Complement-mediated antiinflammatory action of extracts and pure secoiridoids isolated from Fraxinus species

Phytotherapy Research

Volumn 10, Issue 7, 1996, Pages 555-558

  Ivanovska, Nina ^a   Iossifova, Tanya ^b   Kostova, Ivanka ^b  

^a INSTITUTE OF MICROBIOLOGY   (Bulgaria)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

Author keywords

Anticomplement activity; Antiinflammatory; Fraxinus species; Secoiridoids

Indexed keywords

ALCOHOL; FRAXINUS EXTRACT; PLANT EXTRACT; SECOIRIDOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHROMATOGRAPHY; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT INHIBITION; COMPLEMENT SYSTEM; CONTROLLED STUDY; DRUG ISOLATION; GUINEA PIG; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PAW EDEMA; SERUM; SPECTROSCOPY; TRADITIONAL MEDICINE;

FRAXINUS;

EID: 0029850858     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199611)10:7<555::AID-PTR908>3.0.CO;2-S     Document Type: Article

References (13)

1. Ansari, R. A., Aswal, B. S., Chander, R. et al. (1988). Hepatoprotective activity of kutkin - the iridoid glycoside mixture of Picrorhiza kurrooa. Indian J. Med. Res. 87, 401-404.
2. Frank, M. M., and Fries, L. F. (1991). The role of complement in inflammation and phagocytosis. Immunol. Today 12, 322-326.
3. Goldstein, I. M. (1988). In, Inflammation: Basic Principles and Clinical Correlates, ed. by J. I. Gllin, I. M. Goldstein and R. Synderman, pp. 55-74. Raven Press, New York.
4. Ivanovska, N., Iossifova, T., Vassileva, E., and Kostova, I. (1994). Effect of some hydroxycoumarins on complement-mediated hemolysis in human serum. Meth. Find. Exp. Clin. Pharmacol. 16, 557-562.
5. Iossifova, T., Mikhova, B., and Kostova, I. (1993). A secoiridoid glucoside and a phenolic compound from F. ornus bark. Phytochemistry 34, 1373-1376.
6. Klerx, J. P. A. M., Beukelman, C. J., van Dijk, H., and Willers, J. M. N. (1983). Microassay for colorimetric estimation of complement activity in guinea pig, human and mouse serum. J. Immunol. Meth. 63, 215-220.
7. Kostova, I., Dinchev, D. Mikhova, B., and Iossifova, T. (1995). Epoxyconiferyl alcohol from F. oxycarpa bark. Phytochemistry 38, 801-802.
8. Kostova, I., Iossifova, T., Vassileva, E., and Mikhova, B. (1993). Secoiridoids and phenolic compounds from F. ornus. Planta Med. 59, A705.
9. Morgan, B. P. (1990). The biological effects of complement activation. In Complement: Clinical Aspects and Relevance to Disease, pp. 36-56. Academic Press, Orlando, FL.
10. Singh, G. B., Bani, S., Singh, S. et al. (1993). Antiinflammatory activity of the iridoids kutkin, picroside-1 and kutkoside from Picrorhiza kurrooa. Phytother. Res. 7, 402-407.
11. Stefanova, Z., Neychev, H., Ivanovska, N., and Kostova, I. (1995). Effect of a total extract from Fraxinus ornus stem bark and esculin on zymosan- and carrageenan-induced paw oedema in mice. J. Ethnopharmacol. 46, 101-106.
12. Stoyanov, N. (1973). In Bulgarian Medicinal Plants, pp. 321-322. Nauka i Izkustvo, Sofia (in Bulgarian).
13. Van Dijk, H., Rademaker, P. M., Klerx, J. P. A. M., and Willers, J. M. N. (1985). Study of the optimal reaction conditions for assay of the mouse alternative complement pathway. J. Immun. Meth. 85, 233-243.