The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-α

Experimental Cell Research

Volumn 261, Issue 1, 2000, Pages 239-249

  Clarke, H ^a   Ginanni, N ^a   Laughlin, K V ^a   Smith, J B ^b   Pettit, G R ^c   Mullin, J M ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b University of Alabama at Birmingham   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Phorbol ester; TPA; Transepithelial permeability; Tumor promoter

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BRYOSTATIN 1; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME LOCALIZATION; GENE EXPRESSION; MAMMAL CELL; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; TIGHT JUNCTION; TUMOR GROWTH;

ANIMALIA; MAMMALIA;

EID: 0034715892     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5035     Document Type: Article

References (58)

1. Protein kinase C and lipid signaling for sustained cellular responses
2. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
3. Differential recovery of protein kinase C-α and -ε isozymes after long-term phorbol ester treatment in rat mesangial cells
4. Effect of tumor promoting phorbol ester thrombin and vasopressin on translocation of three distinct protein kinase C isoforms in human platelets and regulation by calcium
5. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
6. Tumor promoter-induced changes in the permeability of epithelial tight junctions and transepithelial fluxes
7. The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells
8. Regulation of vascular endothelial barrier function
9. Reversible disassembly of an intestinal epithelial monolayer by prolonged exposure to phorbol ester treatment
10. Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C
11. Effect of tumor promoters on LLC-PK1 renal epithelial tight junctions and transepithelial fluxes
12. Effects of diacylglycerols on LLC-PK1 renal epithelia: Similarity to phorbol ester tumor promoters
13. The protein kinase C inhibitor, bisindolylmaleimide, inhibits the TPA-induced but not the TNF-induced increase in LLC-PK1 transepithelial permeability
14. Structure, function, and regulation of cellular tight junctions
15. Tight junctions and the molecular basis for regulation of paracellular permeability
16. Protein kinase C in signal transduction and carcinogenesis
17. Tumor promoters and the mechanism of tumor promotion
18. Protein kinase C activation increases transepithelial transport of biologically active insulin
19. Overexpression of the alpha-type protein kinase (PKC) in LLC-PK1 cells does not lead to a proportional increase in the induction of two 12-O-tetradecanoylphorbol-13-acetate-inducible genes
20. Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines
21. Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation
22. Translocation and down-regulation of protein kinase C isoenzymes-alpha and -epsilon by phorbol ester and bryostatin-1 in human keratinocytes and fibroblasts
23. Comparison of different tumor promoters and bryostatin 1 on protein kinase C activation and down-regulation in rat renal mesangial cells
24. Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cells
25. Effects of acute vs. chronic phorbol ester exposure on transepithelial permeability and epithelial morphology
26. 1 epithelial cell line
27. Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester induced differentiation of human promyelocytic leukemia cells HL-60
28. Bryostatins: Potent, new mitogens that mimic phorbol ester tumor promoters
29. Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads Memorial Award Lecture
30. Bryostatin 1: Differentiating agent from the depths
31. Bryostatin 1 induces biphasic activation of protein kinase D in intact cells
32. Dephosphorylation of protein kinase C contributes to downregulation by bryostatin
33. Inhibition of bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells
34. Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells
35. The origin and characteristics of a pig kidney cell strain, LLC-PK1 epithelial cell line
36. Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-α expression and localization
37. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
38. Molecular and catalytic properties of protein kinase C
39. Protein kinase C: Structure, function, and regulation
40. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
41. Down-regulation of protein kinase C is due to an increased rate of degradation
42. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
43. Identification of isoforms of G proteins and PKC that colocalize with tight junctions
44. Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ
45. The relationship between structure and function of tight junctions
46. Electrophysiological methods in the study of water transport across cell membranes
47. Effects of bryostatin 1, a novel anticancer agent, on intestinal transport and barrier function: Role of protein kinase C
48. Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol ester in SEN-CAR mouse skin
49. Bryostatins mimic the effects of phorbol esters in intact human platelets
50. Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C
51. Ubiquitination of protein kinase C-alpha and degradation by the proteasome
52. Transepithelial paracellular leakiness induced by chronic phorbol ester exposure correlates with polyp-like foci and redistribution of protein kinase C-alpha
53. Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain)
54. Protein kinase C V3 domain mutants with differential sensitivities to m-calpain are not resistant to phorbol-ester-induced down-regulation
55. Protein kinase C (PKC)-induced PKC down-regulation with up-regulation of vesicle traffic
56. Calpain: New perspectives in molecular diversity and physiological-pathological involvement
57. Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities
58. Inhibition of membrane lipid-independent protein kinase C-alpha activity by phorbol esters, diacylglycerols, and bryostatin-1