A comparison of fetal and adult porcine islets with regard to Galα (1,3)Gal expression and the role of human immunoglobulins and complement in islet cell cytotoxicity

Transplantation

Volumn 69, Issue 8, 2000, Pages 1711-1717

  Bennet, William ^a   Björkland, Anna ^c   Sundberg, Berit ^a   Davies, Hugh ^b   Liu, Jining ^a   Holgersson, Jan ^a   Korsgren, Olle ^c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Imutran Ltd (A Novartis Pharma AG Company)   (United Kingdom)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C3C; IMMUNOGLOBULIN;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; FETUS; FETUS CELL; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOTRANSPLANTATION;

EID: 0034720046     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200004270-00030     Document Type: Article

References (20)

1. Gala(1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies
2. Discordant cellular xenografts revascularized in intermediate athymic hosts fail to induce a hyperacute rejection when transplanted to immunocompetent rats
3. Functional and morphological differentiation of fetal porcine islet-like cell clusters after transplantation into nude mice
4. Isolation of the elusive pig islet
5. Transplantation of porcine fetal pancreas to diabetic patients
6. A method for the mass isolation of islets from the adult pig pancreas
7. Large-scale production of fetal porcine pancreatic islet-like cell clusters: An experimental tool for studies of islet cell differentiation and xenotransplantation
8. Preparation of suspensions of pancreatic islet cells: A comparison of methods
9. Removal of xenoreactive human anti-pig antibodies by absorption on recombinant mucin-containing glycoproteins carrying the Gala1,3Gal epitope
10. Production and purification of Fab' fragments from chicken egg yolk immunoglobulin Y (IgY)
11. Expression of Gala(1,3)Gal by porcine islet cells and its relevance to xenotransplantation
12. Expression of Gal alpha(1,3)gal on neonatal porcine islet beta-cells and susceptibility to human antibody/complement lysis
13. Anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters
14. Immunochemical studies of the combining sites of two isolectins A4 and B4 isolated from Bandeiraea simplicifolia
15. A sensitive assay for measuring alpha-Gal epitope expression on cells by a monoclonal anti-Gal antibody
16. Hyperacute xenograft rejection in the swine-to-human donor-recipient combination: In vitro analysis of complement activation
17. Immunohistochemical studies of complement activation after xenogeneic perfusion of working heart model
18. Human complement activation via the alternative pathway on porcine endothelium initiated by IgA antibodies
19. Pig islet xenografts are susceptible to 'anti-pig' but not Gal alpha(1,3)Gal antibody plus complement in Gal o/o mice
20. Human natural antibodies cytotoxic to pig embryonic brain cells recognize novel non-Gal alpha 1,3 Gal-based xenoantigens