Cloning, sequence analysis and expression of the cDNAs encoding the canine and equine homologues of the mouse double minute 2 (mdm2) proto-oncogene

Cancer Letters

Volumn 152, Issue 1, 2000, Pages 9-13

  Nasir, Lubna ^a   Burr, Paul D ^a   McFarlane, Steven T ^a   Gault, Elizabeth ^a   Thompson, Hal ^a   Argyle, David J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Canine; Equine; mdm2; Oncogene

Indexed keywords

COMPLEMENTARY DNA; PROTEIN MDM2; PROTEIN P53;

ARTICLE; DOG; GENE EXPRESSION; HORSE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOGS; HORSES; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; EQUIDAE;

EID: 0034724955     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00427-9     Document Type: Article

References (31)

1. Cahilly-Snyder L., Yang-Feng T., Francke U., George D.L. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat. Cell Mol. Genet. 13:1987;235-244.
2. Fakharzadeh S., Trusko S.P., George D.L. Tumorigenic potential associated with enhanced expression of a gene that is amplified in mouse tumor cell line. EMBO J. 10:1991;1565-1569.
3. Oliner J.D., Kinzler K.W., Meltzer P.S., George D.L., Vogelstein B. Amplification of a gene encoding a p53 associated protein in human sarcomas. Nature. 358:1992;80-83.
4. Momand J., Jung D., Wiczynski S., Niland J. The MDM2 gene amplification database. Nucleic Acids Res. 26:1998;3453-3459.
5. Maki C.G., Huibregtse J.M., Howley P.M. In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res. 56:1996;2649-2654.
6. Chang Y.C., Lee Y.S., Tejima T., Tanaka K., Omura S., Heintz N.H., Mitsui Y., Magae J. Mdm2 and bax, downstream mediators of the p53 response are degraded by the ubiquitin-proteosome pathway. Cell Growth Diff. 9:1998;79-84.
7. Barak Y., Juven T., Haffner R., Oren M. Mdm2 expression is induced by wildtype p53 activity. EMBO J. 12:1993;461-468.
8. Wu X., Bayle J.H., Olson D., Levine A.J. The mdm2-p53 autoregulatory feedback loop. Genes Dev. 7:1993;1126-1132.
9. Momand J., Zambetti G.P., Olson D.C., George D., Levine A.J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 69:1992;1237-1245.
10. Chen J., Marechal V., Levine A.J. Mapping of the p53 and mdm-2 interaction domains. Mol. Cell Biol. 13:1993;4107-4114.
11. Oliner J.D., Pietenpol J.A., Thiagalingam S., Gvuris J., Kinzler K.W., Vogelstein B. Oncoprotein mdm2 conceals the activation domain of tumor suppressor P53. Nature. 362:1993;857-860.
12. Jones S.N., Roe A.E., Donehower L.A., Bradley A. Rescue of embryonic lethality in mdm2-deficient mice by absence of p53. Nature. 378:1995;206-208.
13. de Oca Luna Montes R., Wagner D.S., Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 378:1995;203-206.
14. Nasir L., Reid S.W.J. Nucleotide sequence of exons 5 to 9 of the p53 tumour suppressor gene of the donkey (Equus asinus). DNA Sequence. 6:1995;61-63.
15. Nasir L., Reid S.W.J. Nucleotide sequence of the horse (Equus caballus) p53 tumour suppressor gene. DNA Sequence. 6:1996;185-187.
16. Bucher K., Szalai G., Marti E., Griot-Wenk M.E., Lazary S. Tumour suppressor gene p53 in the horse: identification, cloning, sequencing and a possible role in the pathogenesis of equine sarcoid. Res. Vet. Sci. 61:1996;114-119.
17. Nasir L., Argyle D.J., McFarlane S.T., Reid S.W.J. Nucleotide sequence of a highly conserved region of the canine p53 tumour suppressor gene. DNA Sequence. 8:1997;83-86.
18. Veldhoen N., Milner J. Isolation of canine p53 cDNA and detailed characterisaton of the full length canine p53 protein. Oncogene. 16:1998;1077-1084.
19. Devilee P., Van Leeumen S., Voesten A., Rutteman G.R., Vos J.H., Cornelisse C.J. The canine p53 gene is subject to somatic mutations in thyroid carcinoma. Anticancer Res. 14:1994;2039-2046.
20. Mayr B., Schellander K., Schleger W., Reifinger M. Sequence of an exon of the canine p53 gene-mutation in a papilloma. Br. Vet. J. 150:1994;81-84.
21. Mayr B., Schaffner W., Botto I., Reifinger M., Loupal G., anine C. tumour suppressor gene p53-mutation in a case of adenoma of circumanal glands. Vet. Res. Commun. 21:1997;369-373.
22. Van Leeuwen I.S., Cornelisse C.J., Misdorp W., Goedegebuure S., Kirpensteijn J., Rutteman G.R. gene mutations in osteosarcoma in the dog. Cancer Lett. 111:1997;173-178.
23. Nasir L., Argyle D.J. Mutational analysis of the tumour suppressor gene (p53) in two cases of lymphosarcoma in the Bull Mastiff. Vet. Rec. 1999;. in press.
24. Pazzi K.A., Kraegel S.A., Griffey S.M., Theon A.P., Madewell B.R. Analysis of the equine tumor suppressor gene p53 in the normal horse and in eight cutaneous squamous cell carcinomas. Cancer Lett. 107:1996;125-130.
25. Chang K., Lanconi S., Mangold K.A., Hubchak S., Scarpelli D.G. Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas. Cancer Res. 55:1995;2560-2568.
26. Marechal V., Elenbaas B., Taneyhill L., Piette J., Mechali M., Nicolas J.C., Levine A.J., Moreau J. Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis. Oncogene. 14:1997;1427-1433.
27. Martin K., Trouche D., Hagemeier C., Sorensen T.S., LaThangue N.B., Kouzarides T. Stimulation of E2F1/DP1 transcriptional activity by mdm2 oncoprotein. Nature. 375:1995;691-694.
28. Marechal V., Elenbaas B., Piette J., Nicolas J.C., Levine A.J. The ribosomal L5 protein is associated with MDM2 and MDM2-p53 complexes. Mol. Cell. Biol. 14:1994;7414-7420.
29. Elenbaas B., Dobbelstein M., Roth J., Shenk T., Levine A.J. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med. 2:1996;439-451.
30. Boddy M.N., Freemont P.S., Borden K.L.B. The p53-associated protein mdm2 contains a newly characterised zinc-binding domain called the RING finger. Trends Biochem. Sci. 19:1994;198-199.
31. Burr P.D., Argyle D.J., Reid S.W.J., Nasir L. Nucleotide sequence of the porcine p53 cDNA and the detection of recombinant porcine p53 expressed in vitro with a variety of anti-p53 antibodies. Oncogene. 1999;. in press.