Transdermal nicotine inhibits interleukin 2 synthesis by mononuclear cells derived from healthy volunteers

European Journal of Clinical Investigation

Volumn 28, Issue 8, 1998, Pages 664-671

  Van Dijk, A P M ^a,b   Meijssen, M A C ^b   Brouwer, A J B W ^a   Hop, W C J ^a   Van Bergeijk, J D ^b   Feyerabend, C ^c   Wilson, J H P ^b   Zijlstra, F J ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c New Cross Hospital ^*  (United Kingdom)

Author keywords

Cytokines; Human peripheral lymphocytes; Nicotine

Indexed keywords

COTININE; ICOSANOID; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; NICOTINE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; MONONUCLEAR CELL; NAUSEA; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSDERMAL DRUG ADMINISTRATION; VERTIGO; VOLUNTEER; VOMITING;

ADMINISTRATION, CUTANEOUS; ADULT; ANTI-INFLAMMATORY AGENTS; COTININE; DINOPROSTONE; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-13; INTERLEUKIN-2; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; LEUKOTRIENE B4; MALE; MIDDLE AGED; NICOTINE; NICOTINIC AGONISTS; PHYTOHEMAGGLUTININS; SMOKING CESSATION; THROMBOXANE B2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031851181     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1998.00344.x     Document Type: Article

References (43)

1. Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT. Interleukin-2-and interferon-γ-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993; 78: 127-31.
2. Niessner M, Volk BA. Altered Th11/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101: 428-435.
3. Sartor RB. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 1994; 106:533-9.
4. Radford-Smith G, Jewell DP. The role of cytokines in inflammatory bowel disease. Med Inflammation 1994; 3: 3-9.
5. Harries AD, Baird A, Rhodes J. Non-smoking: a feature of ulcerative colitis. BMJ 1982; 284: 706.
6. Calkins BM. A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 1989; 34: 1841-54.
7. Cottone M, Rosselli M, Orlando A et al. Smoking habits and recurrence in Crohn's disease. Gastroenterology 1994; 106: 643-8.
8. Srivastava ED, Russell MAH, Feyerabend C, Williams GT, Masterson JG, Rhodes J. Transdermal nicotine in active ulcerative colitis. Eur J Gastroenterol 1991; 3: 815-8.
9. Pullan RD, Rhodes J, Ganesh S et al. Transdermal nicotine for active ulcerative colitis. N Engl J Med 1994; 330: 811-5.
10. Sandborn WJ, Tremaine WJ, Offord KP et al. Transdermal nicotine for mildly to moderate active ulcerative colitis. Ann Intern Med 1997; 126: 364-71.
11. Saareks V, Riutta A, Mucha I, Alanko J, Vapaatalo H. Nicotine and cotinine modulate eicosanoid production in human leukocytes and platelet rich plasma. Eur J Pharmacol 1993; 248: 345-9.
12. Zijlstra FJ, Srivastava ED, Rhodes M et al. J. Effect of nicotine on rectal mucus and mucosal eicosanoids. Gut 1994; 35: 247-51.
13. Dijk van JPM, Madretsma GS, Keuskamp ZJ, Zijlstra FJ. Nicotine inhibits cytokine production by mouse colonie mucosa. Eur J Pharmacol 1995; 278: R11-R12.
14. Cope GF, Heatley RV, Kelleher J. Smoking and colonie mucus in ulcerative colitis. BMJ 1986; 293: 481.
15. Srivastava ED, Russell MAH, Feyerabend C, Rhodes J. Effect of ulcerative colitis and smoking on rectal blood flow. Gut 31: 1021-4.
16. Hersey P, Prendergast D, Edwards A. Effects of cigarette smoking on the immune system. Med J Aust 1983; 2: 425-9.
17. Mill F, Flanders WD, Boring JR, Annest JL, Destefano F. The associations of race, cigarette smoking, and smoking cessation to measures of the immune system in middle-aged men. Clin Immunol Immunopathol 1991; 59: 187-200.
18. Srivastava ED, Barton JR, O'Mahony S et al. Smoking, humoral immunity, and ulcerative colitis. Gut 1991; 32: 1016-9.
19. Fischer A, König W. Modulation of in vitro immunoglobulin synthesis of human peripheral blood mononuclear cells by nicotine and cotinine. Clin Invest 1994; 72: 225-32.
20. Feyerabend C, Russell MAH. A rapid gas-liquid chromatographic method for the determination of nicotine and cotinine in biological fluids. J Pharm Pharmacol 1990; 42: 420-52.
21. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 21: 77-85.
22. Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SP. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992; 102: 1620-7.
23. Mullin GE, Vezza FR, Sampat A et al. Abnormal IL-10 mRNA production in the intestinal mucosal lesions of inflammatory bowel disease. Gastroenterology 1993; 104: A751.
24. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989; 7: 145-73.
25. Madretsma GS, Donze GJ, Dijk van APM, Tak CJAM, Wilson JHP, Zijlstra FJ. Nicotine inhibits the in vitro production of interleukin 2 and tumor necrosis factor a by human mononuclear cells. Immunopharmacology 1996; 35: 47-51.
26. Elsässer-Beile U, Kleist von S, Gerlach S, Gallati H, Schulte Mönting J. Cytokine production in whole blood cell cultures of patients with crohn's disease and ulcerative colitis. J Clin Lab Anal 1994; 8: 447-51.
27. Zijlstra FJ, Vincent JE, Mol WM et al. Eicosanoid levels in bronchoalveolar lavage fluid of young smokers and nonsmokers. Eur J Clin Invest 1992; 22: 301-6.
28. 4 is measurable in serum of smokers and nonsmokers. Clin Chem 1989; 35: 459-60.
29. Seow WK, Thong YH, Nelson RD, Macfarlane GD, Herzberg MC. Nicotine-induced release of elastase and eicosanoids by human neutrophils. Inflammation 1994; 18: 119-27.
30. Goerig M, Ullrich V, Schettler G, Foltis C, Habenicht A. A new role for nicotine: selective inhibition of thromboxane formation by direct interaction with thromboxane synthase in human promyelocytic leukaemia cells differentiating into macrophages. Clin Invest 1992; 70: 239-43.
31. Benowitz NL, Fitzgerald GA, Wilson M, Zhang A. Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. J Am Coll Cardiol 1993; 22: 1159-67.
32. Billimoria JD, Pozner H, Metselaar B, Best FW, James DCO. Effect of cigarette smoking on lipids, lipoproteins, blood coagulation, fibrinolysis and cellular components of human blood. Atherosclerosis 1975; 21: 61-76.
33. Petitti DB, Kipp H. The leukocyte count: associations with intensity of smoking and persistence of effect after quitting. Am J Epidemiol 1986; 123: 89-95.
34. Yarnell JWG, Sweetnam Rogers S. Some long-term effects of smoking on the haemostatic system: a report from the Caerphilly and Speedwell Collaborative system. J Clin Pathol 1987; 40: 909-13.
35. Pérez-Stable EJ, Benowitz NL, Marin G. Is serum a better measure of cigarette smoking than self-report. Prev Med 1995; 24: 171-9.
36. Green MS, Harari G. A prospective study of the effects of changes in smoking habits on blood count, serum lipids and lipoproteins, body weight and blood pressure in occupationally active men. The Israeli cordis study. J Clin Epidemiol 1995; 48: 1159-66.
37. Eisen ME, Hammond EC. The effect of smoking on packed cell volume, red blood cell counts, haemoglobin and platelet counts. Can Med Assoc J 1956; 75: 520-3.
38. Belch JJF, McArdle BM, Burns P, Lowe GDO, Forbes CD. The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers. Thromb Haemost 1984; 51: 6-8.
39. Netscher DT, Wigoda P, Thornby J, Yip B, Rappaport NH. The hemodynamic and hematologic effects of cigarette smoking versus a nicotine patch. Plast Reconstr Surg 1995; 96: 681-8.
40. Porchett HC, Benowitz NL, Sheiner LB, Copeland JR. Apparent tolerance to the acute effect of nicotine results in part from distribution kinetics. J Clin Invest 1987; 80: 1466-71.
41. Benowitz NL, Jacob HIP, Fong I, Gupta S. Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 1994; 268: 296-303.
42. Madretsma GS, Dijk van APM, Tak CJAM, Donze GJ, Wilson JHP, Zijlstra FJ. Nicotine inhibits the production of IL-2 and TNFa by peripheral blood and intestinal mononuclear cells. Gastroenterology 1995; 108: A867.
43. Wright SC, Zhong J, Zheng H, Larrick JW. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB 1993; 7: 1045-51.