Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 6, 2000, Pages 547-549

  Perrey, David A ^a   Narla, Rama Krishna ^a   Uckun, Fatih M ^a  

^a Parker Hughes Cancer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE CHLOROMETHYL KETONE; CYSTEINE DIAZOMETHYL KETONE; KETONE DERIVATIVE; N ACETYL S DODECYL CYSTEINE CHLOROMETHYL KETONE; N ACETYL S FARNESYL CYSTEINE CHLOROMETHYL KETONE; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; B LYMPHOBLAST; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; STRUCTURE ACTIVITY RELATION; T LYMPHOBLAST;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; CELL LINE; COLORING AGENTS; CYSTEINE; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034689186     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00046-9     Document Type: Article

References (13)

1. Uckun F.M., Kersey J.H., Haake R., Weisdorf D., Nesbit M.E., Ramsay N.K. N. Engl. J. Med. 329:1993;1296.
2. Uckun F.M., Sather H.N., Gaynon P.S., Arthur D.C., Trigg M.E., Tubergen D.G., Nachman J., Steinherz P.G., Sensel M.G., Reaman G.H. Blood. 90:1997;28.
3. Uckun F.M., Sensel M.G., Sun L., Steinherz P.G., Trigg M.E., Heerema N.A., Sather H.N., Reaman G.H., Gaynon P.S. Blood. 91:1998;735.
4. Uckun F.M., Herman-Hatten K., Crotty M.L., Sensel M.G., Sather H.N., Tuel-Ahlgren L., Sarquis M.B., Bostrom B., Nachman J.B., Steinherz P.G., Gaynon P.S., Heerema N. Blood. 92:1998;810.
5. Nachman J.B., Sather H.N., Sensel M.G., Trigg M.E., Cherlow J.M., Lukens J.N., Wolff L., Uckun F.M., Gaynon P.S. N. Engl. J. Med. 338:1998;1663.
6. Brown M.J., Milano P.D., Lever D.C., Epstein W.W., Poulter C.D. J. Am. Chem. Soc. 113:1991;3176.
7. Green G.D.J., Shaw E. J. Biol. Chem. 256:1981;1923.
8. Chen Y., Ma Y.-T., Rando R.R. Biochemistry. 35:1996;3227.
9. -1; MS (MALDI-TOF): m/z 364.9 (M+1), 328.9 (M-Cl).
10. Narla R.K., Liu X.P., Myers D.E., Uckun F.M. Clin. Cancer Res. 4:1998;1405.
11. Uckun F.M., Evans W.E., Forsyth C.J., Waddick K.G., Tuel-Ahlgren L., Chelstrom L.M., Burkhardt A., Bolen J., Myers D.E. Science. 267:1995;886.
12. Mahajan S., Ghosh S., Sudbeck E.A., Zheng Y., Downs S., Hupke M., Uckun F.M. J. Biol. Chem. 274:1999;9587.
13. Uckun F., Chandan-Langlie M., Dockham P.A., Aeppi D., Sladek N.E. Leukemia and Lymphoma. 13:1994;417.