Selection of amino acid substitutions restoring activity of HIV-1 integrase mutated in its catalytic site using the yeast Saccharomyces cerevisiae

Journal of Molecular Biology

Volumn 295, Issue 4, 2000, Pages 755-765

  Parissi, Vincent ^a   Caumont, Anne B ^a   De Soultrait, Vaea Richard ^a   Calmels, Christina ^a   Pichuantes, Sergio ^b   Litvak, Simon ^a   Dupont, Charles Henri ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cell lethality; HIV 1; Integrase; Random mutagenesis; Yeast

Indexed keywords

INTEGRASE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CELL KILLING; CELL SURVIVAL; DNA INTEGRATION; GENE SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVIRUS; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; VIRUS REPLICATION;

SACCHAROMYCES CEREVISIAE;

EID: 0034723151     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3416     Document Type: Article

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