S.L., Bergin P.S., Fish D.R., Cook M.J., Shorvon S.D., Stevens J.M. Methods for normalization of hippocampal volumes measured with MR. American Journal of Neuroradiology. 16:1995;637-643.
44. Fukuzako H., Yamada K., Kodama S., Yonezawa T., Fukuzako T., Takenouchi K., Kajiya Y., Nakajo M., Takigawa M. Hippocampal volume asymmetry and age at illness onset in males with schizophrenia. European Archives of Psychiatry and Clinical Neurosciences. 247:1997;248-251.
45. Geinisman Y., Gundersen H.J.G., van der Zee E., West M.J. Unbiased stereological estimation of the total number of synapses in a brain region. Journal of Neurocytology. 25:1996;805-819.
46. Geinisman Y., Gundersen H.J.G., van der Zee E., West M.J. Towards obtaining unbiased estimates of the total number of synapses in a brain region: Problems of primary and secondary importance. Journal of Neurocytology. 26:1997;711-713.
47. Genton M.G. Spatial breakdown point of variogram estimators. Mathematical Geology. 30:1998;853-871.
48. Genton M.G., Furrer R. Analysis of rainfall data by simple good sense: Is spatial statistics worth the trouble? Journal of Geographical Information Decision Analysis. 2:1998;11-17.
49. Genton M.G. The correlation structure of Matheron's classical variogram estimator under elliptically contoured distributions. Mathematical Geology. 32:2000;127-137.
50. Gertz S.D., Lindenberg R., Piavis G.W. Structural variations in the rostral human hippocampus. 1971;367-376 Hopkins Medical Journal.
51. Geschwind N., Galaburda A.M. Cerebral lateralization. Biological mechanism, associations, and pathology: I. A hypothesis and a program for research. Archives of Neurology. 42:1985;428-459.
52. Gross G., Huber G. Psychopathology of the basic stages of schizophrenia in view of formal thought disturbances. Psychopathology. 18:1985;115-125.
53. Gundersen H.J.G., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. Journal of Microscopy. 147:1987;229-263.
54. Gur R.E., Cowell P., Turetzky B.I., Gallacher F., Cannon T., Biker W., Gur R.C. A follow-up magnetic resonance imaging study of schizophrenia: Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Archives of General Psychiatry. 55:1998;145-152.
55. Haller, J., Botteron, K., Brunsden, B., Sheline, Y., Walkup, R., Black K., Gado, M., Vannier, M., 1999. Hippocampal MR Volumetry. http://www.ibc.wustl.edu/bcl/PR3031/HTML-FILES/IV.B.GLOBUL.Shaped.M
56. Hamer, R.M., 1993. A SAS Macro for Computing Intraclass Correlation Coefficients. Virginia Commonwealth University. http://ewe3.sas.com/techsup/download/stat/intracc.sas
57. Hanke J. Sulcal pattern of the anterior parahippocampal gyrus in the human adult. Annals of Anatomy. 179:1997;335-339.
58. Harrison P.J. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain. 122:1999;593-624.
59. Hasboun D., Chantome M., Zouaoui A., Sahel M., Deladoeuille M., Sourour N., Duyme M., Baulac M., Marsault C., Dormont D. MR determination of hippocampal volume: Comparison of three methods. American Journal of Neuroradiology. 17:1996;1091-1098.
60. Hays W.L. Statistics. 1991;Harcourt Brace College Publishers, Fort Worth.
61. Heckers S., Heinsen H., Heinsen Y.C., Beckmann H. Morphometry of the parahippocampal gyrus in schizophrenics and controls. Some anatomical considerations. Journal of Neural Transmission (General Section). 80:1990;151-155.
62. Heckers S., Heinsen H., Heinsen Y.C., Beckmann H. Limbic structures and lateral ventricle in schizophrenia. A quantitative postmortem study. Archives of General Psychiatry. 47:1991;1016-1022.
63. Hirayasu Y., Shenton M.E., Salisbury D.F., Dickey C.C., Fischer I.A., Mazzoni P., Kisler T., Arakaki H., Kwon J.S., Anderson J.E., Yurgelun-Todd D., Tohen M., McCarley R.W. Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. American Journal of Psychiatry. 155:1998;1384-1391.
64. Honeycutt N.A., Smith C.D. Hippocampal volume measurements using magnetic resonance imaging in normal young adults. Journal of Neuroimaging. 5:1995;95-100.
65. Howard R., Mellers J., Petty R., Bonner D., Menon R., Almeida O., Graves M., Renshaw C., Levy R. Magnetic resonance imaging volumetric measurements of the superior temporal gyrus, hippocampus, parahippocampal gyrus, frontal and temporal lobes in late paraphrenia. Psychological Medicine. 25:1995;495-503.
66. Jack C.R., Twomey C.K., Zinsmeister A.R., Sharbrough F.W., Petersen R.C., Cascino G.D. Anterior temporal lobes and hippocampal formations: Normative volumetric measurements from MR images in young adults. Radiology. 172:1989;549-554.
67. Jackson G.D., Duncan J.S. MRI Neuroanatomy: A New Angle on the Brain. 1996;Churchill Livingstone, New York.
68. Jacobsen L.K., Giedd J.N., Vaituzis A.C., Hamburger S.D., Rajapakse J.C., Frazier J.A., Kaysen D., Lenane M.C., McKenna K., Gordon C.T., Rapoport J.L. Temporal lobe morphology in childhood-onset schizophrenia. American Journal of Psychiatry. 153:1996;355-361.
69. Jeste D.V., Lohr J.B. Hippocampal pathological findings in schizophrenia. A morphometric study. Archives of General Psychiatry. 46:1989;1019-1024.
70. Kates W.R., Abrams M.T., Kaufmann W.E., Breiter S.N., Reiss A.L. Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Research: Neuroimaging. 75:1997;31-84.
71. Kim J.H., Tien R.D., Felsberg G.J., Osumi A.K., Lee N. Clinical significance of asymmetry of the fornix and mamillary body on MR in hippocampal sclerosis. American Journal of Neuroradiology. 16:1995;509-515.
72. Klingler J. Die makroskopische Anatomie der Ammonsformation. Denkschriften der Schweizerischen Naturforschenden Gesellschaft vol. 78(1). 1948;Gebrüder Fretz, Zürich.
73. Klüver H., Barrera E. A method for combined staining of cells and fibers in the nervous system. Journal of Neuropathology and Experimental Neurology. 12:1953;400.
74. Laakso M.P., Juottonen K., Partanen K., Vainio P., Soininen H. MRI volumetry of the hippocampus: The effect of slice thickness on volume formation. Magnetic Resonance Imaging. 15:1997;263-265.
75. Lawrie S.M., Abukmeil S.S. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. British Journal of Psychiatry. 172:1998;100-120.
76. Leibovic K.N. Science of Vision. 1990;Springer, New York.
77. LeMay M. Morphological cerebral asymmetries of modern man, fossil man, and non-human primate. Annals of the New York Academy of Sciences. 280:1976;349-364.
78. Mathalon D.H., Sullivan E.V., Rawles J.M., Pfefferbaum A. Correction for head size in brain-imaging measurements. Psychiatry Research: Neuroimaging. 50:1993;121-139.
79. Murphy G.M. Jr., Inger P., Mark K., Lin J., Morrice W., Gee C., Gan S., Korp B. Volumetric asymmetry in the human amygdaloid complex. Journal für Hirnforschung. 28:1987;281-289.
80. Naidich T.P., Daniels D.L., Haughton V.M., Williams A., Pojunas K., Palacios E. Hippocampal formation and related structures of the limbic lobe: Anatomic-MR correlation. Part 1. Surface features and coronal sections. Radiology. 162:1987;747-754.
81. Naidich T.P., Daniels D.L., Haughton V.M., Williams A., Pech P., Pojunas K., Palacios E. The hippocampal formation and related structures of the limbic lobe: Anatomic-magnetic resonance correlation. Gouaze A., Salamon G. Brain Anatomy and Magnetic Resonance Imaging. 1988;32-64 Springer, Berlin, Heidelberg, New York.
82. Nelson M.D., Saykin A.J., Flashman L.A., Riordan H.J. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: A meta-analytic study. Archives of General Psychiatry. 55:1998;433-440.
83. Niemann K., Spetzger U., Coenen V.A., Hütter B.O., Küker W., von Keyserlingk D.G. Anatomically guided neuronavigation: First experience with the Sulcus Editor. Hellwig D., Bauer B.L. Minimally Invasive Techniques for Neurosurgery. Current Status and Future Perspectives. 1998;215-222 Springer, Berlin, Heidelberg, New York.
84. Oldfield R.C. The assessment and analysis of handedness: The Edinburgh Inventory. Neuropsychologia. 9:1971;97-114.
85. Pearlson G.D., Harris G.J., Powers R.E., Barta P.E., Camargo E.E., Chase G.A., Noga J.T., Tune L.T. Quantitative changes in mesial temporal volume, regional cerebral blood flow, and cognition in Alzheimer's disease. Archives of General Psychiatry. 49:1992;402-408.
86. Pearlson G.D., Barta P.E., Powers R.E., Menon R.R., Richards S.S., Aylward E.H., Federman E.B., Chase G.A., Petty R.G., Tien A.Y. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry. 41:1997;1-14.
87. Reynolds G.P., Czudek C., Andrews H.B. Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia. Biological Psychiatry. 27:1990;1038-1044.
88. Reynolds G.P. The amygdala and the neurochemistry of schizophrenia. Aggleton J. The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. 1992;Wiley-Liss, New York.
89. Roberts N., Garden A.S., Cruz-Orive L.M., Whitehouse G.H., Edwards R.H.T. Estimation of fetal volume by magnetic resonance imaging and stereology. British Journal of Radiology. 67:1994;1067-1077.
90. Robinson W.S. The statistical measurement of agreement. American Sociological Review. 22:1957;17-25.
91. Rosene D.L., van Hoesen G.W. The hippocampal formation of the primate brain. A review of some comparative aspects of cytoarchitecture and connections. Jones E.G., Peters A. Cerebral Cortex. Further Aspects of Cortical Function, Including Hippocampus. 6:1987;345-456 Plenum Press, New York, London.
92. Schmitz C. Towards more readily comprehensible procedures in disector stereology. Journal of Neurocytology. 26:1997;707-710.
93. Schmitz C. Variation of fractionator estimates and its prediction. Anatomy and Embryology. 198:1998;371-397.
94. Shrout P.E., Fleiss J.L. Intraclass correlations: Uses in assessing rater reliability. Psychological Bulletin. 86:1979;420-428.
95. Smith G.N., Iacono W.G. Lateral ventricular size in schizophrenia and choice of control group. Lancet. 1:1986;1450.
96. Soininen H.S., Partanen K., Pitkanen A., Vainio P., Hanninen T., Hallikainen M., Koivisto K., Riekkinen P.J. Sr. Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: Correlation to visual and verbal memory. Neurology. 44:1994;1660-1668.
97. Stephan H. Allocortex. Bargmann W. Handbuch der Mikroskopischen Anatomie des Menschen. 4:1975;Springer, Berlin, Heidelberg, New York.
98. Suddath R.L., Casanova M.F., Goldberg T.E., Daniel D.G., Kelsoe J.R. Jr., Weinberger D.R. Temporal lobe pathology in schizophrenia: A quantitative magnetic resonance imaging study. American Journal of Psychiatry. 146:1989;464-472.
99. Suddath R.L., Christison G.W., Torrey E.F., Casanova M.F., Weinberger D.R. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine. 322:1990;789-794.
100. Supprian Z., Hofmann E. The fornix of the human brain: Evidence of left/right asymmetry on axial MRI scans. Surgical Radiological Anatomy. 19:1997;105-109.
101. Swanson L.W., Petrovich G.D. What is the amygdala? Trends in Neuroscience. 21:1998;323-331.
102. Swayze II V.W., Andreasen N.C., Alliger R.J., Yuh W.T., Ehrhardt J.C. Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biological Psychiatry. 31:1992;221-240.
103. Torres I.J., Flashman L.A., O'Leary D.S., Swayze II V., Andreasen N.C. Lack of an association between delayed memory and hippocampal and temporal lobe size in patients with schizophrenia and healthy controls. Biological Psychiatry. 42:1997;1087-1096.
104. Van Paesschen W., Sisodiya S., Connelly A., Duncan J.S., Free S.L., Raymond A.A., Grunewald R.A., Revesz T., Shorvon S.D., Fish D.R., Stevens J.M., Johnson C.L., Scaravilli F., Harkness W.F.J., Jackson G.D. Quantitative hippocampal MRI and intractable temporal lobe epilepsy. Neurology. 45:1995;2233-2240.
105. Velakoulis D., Pantelis C., McGorry P.D., Dudgeon P., Brewer W., Cook M., Desmond P., Bridle N., Tierney P., Murrie V., Singh B., Copolov D. Hippocampal volume in first-episode psychoses and chronic schizophrenia. A high-resolution magnetic resonance imaging study. Archives of General Psychiatry. 56:1999;133-140.
106. Waldo M.C., Cawtra E., Adler L.E., Dubester S., Staunton M., Nagamoto H., Baker N., Madison A., Simon J., Scherzinger A., Drebing C., Gerhardt G., Freedman R. Auditory sensory gating, hippocampal volume, and catecholamine metabolism in patients with schizophrenia and their siblings. Schizophrenia Research. 12:1994;93-106.
107. Watson C., Andermann F., Gloor P., Jones-Gotman M., Peters T., Evans A., Olivier A., Melanson D., Leroux G. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology. 42:1992;1743-1750.
108. Weis E. Morphometry and magnetic resonance imaging of the human brain in normal controls and Down's syndrome. Anatomical Record. 231:1991;593-598.
109. Winer B.J., Brown D.R., Michels K.M. Statistical Principles in Experimental Design. 3rd ed. 1991;McGraw-Hill, New York.
110. Wittchen H.U., Zaudig M., Schramm E., Spengler P., Mombour W., Klug J., Horn R. Strukturiertes Klinisches Interview für DSM-III-R. 1987;Beltz Verlag, Weinheim.
111. Yeo R.A., Hodde-Vargas J., Hendren R.L., Vargas L.A., Brooks W.M., Ford C.C., Gangestad S., Hart B.L. Brain abnormalities in schizophrenia-spectrum children: Implications for a neurodevelopmental perspective. Psychiatry Research: Neuroimaging. 76:1997;1-13.
112. Yoneda Y., Mori E., Yamashita H., Yamadori A. MRI volumetry of medial temporal lobe structures in amnesia following herpes simplex encephalitis. European Neurology. 34:1994;243-252.
113. Young A.H., Blackwood D.H., Roxborough H., McQueen J.K., Martin M.J., Kean D. A magnetic resonance imaging study of schizophrenia: Brain structure and clinical symptoms. British Journal of Psychiatry. 158:1991;158-164.
114. Zipursky R.B., Marsh L., Lim K.O., De Mendt S., Shear P.K., Sullivan E.V., Murphy G.M., Csernansky J.G., Pfefferbaum A. Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biological Psychiatry. 35:1994;501-516.