The antioxidant drug dipyridamole spares the vitamin E and thiols in red blood cells after oxidative stress

Cardiovascular Research

Volumn 47, Issue 3, 2000, Pages 510-514

  Kusmic, Claudia ^a   Picano, Eugenio ^a   Busceti, Carla Letizia ^b   Petersen, Christina ^c   Barsacchi, Renata ^b  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

Free radicals

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CUMENE HYDROPEROXIDE; DIPYRIDAMOLE; FREE RADICAL; THIOL;

ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; FLUORESCENCE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VITAMIN METABOLISM;

ANTIOXIDANTS; BENZENE DERIVATIVES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; DIPYRIDAMOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; HUMANS; LIPID PEROXIDATION; OXIDATIVE STRESS; SULFHYDRYL COMPOUNDS; VITAMIN E;

EID: 0034683027     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00058-4     Document Type: Article

References (30)

1. FitzGerald G.A. Dipyridamole. N Engl J Med. 316:1987;1247-1257.
2. Di Salvo T.G., Webster M.W.I., Chesebro J.H., Fuster V. Messerli F. Cardiovascular drug therapy. 1996;1451-1465 W.B. Saunders, Philadelphia.
3. Diner H.C. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 143:1996;1-13.
4. Picano E., Abbracchio M.P. European Stroke Prevention Study-2 results: serendipitous demonstration of neuroprotection induced by endogenous adenosine accumulation? TiPS. 19:1998;14-16.
5. Rajah S.M., Penny A.F., Crow M.J., Pepper M.D., Watson D.A. The interaction of varying doses of dipyridamole and acetylsalicylic acid on the inhibition of platelet functions and their effect on bleeding time. Br J Clin Pharmaco. 8:1979;483-489.
6. Neri Serneri G.G.N., Masotti G., Poggesi L., Galanti G., Morettini A. Enhanced prostacyclin production by dipyridamole in man. Eur J Clin Pharmacol. 21:1981;9-15.
7. Sinzinger H., Silberbauer K. Dose-dependent increase in prostacyclin synthesis from various vascular tissues by dipyridamole. Wien Klin Wochenschr. 94:1982;630-632.
8. Constantini V., Talpacci A., Bastiano M.L., Boschetti E., Cipolloni S., Bisacci R., Nenci G.G. Increased prostacyclin production from human veins by dipyridamole: An in-vitro and ex-vivo study. Biomed Biochim Acta. 49:1990;263-271.
9. Rajah S.M., Crow M.J., Penny A.F., Ahmad R., Watson D.A. The effect of dipyridamole on platelet in man. Brit J Pharmacol. 4:1977;129-133.
10. Dresse A., Chevol C., Delapierre D., Masset H., Weiseberger H., Bozler C., Heinzel G. Pharmacokinetics of oral dipyridamole (Persantin) and its effect on platelet adenosine uptake in man. Eur J Clin Pharmacol. 23:1982;229-234.
11. Iuliano L., Pedersen J., Rotilio G., Ferro D., Violi F. A potent chain breaking activity of the cardiovascular drug dipyridamole. Free Rad Biol Med. 18:1995;239-247.
12. Pedulli G.F., Lucarini M., Marchesi E., Paolucci F., Roffia S., Fiorentini D., Landi L. Medium effects on the antioxidant activity of dipyridamole. Free Rad Biol Med. 26:1999;295-302.
13. Esterbauer H., Jurgens G., Quehenberger O., Koller E. Autooxidation of human low density lipoprotein: Loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J Lipid Res. 28:1987;495-509.
14. Steinbrecher U.P. Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J Biol Chem. 262:1987;3603-3608.
15. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witzum J.L. Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 320:1989;915-931.
16. Werns S.W., Shea M.J., Lucchesi B.R. Free radicals in ischemic myocardial injury. J Free Rad Biol Med. 1:1985;103-110.
17. Cohen M.V. Free radicals in ischemic and reperfusion myocardial injury: Is this the time for clinical trials? Ann Int Med. 320:1989;918-931.
18. Rice-Evans C., Omorphos S.C., Baysal E. Sickle cell membranes and oxidative damage. Biochem J. 237:1974;265-269.
19. Chiu D., Kuypers F., Lubin B. Lipid peroxidation in human red cells. Semin Hematol. 26:1989;257-276.
20. Hebbel R.P. Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology. Blood. 77:1991;214-237.
21. Sies H. Oxidative stress. 1985;Academic Press, London.
22. Koster J.F., Slee R.G. Lipid peroxidation of human erythrocytes ghosts induced by organic hydroperoxides. Biochim Biophys Acta. 752:1983;233-239.
23. van der Laarse A., Julicher R.H.M., Sterrenberg L., Bloys van Treslong C.H.F. Lipid peroxidation in neonatal heart cell cultures: Effect of cumene hydroperoxide. Cardiovasc Res. 20:1986;20-25.
24. van den Berg J.J.M., Op den Kamp J.A.F., Lubin B.H., Roelofsen B., Kuypers F.A. Kinetics and site specificity of hydroperoxide-induced oxidative damage in red blood cells. Free Rad Biol Med. 12:1992;487-498.
25. van den Berg J.J.M., Kuypers F.A., Lubin B.H., Roelofsen B., Op den Kamp J.A.F. Direct and continuous measurement of hydroperoxide-induced oxidative stress on the membrane of intact erythrocytes. Free Rad Biol Med. 11:1991;255-261.
26. Beutler E. Red cell metabolism. A manual of biochemical methods. 1975;Grune and Stratton, New York.
27. Lang J.K., Gohill R., Packer L. Simultaneous determination of tocopherols, ubiquinols and ubiquinones in blood, plasma, tissues and subcellular fractions. Anal Biochem. 157:1986;106-116.
28. Nassar P.M., Almeida L.E., Tabak M. Binding of dipyridamole to phospholipid vesicles: a fluorescent study. Biochim Biophys Acta. 1328:1997;140-150.
29. Iuliano L., Colavita A.R., Camastra C., Bello V., Quintarelli C., Alessandroni M., Piovella F., Violi F. Protection of low density protein oxidation at chemical and cellular level by the antioxidant drug dipyridamole. Brit. J. Pharmacol. 119:1996;1438-1446.
30. Di Perri T., Laghi-Pasini F. Di Perri T., Laghi-Pasini F. Fisiologia e farmacologia del sistema adenosinico. 1991;179-189. Luigi Pozzi Edition.