H-2(d) mice born to and reared by HBeAg-transgenic mothers do not develop T cell tolerance toward the hepatitis B virus core gene products

Virology

Volumn 273, Issue 1, 2000, Pages 149-159

  Merkle, Heidrun ^a   Deutschle, Tom ^a   Gastrock Balitsch, Iris ^a   Nusser, Petra ^a   Knehr, Susanne ^a   Reifenberg, Kurt ^b  

^a UNIVERSITY OF ULM   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; HEPATITIS B(E) ANTIGEN;

ARTICLE; BREAST MILK; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; IMMUNOLOGICAL TOLERANCE; MOUSE; NEWBORN; NONHUMAN; PLACENTAL TRANSFER; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE; URINARY EXCRETION; VERTICAL TRANSMISSION;

ANIMALIA; DNA VIRUSES; HEPATITIS B VIRUS; MURINAE; MUS MUSCULUS;

EID: 0034691516     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0391     Document Type: Article

References (44)

1. Arakawa K., Tsuda F., Takahashi K., Ise I., Naito S., Kosugi E., Miyakawa Y., Mayumi M. Maternal-fetal transmission of IgG bound hepatitis B e antigen. Pediatr. Res. 16:1982;247-250.
2. Bennett S. R., Carbone F. R., Karamalis F., Flavell R. A., Miller J. F., Heath W. R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 393:1998;478-480.
3. Biswas S., Gupta I., Ganguly N., Chawla Y., Dilawari J. Prevalence of hepatitis B virus surface antigen in pregnant mothers and its perinatal transmission. Trans. R. Soc. Trop. Med. Hyg. 83:1989;698-700.
4. Brunetto M. R., Giarin M. M., Oliveri F., Chiaberge E., Baldi M., Alfarano A., Serra A., Saracco G., Verme G., Will H., Bonino F. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc. Natl. Acad. Sci. USA. 88:1991;4186-4190.
5. Chang C., Enders G., Sprengel R., Peters N., Varmus H., Ganem D. Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J. Virol. 61:1987;3322-3325.
6. Chen H., Kew M., Hornbuckle W., Tennant B., Cote P., Gerin J., Purcell R., Miller R. The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host. J. Virol. 66:1992;5682-5684.
7. Davis H., Demeneix B., Quantin B., Coulombe J., Whalen R. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum. Gene Ther. 4:1993a;733-740.
8. Davis H., Michel M., Whalen R. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Mol. Genet. 2:1993b;1847-1851.
9. Diepolder H. M., Ries G., Jung M. C., Schlicht H.-J., Gerlach J. T., Gruner N., Caselmann W. H., Pape G. R. Differential antigen-processing pathways of the hepatitis B virus e and core proteins. Gastroenterology. 116:1999;650-657.
10. Ganem D., Varmus H. The molecular biology of the hepatitis B viruses. Annu. Rev. Biochem. 56:1987;651-693.
11. Garcia P., Ou J., Rutter W., Walter P. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: After signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J. Cell Biol. 106:1988;1093-2004.
12. Guidotti L. G., Matzke B., Pasquinelli C., Schoenberger J. M., Rogler C. E., Chisari F. V. The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice. J. Virol. 70:1996;7056-7061.
13. Hsieh C. S., Heimberger A. B., Gold J. S., O'Garra A., Murphy K. M. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89:1992;6065-6069.
14. Junker M., Galle P., Schaller H. Expression and replication of the hepatitis B virus genome under foreign promoter control. Nucleic Acids Res. 15:1987;10117-10132.
15. b mice. J. Immunol. 156:1996;3687-3695.
16. d-restricted epitopes. Int. Immunol. 9:1997;1203-1212.
17. Lambert C., Nassal M., Velhagen I., Zentgraf H., Schroder C. H. Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis. J. Virol. 67:1993;3756-3762.
18. Lee S., Lo K., Tsai Y., Wu J. Maternal hepatitis B virus DNA in mother-infant transmission. Lancet. 1:1989;719.
19. Li L., Sheng M., Tong S., Chen H., Wen Y. Transplacental transmission of hepatitis B virus. Lancet. 2:1986;872.
20. Merkle H., Nusser P., Knehr S., Löhler J., Barsig J., Yamamura K.-I., Reifenberg K. Hepatocytes of double-transgenic mice expressing high levels of hepatitis B virus e antigen and IFNγ are not injured by HBeAg specific autoantibodies. Arch. Virol. 145:2000;1081-1098.
21. Milich D. R., McLachlan A., Thornton G. B., Hughes J. L. Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site. Nature. 329:1987a;547-549.
22. Milich D. R., McLachlan A., Moriarty A., Thornton G. B. Immune response to hepatitis B virus core antigen (HBcAg): Localization of T cell recognition sites within HBcAg/HBeAg. J. Immunol. 139:1987b;1223-1231.
23. Milich D. R., McLachlan A., Stahl S., Wingfield P., Thornton G. B., Hughes J. L., Jones J. E. Comparative immunogenicity of hepatitis B virus core and E antigens. J. Immunol. 141:1988;3617-3624.
24. Milich D. R., Jones J. E., McLachlan A., Houghten R., Thornton G. B., Hughes J. L. Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants. Influence of peptide-MHC interaction. J. Immunol. 143:1989;3148-3156.
25. Milich D. R., Jones J., Hughes J., Price J., Raney A., McLachlan A. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc. Natl. Acad. Sci. USA. 87:1990;6599-6603.
26. Milich D. R., Schodel F., Hughes J. L., Jones J. E., Peterson D. L. The hepatitis B virus core and e antigens elicit different Th cell subsets: Antigen structure can affect Th cell phenotype. J. Virol. 71:1997;2192-2201.
27. Milich D. R., Chen M. K., Hughes J. L., Jones J. E. The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence. J. Immunol. 160:1998;2013-2021.
28. Moreau M. C., Gaboriau-Routhiau V. The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice. Res. Immunol. 147:1996;49-59.
29. Ogata H. J., Miller R., Ishak K., Purcell R. The complete nucleotide sequence of a pre-core mutant of hepatitis B virus implicated in fulminant hepatitis and its biological characterization in chimpanzees. Virology. 194:1993;263-276.
30. Okada K., Kamiyama I., Inomata M., Imai M., Miyakawa Y., Mayumi M. E antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N. Engl. J. Med. 294:1976;946-949.
31. Ou J., Laub O., Rutter W. Hepatitis B virus gene function: The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc. Natl. Acad. Sci. USA. 83:1986;1578-1582.
32. Peng H. J., Turner M. W., Strobel S. The generation of a 'tolerogen' after the ingestion of ovalbumin is time-dependent and unrelated to serum levels of immunoreactive antigen. Clin. Exp. Immunol. 81:1990;510-515.
33. Peng H. J., Chang Z. N., Han S. H., Won M. H., Huang B. T. Chemical denaturation of ovalbumin abrogates the induction of oral tolerance of specific IgG antibody and DTH responses in mice. Scand. J. Immunol. 42:1995;297-304.
34. Reifenberg K., Löhler J., Pudollek H., Schmitteckert E., Spindler G., Kock J., Schlicht H. J. Long term expression of the hepatitis B virus core- e- and X-proteins does not cause organ pathology in transgenic mice. J. Hepatol. 26:1997;119-230.
35. Reifenberg K., Deutschle T., Wild J., Hanano R., Gastrock-Balitsch I., Schirmbeck R., Schlicht H.-J. The hepatitis B virus e antigen cannot pass the murine placenta efficiently and does not induce CTL immune tolerance in H-2b mice in utero. Virology. 243:1998;45-53.
36. Reifenberg K., Wilts H., Löhler J., Nusser P., Hanano R., Guidotti L. G., Chisari F. V., Schlicht H.-J. The hepatitis B virus X-protein transactivates viral core gene expression in vivo. J. Virol. 73:1999;10399-10405.
37. + T-helper and a T-killer cell. Nature. 393:1998;474-478.
38. Schlicht H. J., Salfeld J., Schaller H. The pre-C region of the duck hepatitis B virus encodes a signal sequence which is essential for the synthesis and secretion of processed core proteins but not for virus formation. J. Virol. 61:1987;3701-3709.
39. Schlicht H. J., Schaller H. The secretory core protein of human hepatitis B virus is expressed on the cell surface. J. Virol. 63:1989;5399-5404.
40. Schoenberger S. P., Toes R. E., van der Voort E. I., Offringa R., Melief C. J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 393:1998;480-483.
41. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:1993;10188-10192.
42. Terazawa S., Kojima M., Yamanaka T., Yotsumoto S., Okamoto H., Tsuda F., Miyakawa Y., Mayumi M. Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis and their mothers positive for antibody to hepatitis B e antigen. Pediatr. Res. 29:1991;5-9.
43. + cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B virus core and e antigens. J. Virol. 71:1997;3365-3374.
44. Yang X., Cui M. X., Liu B. G. Breast-feeding by mothers with positive serum hepatitis B virus test. Chung Hua Fu Chan Ko Tsa Chih. 29:1994;586-588.