Molecular computation by DNA hairpin formation

Science

Volumn 288, Issue 5469, 2000, Pages 1223-1226

  Sakamoto, Kensaku ^a   Gouzu, Hidetaka ^a   Komiya, Ken ^a   Kiga, Daisuke ^a,c   Yokoyama, Shigeyuki ^a   Yokomori, Takashi ^b   Hagiya, Masami ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b WASEDA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SINGLE STRANDED DNA;

ALGORITHM; ARTICLE; DNA FLANKING REGION; DNA TEMPLATE; MOLECULAR BIOLOGY; POINT MUTATION; PRIORITY JOURNAL; RESTRICTION SITE; THERMOREGULATION;

ALGORITHMS; BIOTINYLATION; COMPUTATIONAL BIOLOGY; DNA LIGASES; DNA, SINGLE-STRANDED; DNA-DIRECTED DNA POLYMERASE; ELECTROPHORESIS, AGAR GEL; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; POLYMERASE CHAIN REACTION; TEMPERATURE; TEMPLATES, GENETIC;

EID: 0034685812     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5469.1223     Document Type: Article

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31. These additional data came from the 64 sequenced clones picked up from pools 1 through 3 and 9 clones from other prototype computations. These 73 clones include 71 different literal strings.
32. We thank A. Nishikawa for designing the DNA sequences used in the experiments, E. Winfree for the critical reading of the manuscript, and Y. Husimi for valuable discussions on the physicochemical nature of hairpins. This work was supported in part by the Japan Society for the Promotion of Science under the Research for the Future program (JSPS-RFTF 96100101).