Homocysteine and methylmalonic acid markers for cobalamin/folate status Their association with neuropsychiatric symptoms in the elderly is explored;Homocystein och metylmalonsyra markörer för kobalamin-/folatstatus: Relationen till neuropsykiatriska symtom hos äldre belyses

Lakartidningen

Volumn 97, Issue 38, 2000, Pages 4131-4136

  Hultberg, Björn ^a   Isaksson, Anders ^a   Nilsson, Karin ^a   Gustafson, Lars ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HOMOCYSTEINE; METHYLMALONIC ACID;

AGED; BLOOD; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; DIFFERENTIAL DIAGNOSIS; FOLIC ACID DEFICIENCY; GERONTOPSYCHIATRY; HUMAN; MENTAL DISEASE; PSYCHOLOGICAL ASPECT; REFERENCE VALUE; REVIEW;

AGED; BIOLOGICAL MARKERS; COGNITION DISORDERS; DIAGNOSIS, DIFFERENTIAL; FOLIC ACID DEFICIENCY; GERIATRIC PSYCHIATRY; HOMOCYSTEINE; HUMANS; MENTAL DISORDERS; METHYLMALONIC ACID; REFERENCE VALUES; VITAMIN B 12 DEFICIENCY;

EID: 0034692307     PISSN: 00237205     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Bottiglieri T. Folate, vitamin B-12 and neuropsychiatric disorders. Nutr Rev 1996; 54: 382-90.
2. Lindenbaum J, Healton EB, Savage DG, Brust JCM, Garrett TJ, Podsell ER et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988; 318: 1720-8.
3. Alpert JE, Fava M. Nutrition and depression. The role of folate. Nutr Rev 1997; 55: 145-9.
4. Nilsson K, Gustafson L, Hultberg B. Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamins and folates in a psychogeriatric population. Dement Geriatr Cogn Disord 1999; 10: 476-82.
5. Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency. A guide for the primary care physician. Arch Intern Med 1999; 159: 1289-98.
6. Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration. In: Scriver CG, Beaudet AL, Sly WS, Valle D, eds. The metabolic and molecular basis of inherited disease. 7th ed. New York: McGraw-Hill Book Co, 1995: 1279-327.
7. Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994; 96: 239-46.
8. Nexø E, Hansen M, Rasmussen K, Lindgren A, Gräsbeck R. How to diagnose cobalamin deficiency. Scand J Clin Lab Invest 1994; 54(Suppl 219): 61-76.
9. Bolander-Gouaille C. Focus on homocysteine. Paris: Springer Verlag, 2000.
10. Chanarin I, Metz J. Diagnosis of cobalamin deficiency: The old and the new. Br J Haematol 1997; 97: 695-700.
11. Stabler S, Lindenbaum J, Allen RH. Vitamin B-12 deficiency in the elderly: current dilemmas. Am J Clin Nutr 1997: 66: 741-9.
12. Nilsson K, Gustafson L, Fäldt R, Andersson A, Vaara I, Nilsson R et al. Plasma methylmalonic acid in relation to serum cobalamin and plasma homocysteine in a psychogeriatric population and the effect of cobalamin treatment. Int J Geriatr Psychiatry 1997; 12: 62-72.
13. Nilsson K, Gustafson L, Fäldt R, Andersson A, Hultberg B. Plasma homocysteine in relation to serum cobalamin and blood folate in a psychogeriatric population. Eur J Clin Invest 1994; 24: 600-6.
14. Nilsson K, Gustafson L, Fäldt R, Andersson A, Brattström L, Lindgren A et al. Hyperhomocysteinemia - a common finding in a psychogeriatric population. Eur J Clin Invest 1996; 26: 853-9.
15. Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine and neurocognitive function in the elderly. Am J Clin Nutr 2000; 71(suppl): 614S-20S.
16. Riggs KM, Spiro A, Tucker K, Rush D. Relations of vitamin B12, vitamin B6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 1996; 63: 306-14.
17. Jensen E, Dehlin O, Erfurth EM, Hagberg B, Samuelsson G, Svensson T et al. Plasma homocysteine in 80-year-olds. Relationship to medical physiological and social variables. Archives of Gerontology and Geriatrics 1998; 26: 215-26.
18. Hultberg B, Jensen E, Dehlin O, Hagberg B, Samuelsson G, Svensson T. Concentrations of plasma methylmalonic acid in 80-year-olds show only weak relation to psychological performance. Clin Chem Lab Med 1999; 37: 963-7.
19. Lehmann M, Gottfries CG, Regland B. Identification of cognitive impairment in the elderly: Homocysteine is an early marker. Dement Geriatr Cogn Disord 1999; 10: 12-20.
20. Nilsson K, Gustafson L, Hultberg B. The concentration of plasma homocysteine is better than that of serum methylmalonic acid as a marker for socio-psychological performance in a psychogeriatric population. Clin Chem. Under publ.