Kinetic characterisation of ene-diol-based inhibitors of α-amylase

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 14, 2000, Pages 1575-1576

  Gerrard, Juliet A ^a   Prince, Maureen J ^a   Abell, Andrew D ^a  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; AMYLASE INHIBITOR; ASCORBIC ACID; DIHYDROXYFUMARIC ACID;

ARTICLE; ENZYME INHIBITION; INHIBITION KINETICS; PHARMACOPHORE;

ALPHA-AMYLASE; ASCORBIC ACID; CEREALS; ENZYME INHIBITORS; KINETICS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034679650     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00288-2     Document Type: Article

References (14)

1. Heightman T.D., Vasella A.T. Angew. Chem., Int. Ed. 38:1999;750.
2. Takahashi, H. European Patent Application No. 92101636.6, 1992.
3. Tormo, M. A.; Ropero, F.; Nieto, M.; Martinez, I.; Campillo, J. E. Phytotherapy Res. 1997, 11, 39. Choudhury, A.; Maeda, K.; Murayama, R.; Dimagno, D. P. Gastroenterology 1996, 111, 1313.
4. Tormo, M. A.; Ropero, F.; Nieto, M.; Martinez, I.; Campillo, J. E. Phytotherapy Res. 1997, 11, 39. Choudhury, A.; Maeda, K.; Murayama, R.; Dimagno, D. P. Gastroenterology 1996, 111, 1313.
5. Nahoum, V.; Roux, G.; Anton, V.; Rouge, P.; Puigserver, A.; Bischoff, H.; Henrissat, B.; Payan, F. Biochem. J. 2000, 346, 201. Kadziola, A.; Sogaard, M.; Svensson, B.; Haser, R. J. Mol. Biol. 1998, 278, 205. Brzozowski, A. M.; Davies, G. J. Biochemistry 1997 36,10837.
6. Nahoum, V.; Roux, G.; Anton, V.; Rouge, P.; Puigserver, A.; Bischoff, H.; Henrissat, B.; Payan, F. Biochem. J. 2000, 346, 201. Kadziola, A.; Sogaard, M.; Svensson, B.; Haser, R. J. Mol. Biol. 1998, 278, 205. Brzozowski, A. M.; Davies, G. J. Biochemistry 1997 36,10837.
7. Nahoum, V.; Roux, G.; Anton, V.; Rouge, P.; Puigserver, A.; Bischoff, H.; Henrissat, B.; Payan, F. Biochem. J. 2000, 346, 201. Kadziola, A.; Sogaard, M.; Svensson, B.; Haser, R. J. Mol. Biol. 1998, 278, 205. Brzozowski, A. M.; Davies, G. J. Biochemistry 1997 36,10837.
8. Uchida R., Nasu A., Tokutake S., Kasai K., Tobe K., Yamaji N. Chem. Pharm. Bull. 47:1999;187.
9. Abell A.D., Ratcliffe M.J., Gerrard J.A. Bioorg. Med. Chem. Lett. 8:1998;1703.
10. Palla J.-C., Verrier J. Ann. Tech. Agric. 23:1974;151.
11. Sheehan H., McCleary B.V. Biotechnol. Tech. 2:1988;289.
12. -3 M. All measurements were made in triplicate.
13. Enzfitter returned ambiguous results for the mode of inhibition by 2, suggesting that derivatisation at the 5 and 6 positions may interfere with pure competitive binding.
14. Truscheit E., Frommer W., Junge B., Muller L., Schmidt D.D., Wingender W. Angew. Chem., Int. Ed. Engl. 20:1981;744.