Cortisol in critically ill patients with sepsis - Pathophysiology and therapeutic implications;Cortisol bei kritisch kranken patienten mit sepsis: Physiologische funktionen und therapeutische implikationen

Wiener Klinische Wochenschrift

Volumn 112, Issue 8, 2000, Pages 341-352

  Briegel, Josef ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Adrenal hormones; Cortisol; Glucocorticoid receptors; Host defense; Hydrocortisone; Immune response; Immunosuppression; Sepsis; Septic physiopathology; Shock; Therapy; Vasopressor

Indexed keywords

GLUCOCORTICOID RECEPTOR; HYDROCORTISONE;

ADRENAL CORTEX INSUFFICIENCY; CRITICAL ILLNESS; HEMODYNAMICS; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; INFECTION; PATHOPHYSIOLOGY; REVIEW; SEPSIS; SYSTEMIC VASCULAR RESISTANCE; VASODILATATION;

ADRENAL INSUFFICIENCY; ANTI-INFLAMMATORY AGENTS; ANTIBODY FORMATION; CRITICAL CARE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODYNAMIC PROCESSES; HUMANS; HYDROCORTISONE; RECEPTORS, GLUCOCORTICOID; SHOCK, SEPTIC; VASOMOTOR SYSTEM;

EID: 0034697191     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (111)

1. Weitzman S, Berger S (1974) Clinical trial design in studies of corticosteroids for bacterial infections. Ann Intern Med 81: 36-42
2. Hall WH, Gold D (1955) Shock associated with bacteremia. Arch Intern Med 96: 403-412
3. Bennett IL, Jr., Finland M, Hamburger M, Kass EH, Lepper M, Waisbren BA (1963) The effectiveness of hydrocortisone in the management of severe infections. JAMA 183: 462-465
4. Weil MH, Shubin H, Biddle M (1964) Shock caused by gram-negative Microorganisms. Analysis of 169 cases. Ann Intern Med 60: 384-400
5. Motsay GJ, Dietzman RH, Ersek RA, Lillehei RC (1970) Hemodynamic alterations and results of treatment in patients with gram-negative septic shock. Surgery 67: 577-583
6. Klastersky J, Cappel R, Debusscher L (1971) Effectiveness of betamethasone in management of severe infections. A double-blind study. N Engl J Med 284: 1248-1250
7. Schumer W (1976) Steroids in the treatment of clinical septic shock. Ann Surg 184: 333-341
8. Thompson WL, Gurley HT, Lutz BA, Jackson DL, Kvols LK, Morris IA (1976) Inefficacy of glucocorticoids in shock (double-blind study). Clin Res 24: 258A (Abstract)
9. Lucas CE, Ledgerwood AM (1984) The cardiopulmonary response to massive doses of steroids in patients with septic shock. Arch Surg 119: 537-541
10. Sprung CL, Caralis PV, Marcial EH, Pierge M, Gelbard MA, Long WM, Duncan RC, Tendler MD, Karpf M (1984) The effects of high-dose corticosteroids in patients with septic shock. N Engl J Med 311: 1137-1143
11. The Veterans Administration Systemic Sepsis Cooperative Study Group (1987) Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 317: 659-665
12. Bone RC, Fisher CJ jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA, The Methylprednisolone Severe Sepsis Study Group (1987) A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 317: 653-658
13. Luce JM, Montgomery AB, Marks JD, Turner J, Metz CA, Murray JF (1988) Ineffectiveness of high-dose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock. Am Rev Respir Dis 138: 62-68
14. Lefering R, Neugebauer EAM (1995) Steroid controversy in sepsis and septic shock: A meta-analysis. Crit Care Med 23: 1294-1303
15. Cronin L, Cook DJ, Carlet J, Heyland DK, King D, Lansang MAD, Fisher CJ jr (1995) Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med 23: 1430-1439
16. Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A (1998) Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 26: 645-650
17. Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, Stoll C, Peter K (1999) Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 27: 723-732
18. Selye H (1946) The general adaptation syndrome and the disease of adaptation. J Clin Endocrinol Metab 6: 117-230
19. Munck A, Guyre PM, Holbrook NJ (1984) Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 5: 25-44
20. Ledingham IM, Watt I (1983) Influence of sedation on mortality in critically ill multiple trauma patients. Lancet i: 1270
21. Wagner RL, White PF, Kan PB, Rosenthal MH, Feldman D (1984) Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 310: 1415-1421
22. Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332: 1351-1362
23. Zuckerman SH, Shellhaas J, Butler LD (1989) Differential regulation of lipopolysaccharide-induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary-adrenal axis. Eur J Imnunol 19: 301-305
24. Kass EH, Finland M (1958) Corticosteroids and Infections. Adv Intern Med 9: 45-80
25. Udelsman R, Ramp J, Gallucci WT, Gordon A, Lipford E, Norton JA, Loriaux DL, Chrousos GP (1986) Adaptation during surgical stress. A reevaluation of the role of glucocorticoids. J Clin Invest 77: 1377-1381
26. Thomas JP, El-Shaboury AH (1971) Aldosterone secretion in steroid-treated patients with adrenal suppression. Lancet i: 623-625
27. Guyre PM, Munck A (1989) Glucocorticoid actions on monocytes and macrophages. In: Schleimer RP, Claman HN, Oronsky A (eds) Ant-inflammatory steroid action: basic and clinical aspects. Academic Press. Inc., San Diego, pp 199-225
28. Rees AJ, Lockwood CM (1993) Immunosuppressive drugs in clinical practice. In: Lachmann PJ, Peters K, Rosen FS, Walport MJ (eds) Clinical aspects of immunology. Blackwell Scientific Publications, Boston Oxford London Edinburgh, pp 929-969
29. Waage A, Bakke O (1988) Glucocorticoids suppress the production of tumor necrosis factor by lipopolysaccharide-stimulated human monocytes. Immunology 63: 299-302
30. Barber AE, Coyle SM, Fong Y, Fischer E, Marano MA, Calvano SE, Moldawer LL, Shires T, Lowry SF (1990) Impact of hypercortisolemia on the metabolic and hormonal responses to endotoxin in humans. Surg Forum 41: 74-77
31. Santos AA, Scheltinga MR, Lynch E, Brown EF, Lawton P, Chambers E, Browning J, Dinarello CA, Wolff SM, Wilmore DW (1993) Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Arch Surg 128: 138-144
32. Barber AE, Coyle SM, Marano MA, Fischer E, Calvano SE, Fong Y, Moldawer LL, Lowry SF (1993) Glucocorticoid therapy alters hormonal and cytokine response to endotoxin in man. J Immunol 150: 1999-2006
33. Barber AE, Coyle SM, Fischer E, Smith C, Van der Poll T, Shires GT, Lowry SF (1995) Influence of hypercortisolemia on soluble tumor necrosis factor receptor II and interleukin-1 receptor antagonist responses to endotoxin in human beings. Surgery 118: 406-411
34. Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G (1992) A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci US A 89: 9991-9995
35. Briegel J, Kellermann W, Forst H, Haller M, Bittl M, Hoffmann GE, Büchler M, Uhl W, Peter K, Phospholipase A2 Study Group (1994) Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome. Clin Investig 72: 782-787
36. Ingle DJ (1954) Permissibility of hormone action. A review. Acta Endocrinol (Copenh.) 17: 172-186
37. Chikanza IC, Panayi GS (1993) The effects of hydrocortisone on in vitro lymphocyte proliferation and interleukin-2 and -4 production in corticosteroid sensitive and resistant subjects. Eur J Clin Invest 23: 845-850
38. Van der Poll T, Barber AE, Coyle SM, Lowry SF (1996) Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia - A clinical research center study. J Clin Endocrinol Metab 81: 3604-3606
39. Arzt E, Sauer J, Pollmächer T, Labeur M, Holsboer F, Reul JMHM, Stalla GK (1994) Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin. Endocrinology 134: 672-677
40. Wiegers GJ, Reul JM (1998) Induction of cytokine receptors by glucocorticoids: functional and pathological significance. Trends Pharmacol Sci 19: 317-321
41. Munck A, Náray-Fejes-Tóth A (1994) Glucocorticoids and stress: Permissive and suppressive actions. Ann NY Acad Sci 746: 115-120
42. Strickland RW, Wahl LM, Finbloom DS (1986) Corticosteroids enhance the binding of recombinant interferon-gamma to cultured human monocytes. J Immunol 137: 1577-1580
43. Snyers L, De Wit L, Content J (1990) Glucocorticoid upregulation of high-affinity interleukin 6 receptors on human epithelial cells. Proc Natl Acad Sci USA 87: 2838-2842
44. Bertoglio JH, Leroux E (1988) Differential effects of glucocorticoids on the proliferation of a murine helper and a cytolytic T cell clone in response to IL-2 and IL-4. J Immunol 141: 1191-1196
45. Klebl FH, Weber G, Kalden JR, Nüsslein HG (1994) In vitro and in vivo effect of glucocorticoids on IgE and IgG subclass secretion. Clin Exp Allergy 24: 1022-1029
46. Kimata H, Lindley I, Furusho K (1995) Effect of hydrocortisone on spontaneous IgE and IgG4 production in atopic patients. J Immunol 154: 3557-3566
47. Reincke M, Allolio B, Wurth G, Winkelmann W (1993) The hypothalamic-pituitary-adrenal axis in critical illness: response to dexamethasone and corticotropin-releasing hormone. J Clin Endocrinol Metab 77: 151-156
48. Parker LN, Levin ER, Lifrak ET (1985) Evidence for adrenocortical adaptation to severe illness. J Clin Endocrinol Metab 60: 947-952
49. Jurney TH, Cockrell JL, Lindberg JS, Lamiell JM, Wade CE (1987) Spectrum of serum cortisol response to ACTH in ICU patients. Chest 92: 292-295
50. Span LFR, Hermus ARMM, Bartelink AKM, Hoitsma AJ, Gimbrère JSF, Smals AGH, Kloppenborg PWC (1992) Adrenocortical function: an indicator of severity of disease and survival in chronic critically ill patients. Intensive Care Med 18: 93-96
51. Wade CE, Lindberg JS, Cockrell JL, Lamiell JM, Hunt MM, Ducey J, Jurney TH (1988) Upon-admission adrenal steroidogenesis is adapted to the degree of illness in intensive care unit patients. J Clin Endocrinol Metab 67: 223-227
52. Zipser RD, Davenport MW, Martin KL, Tuck ML, Warner NE, Swinney RR, Davis CL, Horton R (1981) Hyperreninemic hypoaldosteronism in the critically ill: a new entity. J Clin Endocrinol Metab 53: 867-873
53. Findling JW, Waters VO, Hershel R (1987) The dissociation of renin and aldosterone during critical illness. J Clin Endocrinol Metab 64: 592-595
54. Woolf PD, Hamill RW, McDonald JV, Lee LA, Kelly M (1985) Transient hypogonadotropic hypogonadism caused by critical illness. J Clin Endocrinol Metab 60: 444-450
55. Melby JC, Egdahl RH, Spink WW (1960) Secretion and metabolism of cortisol after injection of endotoxin. J Lab Clin Med 56: 50-62
56. Perrot D, Bonneton A, Dechaud H, Motin J, Pugeat M (1993) Hypercortisolism in septic shock is not suppressible by dexamethasone infusion. Crit Care Med 21: 396-401
57. Vogeser M, Felbinger TW, Kilger E, Roll W, Fraunberger P, Jacob K (1999) Corticosteroid-binding globulin and free cortisol in the early postoperative period after cardiac surgery. Clin Biochem 32: 213-216
58. Harris MJ, Baker RT, McRoberts JW, Mohler JL (1990) The adrenal response to trauma, operation and cosyntropin stimulation. Surg Gynecol Obstet 170: 513-516
59. Udelsman R, Norton JA, Jelenich SE, Goldstein DS, Linehan WM, Loriaux DL, Chrousos GP (1987) Responses of the hypothalamic-pituitary-adrenal and reninangiotensin axes and the sympathetic system during controlled surgical and anesthetic stress. J Clin Endocrinol Metab 64: 986-994
60. Veldhuis JD, Iranmanesh A, Lizarralde G, Johnson ML (1989) Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm. Am J Physiol 257: E6-14
61. Van den Berg G, Frölich M, Veldhuis JD, Roelfsema F (1995) Combined amplification of the pulsatile and basal modes of adrenocorticotropin and cortisol secretion in patients with Cushing's disease: Evidence for decreased responsiveness of the adrenal glands. J Clin Endocrinol Metab 80: 3750-3757
62. Salem M, Tainsh RE, Bromberg J, Loriaux DL, Chernow B (1994) Perioperative glucocorticoid coverage. Ann Surg 219: 416-425
63. Lamberts SW, Bruining HA, de JF (1997) Corticosteroid therapy in severe illness. N Engl J Med 337: 1285-1292
64. Peterson RE, Nokes G, Chen PS, Black RL (1960) Estrogens and adrenocortical function in man. J Clin Endocrinol Metab 20: 495-514
65. Kehlet H, Binder C (1973) Value of an ACTH test in assessing hypothalamic-pituitary-adrenocortical function in glucocorticoid-treated patients. BMJ 2: 147-149
66. Bassoe HH, Aarskog D, Thorsen T, Stoa KF (1965) Cortisol production rate in patients with acute bacterial infections. Acta Med Scand 177: 701-705
67. Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G (1990) Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the cortictropic axis in man. J Clin Endocrinol Metab 71: 452-463
68. Voerman HJ, Strack van Schijndel RJM, Groeneveld ABJ, De Boer H, Nauta JP, Thijs LG (1992) Pulsatile hormone secretion during severe sepsis: accuracy of different blood sampling regimens. Metabolism 41: 934-940
69. Tayek JA, Atienza VJ (1995) Pituitary-adrenal axis function in systemic inflammatory response syndrome. Endocrine 3: 315-318
70. Molijn GJ, Spek JJ, Van Uffelen JCJ, De Jong FH, Brinkmann AO, Bruining HA, Lamberts SWJ, Koper JW (1995) Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock. J Clin Endocrinol Metab 80: 1799-1803
71. Gaillard RC, Turnill D, Sappino P, Muller AF (1990) Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 127: 101-106
72. Jäättelä M, Ilvesmäki V, Voutilainen R, Stenman U-H, Saksela E (1991) Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells. Endocrinology 128: 623-629
73. Feige J-J, Cochet C, Rainey WE, Madani C, Chambaz EM (1987) Type β transforming growth factor affects adrenocortical cell-differentiated functions. J Biol Chem 262: 13491-13495
74. Hotta M, Baird A (1986) Differential effects of transforming growth factor type β on the growth and function of adrenocortical cells in vitro. Proc Natl Acad Sci USA 83: 7795-7799
75. Singh A, Bateman A, Zhu Q, Shimasaki S, Esch F, Solomon S (1988) Structure of a novel human granulocyte peptide with anti-acth activity. Biochem Biophys Res Commun 155: 524-529
76. Vermes I, Beishuizen A, Hampsink RM, Haanen C (1995) Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: Possible role of endothelin and atrial natriuretic hormone. J Clin Endocrinol Metab 80: 1238-1242
77. Roth-Isigkeit AK, Schmucker P (1997) Postoperative dissociation of blood levels of cortisol and adrenocorticotropin after coronary artery bypass grafting surgery. Steroids 62: 695-699
78. Schein RMH, Sprung CL, Marcial E, Napolitano L, Chernow B (1990) Plasma cortisol levels in patients with septic shock. Crit Care Med 18: 259-263
79. Bouachour G, Tirol P, Gouello JP, Mathieu E, Vincent JF, Alquier P (1995) Adrenocortical function during septic shock. Intensive Care Med 21: 57-62
80. Rothwell PM, Udwadia ZF, Lawler PG (1991) Cortisol response to corticotropin and survival in septic shock Cortisol response to corticotropin and survival in septic shock. Lancet 337: 582-583
81. Briegel J, Schelling G, Haller M, Mraz W, Forst H, Peter K (1996) A comparison of the adrenocortical response during septic shock and after complete recovery. Intensive Care Med 22: 894-899
82. Drucker D, Shandling M (1985) Variable adrenocortical function in acute medical illness. Crit Care Med 13: 477-479
83. Zonghai H, Han G, Renbao X (1987) Study on glucocorticoid receptors during intestinal ischemia shock and septic shock. Circ Res 23: 27-36
84. Molijn GJ, Koper JW, Van Uffelen CJC, De Jong FH, Brinkmann AO, Bruining HA, Lamberts SWJ (1995) Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock. Clin Endocrinol (Oxf.) 43: 197-203
85. Barnes PJ (1995) Anti-inflammatory mechanisms of glucocorticoids. Biochem Soc Trans 23: 940-945
86. Sambhi MP, Weil MH, Udhoji VN (1962) Pressor responses to norepinephrine in humans before and after corticosteroids. Am J Physiol 203/5: 961-963
87. Besse JC, Bass AD (1966) Potentiation by hydrocortisone of responses to catecholamines in vascular smooth muscle. J Pharmacol Exp Therap 154: 224-238
88. Kadowitz PJ, Yard AC (1970) Circulatory effects of hydrocortisone and protection against endotoxin shock in cats. Eur J Pharmacol 9: 311-318
89. Kalsner S (1969) Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta. Circ Res 24: 383-395
90. Annane D, Messika D, Raphaël JC, Gajdos P (1994) Correlation between low cortisol response to corticotropin and vessels hypocontractility in human septic shock. Am J Respir Crit Care Med 149: A648 (Abstract)
91. Altura BM, Altura BT (1974) Peripheral vascular actions of glucocorticoids and their relationship to protection in circulatory shock. J Pharmacol Exp Therap 190: 300-315
92. Bernard C, Tedgui A (1992) Cytokine network and the vessel wall. Insights into septic shock pathogenesis. Eur Cytokine Netw 3: 19-33
93. Suba EA, McKenna TM, Williams TJ (1992) In vivo and in vitro effects of endotoxin on vascular responsiveness to norepinephrine and signal transduction in the rat. Circ Shock 36: 127-133
94. Clore J, Schoolwerth A, Watlington CO (1992) When is cortisol a mineralocorticoid. Kidney Int 42: 1297-1308
95. Kornel L, Nelson WA, Manisundarum B, Chigurupati R, Hayashi T (1993) Mechanism of the effects of glucocorticoids and mineralocorticoids on vascular smooth muscle contractility. Steroids 58: 580-587
96. Moura AM, Worcel M (1984) Direct action of aldosterone on transmembrane 22Na efflux from arterial smooth muscle. Rapid and delayed effects. Hypertension 6: 425-430
97. Walker BR, Best R, Shackleton CHL, Padfield PL, Edwards CRW (1996) Increased vasoconstrictor sensitivity to glucocorticoids in essential hypertension. Hypertension 27: 190-196
98. Whitworth JA, Brown MA, Kelly JJ, Williamson PM (1995) Mechanisms of cortisol-induced hypertension in humans. Steroids 60: 76-80
99. Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012
100. Palmer RMJ (1993) The discovery of nitric oxide in the vessel wall: A unifying concept in the pathogenesis of sepsis. Arch Surg 128: 396-401
101. Nussler AK, Billiar TR, Simmons RL (1995) Inducible nitric oxide synthase: Its role in inflammation, sepsis, and shock. Prog Surg 20: 33-50
102. Schott CA, Gray GA, Stoclet J-C (1993) Dependence of endotoxin-induced vascular hyporeactivity on extracellular L-arginine. Br J Pharmacol 108: 38-43
103. Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P (1994) Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 28: 34-39
104. Radomski MW, Palmer RMJ, Moncada S (1990) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87: 10043-10047
105. Warren JB, Loi RK, Coughlan ML (1993) Involvement of nitric oxide synthase in the delayed vasodilator response to ultraviolet light irradiation of rat skin in vivo. Br J Pharmacol 109: 802-806
106. Keh D, Weber-Carstens S, Böhnke T, Schulz C, Petterson M, Ahlers O, Bercker S, Berg A, Risse G, Nordman M, Falke K, Gerlach H (1999) Effects of hydrocortisone stress-dose therapy in septic shock (part I): influence on hemodynamic stability and plasma nitrite/nitrate levels. Critical Care 3: P104 (Abstract)
107. Lin PJ, Chang C-H, Chang J-P (1994) Reversal of refractory hypotension in septic shock by inhibitor of nitric oxide synthase. Chest 106: 626-629
108. Lin L-L, Lin AY, Knopf JL (1992) Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci USA 89: 6147-6151
109. Dinarello CA, Wolff SM (1990) Pathogenesis of fever. In: Mandell GL, Douglas RG, Bennett JE (eds) Infectious diseases. Churchill Livingstone, New York Edinburgh London Melbourne, pp 462-467
110. Billiau A, Vandekerckhove F (1991) Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock. Eur J Clin Invest 21: 559-573
111. Bhagat K, Collier J, Vallance P (1996) Local venous responses to endotoxin in humans. Circulation 94: 490-497