Cardiac gap junction remodeling by stretch: Is it a good thing?

Circulation Research

Volumn 87, Issue 4, 2000, Pages 272-274

  Morley, Gregory E ^a   Jalife, José ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Cell to cell communication; Conduction velocity; Immunohistochemistry; Mechanical forces; Optical mapping; Pulsatile stress

Indexed keywords

EDITORIAL; GAP JUNCTION; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0034682934     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.4.272     Document Type: Editorial

References (21)

1. Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes
2. Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy
3. Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes: Possible role of protein kinase C activation
4. Stretching cardiac myocytes stimulates protooncogene expression
5. Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes
6. Regulation of cardiac myocyte protein turnover and myofibrillar structure in vitro by specific directions of stretch
7. Stretch activated ion channels in ventricular myocytes
8. Dose-dependent inhibition of stretch-induced arrhythmias by gadolinium in isolated canine ventricles: Evidence for a unique mode of antiarrhythmic action
9. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: Potential involvement of an autocrine/paracrine mechanism
10. Pulsatile stretch remodels cell-to-cell communication in cultured myocytes
11. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling
12. Slow conduction in cardiac tissue, I: Effects of a reduction of excitability versus a reduction of electrical coupling on microconduction
13. Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43
14. Cardiac myocytes express multiple gap junction proteins
15. Effects of diminished expression of connexin43 on gap junction number and size in ventricular myocardium
16. Regulation of connexin 43 gene expression by cyclical mechanical stretch in neonatal rat cardiomyocytes
17. Structure of connexin43 and its regulation by pHi
18. Gap junctions in cardiovascular disease
19. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts
20. Changes in cell-to-cell electrical coupling associated with left ventricular hypertrophy
21. Abnormal action potential conduction in isolated human hypertrophied left ventricular myocardium