Neutrophil elastase inhibitor, ONO-5046 suppresses ozone-induced airway mucus hypersecretion in guinea pigs

European Journal of Pharmacology

Volumn 390, Issue 1-2, 2000, Pages 197-202

  Nogami, Hiroko ^a,b   Aizawa, Hisamichi ^c   Matsumoto, Koichiro ^a   Nakano, Hiroyuki ^a   Koto, Hiroshi ^a   Miyazaki, Hiroyuki ^a   Hirose, Takahito ^b   Nishima, Sankei ^b   Hara, Nobuyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Natl Minami Fukuoka Chest H   (Japan)

^c Clinical Research Institute   (Japan)

Author keywords

Goblet cell hypersecretion; Mucus score; Neutrophil elastase inhibitor; Ozone exposure

Indexed keywords

ALCIAN BLUE; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; MUCIN; OZONE; PERIODIC ACID; SCHIFF BASE; SIVELESTAT;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SECRETION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; GOBLET CELL; GUINEA PIG; HISTOLOGY; LUNG LAVAGE; MORPHOMETRICS; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; TECHNIQUE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; ENZYME INHIBITORS; GLYCINE; GLYCOPROTEINS; GUINEA PIGS; LEUKOCYTE ELASTASE; MACROPHAGES, ALVEOLAR; MUCUS; OXIDANTS, PHOTOCHEMICAL; OZONE; RESPIRATORY MUCOSA; SULFONAMIDES; TRACHEA;

EID: 0034712021     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00921-8     Document Type: Article

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