Safety of selamectin in dogs

Veterinary Parasitology

Volumn 91, Issue 3-4, 2000, Pages 377-391

  Novotny, M J ^a   Krautmann, M J ^a   Ehrhart, J C ^b   Godin, C S ^b   Evans, E I ^c   McCall, J W ^d   Sun, F ^a   Rowan, T G ^e   Jernigan, A D ^a  

^a PFIZER INC   (United States)

^b White Eagle Toxicol Labs Inc   (United States)

^c MIDWEST RESEARCH INSTITUTE   (United States)

^d TRS Labs Inc   (United States)

^e PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Clinical safety; Dogs; Selamectin

Indexed keywords

AVERMECTIN; SELAMECTIN; UNCLASSIFIED DRUG;

ARTICLE; BREEDING; CONTROLLED STUDY; DIROFILARIA IMMITIS; DOG; DRUG SAFETY; FEMALE; INFESTATION; MALE; NONHUMAN; PARASITE CONTROL; REPRODUCTION;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; ANTHELMINTICS; ANTIPARASITIC AGENTS; DIROFILARIASIS; DOG DISEASES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ECTOPARASITIC INFESTATIONS; FEMALE; FETUS; IVERMECTIN; MALE; PREGNANCY; REPRODUCTION;

EID: 0034705867     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4017(00)00306-X     Document Type: Article

References (24)

1. Blagburn, B.L., Hendrix, C.M., Lindsay, D.S., Vaughan, J.L., Hepler, D.I., 1992. Post-adulticide milbemycin oxime microfilaricidal activity in dogs naturally infected with Dirofilaria immitis. In: Soll, M.D. (Ed.), Proceedings of the Heartworm Symposium'92. American Heartworm Society, Batavia, IL, pp. 159-164.
2. Drexler G., Sieghart W. Properties of high affinity binding site for tritium-labeled avermectin B1a. Eur. J. Pharmacol. 99:1984;269-277.
3. Drexler G., Sieghart W. Evidence for association of a high affinity avermectin binding site with benzodiazepine receptor. Eur. J. Pharmacol. 101:1984;201-207.
4. Drexler G., Sieghart W. Sulfur-35-labeled tert-butyl-bicyclophosphorothionate and avermectin bind to different sites associated with the gamma-aminobutyric acid-benzodiazepine receptor complex. Neurosci. Lett. 50:1984;273-277.
5. Duce I.R., Scott R.H. GABA sensitivity in the distal bundles of the locust extensor tibiae muscle. J. Physiol. 343:1983;32.
6. Duce I.R., Scott R.H. Actions of dihydroavermectin B1a on insect muscle. Brit. J. Pharmacol. 85:1985;395-401.
7. Jackson, R.F., Otto, G.F., 1975. Detection and differentiation of microfilariae. In: Morgan, H.E., Otto, G.F. (Eds.), Proceedings of the Heartworm Symposium'74. VM Publishing, Inc., Bonner Springs, KS, pp. 21-22.
8. Jacque C.M. La proteine gliofibrillaire acide [the glial fibrillary acidic protein]. Presse Med. (France). 20:1991;1384-1390.
9. Johnston S.D. Performing a complete canine semen evaluation in a small animal hospital. Vet. Clin. N. Am.: Small Anim. Pract. 21:1991;545-551.
10. Lankas G.R., Minsker D.H., Robertson R.T. Effects of ivermectin on reproduction and neonatal toxicity in rats. Food Chem. Toxicol. 27:1989;523-529.
11. Paul A.J., Tranquilli W.J., Seward R.L., Todd K.S., DiPietro J.A. Clinical observations in Collies given ivermectin orally. Am. J. Vet. Res. 48:1987;684-685.
12. Pulliam J.D., Seward R.L., Henry R.T., Steinberg S.A. Investigating ivermectin toxicity in Collies. Vet. Med. 80:1985;33-40.
13. Rawlings C.A., McCall J.W. Surgical transplantation of adult Dirofilaria immitis to study heartworm infection and disease in dogs. Am. J. Vet. Res. 46:1985;221-224.
14. Rose J.M., Peckham S.L., Scism J.L., Audus K.L. Evaluation of the role of P-glycoprotein in ivermectin uptake by primary cultures of bovine brain microvessel endothelial cells. Neurochem. Res. 23:1998;203-209.
15. Schaeffer J.M., Haines H.W. Avermectin binding in Caenorhabditis elegans: a two-state model for the avermectin binding site. Biochem. Pharmacol. 38:1989;2339-2349.
16. Schiffer D., Giordana M.T., Cavalla P., Vigliani M.C., Attanasio A. Immunohistochemistry of glial reaction after injury in the rat: double stainings and markers of cell proliferation. Int. J. Dev. Neurosci. 11:1993;269-280.
17. Schinkel A.H., Smitt J.J., van Tellingen O., Benijnen J.H. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 77:1994;491-502.
18. Schinkel A.H., Wagenaar E., Mol C.A., van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 9:1996;2517-2524.
19. Smith F.O. Postpartum diseases. Vet. Clin. N. Am.: Small Anim. Pract. 16:1986;521-524.
20. Snedecor, G.W., Cochran, W.G., 1989. Failures of assumptions. In: Statistical Methods, 8th Edition. Iowa State Univeristy Press, Ames, IA, pp. 274-297.
21. Soderberg S.F. Canine breeding management. Vet. Clin. N. Am.: Small Anim. Pract. 16:1986;419-433.
22. Tranquilli W.J., Paul A.J., Todd K.S. Assessment of toxicosis induced by high-dose administration of milbemycin oxime in collies. Am. J. Vet. Res. 52:1991;1170-1172.
23. Vassilatis D.K., Arena J.P., Plasterk R.H., Wilkinso H.A., Schaeffer J.M., Cully D.F., Van der Ploeg L.H. Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. J. Biol. Chem. 272:1997;33167-33174.
24. Wallace, M.S., Davidson, A.P., 1995. Abnormalities in pregnancy, parturition, and the periparturient period. In: Ettinger, S.J., Feldman, E.C. (Eds.), Textbook of Veterinary Internal Medicine, 4th Edition. W.B. Saunders Co., Philadelphia, PA, pp. 1614-1624.