Redefined substrate specificity of ST6GalNAc II: A second candidate sialyl-Tn synthase

Biochemical and Biophysical Research Communications

Volumn 272, Issue 1, 2000, Pages 94-97

  Kono, Mari ^a,d   Tsuda, Tetsuro ^b   Ogata, Shunichiro ^c   Takashima, Shou ^a,e   Liu, Hong ^a,f   Hamamoto, Toshiro ^a,g   Itzkowitz, Steven H ^c   Nishimura, Shinichiro ^b   Tsuji, Shuichi ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c MOUNT SINAI MEDICAL CENTER   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^f GEORGETOWN UNIVERSITY   (United States)

^g JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Sialyl Tn; Sialyltransferase; ST6GalNAc I; ST6GalNAc II

Indexed keywords

ANTIGEN; ASIALOFETUIN; MUCIN; OLIGOSACCHARIDE; POLYMER; SIALOPROTEIN; SIALYLTRANSFERASE; SYNTHETASE;

ANIMAL CELL; ARTICLE; CARBOHYDRATE ANALYSIS; CARBOHYDRATE SYNTHESIS; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; SUBMANDIBULAR GLAND;

ANIMALIA; OVIS;

EID: 0034720478     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2745     Document Type: Article

References (19)

1. Tsuji, S., Datta, A. K., and Paulson, J. C. (1996) Systematic nomenclature for sialyltransferases. Glycobiology 6 (7), v-vii.
2. Itzkowitz, S. H., Yuan, M., Montgomery, C. K., Kjeldsen, T., Takahashi, H. K., Bigbee, W. L., and Kim, Y. (1989) Expression of Tn, sialosyl-Tn and T antigens in human colon cancer. Cancer Res. 49, 197-204.
3. Saitoh, O., Gallagher, R. E., and Fukuda, M. (1991) Expression of aberrant O-glycans attached to leukosialin in differentiation-deficient HL-60 cells. Cancer Res. 51, 2854-2862.
4. Kurosawa, N., Hamamoto, T., Lee, Y.-C., Nakaoka, T., Kojima, N., and Tsuji, S. (1994) Molecular cloning and expression of GalNAc α2,6-sialyltransferase. J. Biol. Chem. 269, 1402-1409.
5. Kurosawa, N., Kojima, N., Inoue, M., Hamamoto, T., and Tsuji, S. (1994) Cloning and expression of Galβ1,3GalNAc-specific Gal-NAc α2,6-sialyltransferase. J. Biol. Chem. 269, 19048-19053.
6. Kurosawa, N., Takashima, S., Kono, M., Ikehara, Y., Inoue, M., Tachida, Y., Narimatsu, H., and Tsuji, S. (2000) Molecular cloning and genomic analysis of mouse GalNAc α2,6-sialyltransferase (ST6GalNAc I). J. Biochem. 127, in press.
7. Kurosawa, N., Inoue, M., Yoshida, Y., and Tsuji, S. (1996) Molecular cloning and genomic analysis of mouse Gal/β1,3GalNAc-specific GaINAc α2,6-sialyltransferase. J. Biol. Chem. 271, 15109-15116.
8. Lee, Y.-C., Kaufmann, M., Kitazume-Kawaguchi, S., Kono, M., Takashima, S., Liu, H., Kurosawa, N., Pircher, H., and Tsuji, S. (1999) Molecular cloning and functional expression of two members of mouse NeuAcα2,3Galβ1,3GalNAc GalNAcα2,6-sialyltransferase family, ST6GalNAc III and IV. J. Biol. Chem. 274, 11958-11967.
9. Okajima, T., Fukumoto, S., Ito, H., Kiso, M., Hirabayashi, Y., Urano, T., Furukawa, K., and Furukawa, K. (1999) Molecular cloning of brain-specific GD1α synthase (ST6GalNAc V) containing CAG/glutamine repeats. J. Biol. Chem. 274, 30557-30562.
10. Ikehara, Y., Shimizu, N., Kono, M., Nishihara, S., Nakanishi, H., Kitamura, T., Narimatsu, H., Tsuji, S., and Tatematsu, M. (1999) A novel glycosyltransferase with a polyglutamine repeat; A new candidate for GD1α synthase (ST6GalNAc V). FEBS Lett. 463, 92-96.
11. Sjoberg, E. R., Kitagawa, H., Glushka, J., van Halbeek, H., and Paulson, J. C. (1996) Molecular cloning of a developmentally regulated N-acetylgalactosamine α2,6-sialyltransferase specific for sialylated glycoconjugates. J. Biol. Chem. 271, 7450-7459.
12. Ikehara, Y., Kojima, N., Kurosawa, N., Kudo, T., Kono, M., Nishihara, S., Issiki, S., Morozumi, K., Itzkowitz, S., Tsuda, T., Nishimura, S., Tsuji, S., and Narimatsu, H. (1999) Cloning and expression of a human gene encoding an N-acetylgalactosamine-α2,6-sialyltransferase (ST6GalNAc I): A candidate for synthesis of cancer-associated sialyl-Tn antigens. Glycobiology 9, 1213-1224.
13. Okajima, T., Chen, H.-H., Ito, H., Kiso, M., Tai, T., Furukawa, K., Urano, T., and Furukawa, K. (2000) Molecular cloning and expression of mouse GD1a/GT1aa/Gq1ba synthase (ST6GalNAc VI) gene. J. Biol. Chem. 275, 6717-6723.
14. Tetsuro Tsuda and Shin-Ichiro Nishimura (1996) Synthesis of an antifreeze glycoprotein analogue: Efficient preparation of sequential glycopeptide polymers. Chem. Commun. 2779-2780.
15. Tettamanti, G., and Pigman, W. (1968) Purification and characterization of bovine and ovine submazillary mucins. Arch. Biochem. Biophys. 124, 41-50.
16. Kono, M., Yoshida, Y., Kojima, N., and Tsuji, S. (1996) Molecular cloning and expression of a fifth-type of α2,8-sialyltransferase (ST8Sia V): Its substrate specificity is similar to that of SAT-V/ III, which synthesize GD1c, GT1a, GQ1b and GT3. J. Biol. Chem. 271, 29366-29371.
17. Gottschalk, A., and Bhargava, A. S. (1972) in Glycoproteins: Their Composition, Structure and Function (Gottschalk, A., Ed.) Elsevier, New York.
18. Kushima, R., Jancic, S., and Hattori, T. (1993) Association between expression of sialosyl-Tn antigen and intestinalization of gastric carcinomas. Int. J. Cancer 55, 904-908.
19. Itzkowitz, S. H., Bloom, E. J., Kokal, W. A., Modin, G., Hakomori, S., and Kim, Y. S. (1990) Sialosyl-Tn: A novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer 66, 1960-1966.