Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 4, 2000, Pages 319-322

  Martín, Elena ^a   Morán, Asunción ^a   Martín, Ma Luisa ^a   San Román, Luis ^a   Puebla, Pilar ^a   Medarde, Manuel ^a   Caballero, Esther ^a   San Feliciano, Arturo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

7 (3 NITROPHENYL) 5,8A DIMETHYL 6 METHOXYCARBONYL 2,3,8,8A TETRAHYDRO 7H OXAZOLO[3,2 A]PYRIDINE 8 CARBOXYLYC ACID ETHYL ESTER; CARBOXYLIC ACID DERIVATIVE; NIFEDIPINE; OXAZOLOPYRIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MALE; NONHUMAN; RACEMIC MIXTURE; RAT; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DRUG EVALUATION; HEART RATE; MALE; NIFEDIPINE; OXAZOLES; PYRIDINES; RATS; RATS, INBRED SHR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

ANIMALIA;

EID: 0034696065     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00691-5     Document Type: Article

References (25)

1. San Feliciano A., Caballero E., Pereira J.A.P., Puebla P. Tetrahedron. 47:1991;6503.
2. Caballero E., Puebla P., Medarde M., San Feliciano A. Tetrahedron. 49:1993;10079.
3. Caballero E., Puebla P., Medarde M., Honores Z., Sastre P., López J.L., San Feliciano A. Tetrahedron Lett. 39:1998;455.
4. San Feliciano A., Caballero E., Puebla P., Pereira J.A.P., Gras J., Valenti C. Eur. J. Med. Chem. 27:1992;527.
5. Morán A., Martín E., Velasco C., Martín M.L., San Román L., Caballero E., Puebla P., Medarde M., San Feliciano A. J. Pharm. Pharmacol. 49:1997;421.
6. Bayer R., Kalusche D., Kaufmann R., Mannhold R. Naunyn-Schmiedeb. Arch. Pharmacol. 290:1975;81.
7. Sato M., Nagao T., Yamaguchi I., Nakajima H., Kiyomoto A. Arzneim. Forsch. Drug Res. 21:1971;1338.
8. Towart R., Wehinger E., Meyer H. Naunyn-Schmiedeb. Arch. Pharmacol. 317:1981;183.
9. Okumura K., Ichihara K., Nagasaka M., Oda N., Tajima K. Eur. J. Pharmacol. 235:1993;69.
10. Mikus G., Mast V., Ratge D., Wisser H., Eichelbaum M. Clin. Pharmacol. Ther. 57:1995;52.
11. Tamazawa K., Arima H., Kojima T., Isomura Y., Okada M., Fujita S., Furuya T., Takenaka T., Inagaki O., Terai M. J. Med. Chem. 29:1986;2504.
12. Goldmann S., Stoltefuss J. Angew. Chem., Int. Ed. Engl. 30:1991;1559.
13. Goldmann S., Stoltefuss J., Born L. J. Med. Chem. 35:1992;3341.
14. Ashimori A., Uchida T., Ohtaki Y., Tanaka M., Ohe K., Fukaya C., Watanabe M., Kagitani M., Yokoyama K. Chem. Pharm. Bull. 39:1991;108.
15. Enders D., Müller S., Demir A.S. Tetrahedron Lett. 29:1988;6437.
16. Ebiike H., Maruyama K., Achiwa K. Tetrahedron: Asymmetry. 3:1992;1153.
17. Ikeda K., Kato T., Suzuki T., Achiwa K. Chem. Pharm. Bull. 46:1998;518.
18. Puebla, P., Gotor, V., unpublished results.
19. Caballero E., Puebla P., Medarde M., Sánchez M., Salvadó M.A., García-Grande S., San Feliciano A. J. Org. Chem. 61:1996;1890.
20. Caballero E., Puebla P., Sánchez M., Medarde M., Morán L., San Feliciano A. Tetrahedron: Asymmetry. 7:1996;1985.
21. 3).
22. Smith D.F. Pharmacol. Toxicol. 65:1989;321.
23. Eltze M., Boer R., Sanders K.H., Boss H., Ulrich W.R., Flockerzi D. Chirality. 2:1990;233.
24. Hof R.P., Rüegg U.T., Hof A., Vogel A. J. Cardiovasc. Pharmacol. 7:1985;689.
25. Niva T., Tokuma Y., Nakagawa K., Nogushi H., Yamazoe Y., Kato R. Res. Commum Chem. Pathol. Pharmacol. 60:1988;161.