AMP deaminase inhibitors. 4. Further N3-substituted coformycin aglycon analogues: N3-alkylmalonates as ribose 5'-monophosphate mimetics

Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2000, Pages 1519-1524

  Bookser, Brett C ^a   Kasibhatla, Srinivas Rao ^a   Erion, Mark D ^a  

^a Metabasis Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5,5 DICARBOXY 6 (3 (TRIFLUOROMETHYL)PHENYL N HEXYL)COFORMYCIN AGLYCON; ADENOSINE PHOSPHATE DEAMINASE; ADENOSINE PHOSPHATE DEAMINASE INHIBITOR; COFORMYCIN; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BRAIN PROTECTION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEART PROTECTION;

AMP DEAMINASE; BINDING SITES; COFORMYCIN; ENZYME INHIBITORS; MALONATES; MOLECULAR MIMICRY; PHOSPHORIC ACID ESTERS; RIBOSE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034692164     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9905413     Document Type: Article

References (19)

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13. The triethyl and trimethyl esters have been prepared and the former is commercially available from TCI (cat. no. T1481) and Aldrich (cat. no. T6.020-8): (a) Lund, H.; Voigt, A. Tricarboethoxymethane. Organic Synthesis; Wiley: New York, 1946; Collect. Vol. II, pp 594-596.
14. The triethyl and trimethyl esters have been prepared and the former is commercially available from TCI (cat. no. T1481) and Aldrich (cat. no. T6.020-8): (a) Lund, H.; Voigt, A. Tricarboethoxymethane. Organic Synthesis; Wiley: New York, 1946; Collect. Vol. II, pp 594-596.
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19. Compound 19 is a close analogue to compounds already described. For the synthesis and SAR of this group of monocarboxylic acids, see ref 3.