Bile duct ligation promotes covalent drug-protein adduct formation in plasma but not in liver of rats given zomepirac

Life Sciences

Volumn 68, Issue 5, 2000, Pages 525-537

  Wang, Min ^a   Dickinson, Ronald G ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Acyl glucuronides; Cholestasis; Covalent adducts; Zomepirac

Indexed keywords

DRUG METABOLITE; NONSTEROID ANTIINFLAMMATORY AGENT; SERUM ALBUMIN; ZOMEPIRAC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILIARY EXCRETION; CHOLESTASIS; CONTROLLED STUDY; COVALENT BOND; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG LIVER LEVEL; DRUG PROTEIN BINDING; NONHUMAN; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BILE DUCTS; BLOOD PROTEINS; GALLBLADDER; GLUCURONIDES; ISOMERISM; LIVER; METABOLIC CLEARANCE RATE; PROTEIN BINDING; RATS; TOLMETIN;

ANIMALIA;

EID: 0034704317     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00958-9     Document Type: Article

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