Concurrent detection of gene mutations and chromosome aberrations induced by five chemicals in a CHL/IU cell line incorporating a gpt shuttle vector

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 471, Issue 1-2, 2000, Pages 29-36

  Yamada, Toru ^a   Odawara, Kyoko ^a   Kaneko, Hideo ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

ENU; Genetically engineered CHL IU cells; gpt; MMC; MMS; Shuttle vector

Indexed keywords

CHLORIDE; ETHYLNITROSOUREA; MESYLIC ACID METHYL ESTER; MITOMYCIN C; NITROSOGUANIDINE; TIOGUANINE; VINCRISTINE SULFATE;

ANIMAL CELL; ARTICLE; CELL LINE; CHEMICAL MUTAGENESIS; CHO CELL; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; ESCHERICHIA COLI; GENE MUTATION; GENETIC ANALYSIS; GENOME; METAPHASE; NONHUMAN; PRIORITY JOURNAL; SHUTTLE VECTOR;

ANIMALS; BACTERIAL PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ETHYLNITROSOUREA; GENETIC VECTORS; METHYL METHANESULFONATE; MITOMYCIN; MUTAGENESIS; MUTAGENS; PENTOSYLTRANSFERASES; PROTEINS; ROSANILINE DYES; TOLUIDINES; VINCRISTINE;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA COLI;

EID: 0034694176     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00115-7     Document Type: Article

References (42)

1. Mechanism of activation and inactivation of dominant oncogenes and tumor suppressor genes
2. Cellular oncogenes and multistep carcinogenesis
3. Mutagenic activity of some clastogenic chemicals at the hypoxanthine guanine phosphoribosyl transferase locus of Chinese hamster ovary cells
4. Comparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: Strategies for predictive use of short-term assays
5. Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier of results with 41 additional chemicals
6. An evaluation of 6 chromosome mutagens in the AS52/XPRT mutation assay utilizing suspension culture and soft agar cloning
7. Development of a novel CHL/IU cell line with an incorporated gpt shuttle vector for concurrent analysis of gene mutations and chromosome aberrations
8. Chromosome test with 134 compounds on Chinese hamster cells in vitro: A screening for chemical carcinogens
9. A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) systems in culture
10. Nucleotide sequence of the xanthine guanine phosphoribosyl transferase gene of E. coli
11. Cosmids: A type of plasmid gene-cloning vector that is packageable in vitro in bacteriophage heads
12. 6: 7-Alkylguanine ratio in DNA with carcinogenic potency in rodents
13. A review of the genotoxicity of 1-ethyl-1-nitrosourea
14. DNA modification and cancer
15. Kinetochore identification in micronuclei in mouse bone-marrow erythrocytes: An assay for the detection of aneuploidy-inducing agents
16. Toxicity and mutagenicity of 6 anti-cancer drugs in Chinese hamster V79 cells co-cultured with rat hepatocytes
17. Relative mutagenicity of antineoplastic drugs and other alkylating agents in V79 Chinese hamster cells, independence of cytotoxic and mutagenic responses
18. Ten model mutagens evaluated by the micronucleus test
19. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Methods used and chemicals evaluated
20. Chromosome aberration and sister chromatid exchange test results with 42 chemicals
21. Isolation of high-molecular-weight DNA from mammalian cells
22. Tables for determining the statistical significance of mutation frequencies
23. Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells: A correlation with different ethylation products in DNA
24. Comparison of 6-thioguanine-resistant mutation and sister chromatid exchanges in Chinese hamster V79 cells with forty chemical and physical agents
25. An evaluation of the CHO/HGPRT mutation assay involving suspension cultures and soft agar cloning: Results for 33 chemicals
26. Oncogenesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents
27. Molecular analysis of mutation at the hprt locus of Chinese hamster V79 cells induced by ethyl methanesulphonate and mitomycin C
28. Methylmethane-sulphonate and X-ray-induced mutations in the Chinese hamster hprt gene: mRNA phenotyping using polymerase chain reactions
29. Locus specificity in the mutability of L5178Y mouse lymphoma cells: The role of multilocus lesions
30. Cloning in cosmid vectors
31. Mutagenicity and cytotoxicity of congeners of two classes of nitroso compounds in Chinese hamster ovary cells
32. Isolation of a menadione-resistant subclone from Chinese hamster lung (CHL) cells in culture
33. Ethylnitrosourea-induced mutation and molecular analysis of transgenic mice containing the gpt shuttle vector
34. Quantitative relationship between ethylated DNA bases and gene mutation at two loci in CHO cells
35. Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents
36. Potent mutagenic activity of nitro pyrene on Chinese hamster lung cells with diphtheria toxin resistance as a marker
37. Mutagenic activities of heterocyclic amines in Chinese hamster lung cells in culture
38. Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a marker
39. Stable expression of monkey cytochrome P-450IA1 cDNA in Chinese hamster CHL cells and its application for detection of mutagenicity of aflatoxin B1
40. Analysis of cytogenetic effects and DNA adduct formation induced by safrole in Chinese hamster lung cells