Are pigs transgenic for human complement regulatory proteins necessary for xenotransplantation

Transplantation

Volumn 70, Issue 4, 2000, Pages 567-568

  Loveland, Bruce E ^a   Cooper, David K C ^b   Sandrin, Mauro S ^a  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; MEMBRANE COFACTOR PROTEIN;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN EXPRESSION; AORTA; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; CONTROLLED STUDY; CYTOLYSIS; ENDOTHELIUM CELL; IMMUNOLOGICAL TOLERANCE; NONHUMAN; NOTE; PRIORITY JOURNAL; SWINE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

EID: 0034721343     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200008270-00004     Document Type: Note

References (5)

1. Purification and characterization of the pig analogue of human membrane cofactor protein (CD46/MCP)
2. Different membrane cofactor protein (CD46) isoforms protect transfected cells against antibody and complement mediated lysis
3. Transgenic expression of a CD46 (membrane cofactor protein) minigene: Studies of xenotransplantation and measles virus infection
4. Xenotransplantation: State of the art - Update 1999
5. Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis