Effect of dimethylsphingosine on muscarinic M3 receptor signalling in SH-SY5Y cells

European Journal of Pharmacology

Volumn 402, Issue 1-2, 2000, Pages 55-59

  Young, Kenneth W ^a   Channing, Deborah R ^a   Nahorski, Stefan R ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Ca2+ mobilisation; Dimethylsphingosine; Ins(1,4,5)P3; Muscarinic receptor; SH SY5Y neuroblastoma cell; Sphingosine 1 phosphate

Indexed keywords

CALCIUM; G PROTEIN COUPLED RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE; METHACHOLINE; METHYLSCOPOLAMINE; MUSCARINIC M3 RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE DERIVATIVE; SPHINGOSINE KINASE;

ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION;

BRAIN NEOPLASMS; CALCIUM; CELL LINE; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INOSITOL 1,4,5-TRISPHOSPHATE; LYSOPHOSPHOLIPIDS; METHACHOLINE CHLORIDE; MUSCARINIC AGONISTS; N-METHYLSCOPOLAMINE; NEUROBLASTOMA; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 0034683185     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00509-4     Document Type: Article

References (16)

1. Alemany R., Meyer zu Heringdorf D., Van Koppen C.J., Jakobs K.H. Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. J. Biol. Chem. 274:1999;3994-3999.
2. 3H]-inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes: characterization and validation of a radioreceptor assay. Biochem. J. 265:1990;421-427.
3. εRI antigen. Nature. 380:1996;634-636.
4. Edsall L.C., van Brocklyn J.R., Cuvillier O., Kleuser B., Spiegal S. N,N-Dimethylsphingosine is a potent inhibitor of sphingosine kinase but not protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry. 37:1998;12892-12898.
5. Ghosh T.K., Bian J., Gill D.L. Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science. 248:1990;1653-1656.
6. Ghosh T.K., Bian J., Gill D.L. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J. Biol. Chem. 269:1994;22628-22635.
7. Hla T., Lee M.-J., Ancellin N., Liu C.H., Thangada S., Thompson B.D., Kluk M. Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? Biochem. Pharmacol. 58:1999;201-207.
8. 2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y. Biochem. J. 265:1990;555-562.
9. 2+-signalling in a human neuroblastoma cell line revealed by cellular differentiation. Br. J. Pharmacol. 126:1999;1559-1566.
10. CRAC) is a direct target for sphingosine. J. Biol. Chem. 273:1998;25020-25030.
11. Meyer zu Heringdorf D., van Koppen C.J., Jakobs K.H. Molecular diversity of sphingolipid signalling. FEBS Lett. 410:1997;34-38.
12. 2+ signalling by G-protein-coupled receptors. EMBO J. 17:1998;2830-2837.
13. Olivera A., Spiegel S. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature. 365:1993;557-560.
14. 2+ store depletion? Mol. Pharmacol. 47:1995;509-516.
15. Willars G.B., Nahorski S.R., Challiss R.A.J. Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells. J. Biol. Chem. 273:1998;5037-5046.
16. 2+ mobilisation in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation. Biochem. J. 343:1999;45-52.