Characterization of a low molecular weight isoform of IL-1 receptor antagonist

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1997-2003

  Malyak, Mark ^a   Guthridge, Joel M ^a   Hance, Kenneth R ^a   Dower, Steven K ^b,c   Freed, John H ^a,d   Arend, William P ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c AMGEN INC   (United States)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RABBIT; RETICULOCYTE LYSATE; SITE DIRECTED MUTAGENESIS; TRANSLATION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; ISOMERISM; LYMPHOCYTE ACTIVATION; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RABBITS; RECEPTORS, INTERLEUKIN-1; RETICULOCYTES; SEQUENCE ANALYSIS; SIALOGLYCOPROTEINS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032529416     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Dinarello, C. A., and S. M. Wolff. 1993. The role of interleukin-1 in disease. N. Engl. J. Med. 328:106.
2. Arend, W. P., and J.-M. Dayer. 1995. Inhibition of the production and effects of interleukin-1 and TNF α in rheumatoid arthritis. Arthritis Rheum. 38:151.
3. Arend, W. P. 1993. Interleukin-1 receptor antagonist. Adv. Immunol. 54:167.
4. Lennard, A. C. 1995. Interleukin-1 receptor antagonist. Crit. Rev. Immunol. 15: 77.
5. Malyak, M., R. E. Swaney, and W. P. Arend. 1993. Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies: potential contribution from synovial fluid neutrophils. Arthritis Rheum. 36:781.
6. Fischer, E., K. J. Van Zee, M. A. Marano, C. S. Rock, J. S. Kenney, D. D. Poutsiaka, C. A. Dinarello, S. F. Lowry, and L. L. Moldawer. 1992. Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Blood 79:2196.
7. Firestein, G. S., D. L. Boyle, C. Yu, M. M. Paine, T. D. Whisenand, N. J. Zvaifler, and W. P. Arend. 1994. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 37:644.
8. Miller, L. C., E. A. Lynch, S. Isa, J. W. Logan, C. A. Dinarello, and A. C. Steere. 1993. Balance of synovial fluid IL-1β and IL-1 receptor antagonist and recovery from Lyme arthritis. Lancet 341:146.
9. Smith, D. R., S. L. Kunkel, T. J. Standiford, M. W. Rolfe, J. P. Lynch III, D. A. Arenberg, C. A. Wilke, M. D. Burdick, F. J. Martinez, J. N. Hampton, R. I. Whyte, M. B. Orringer, and R. M. Strieter. 1995. Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis: a compartmentalized analysis. Am. J. Respir. Crit Care Med. 151:1965.
10. Chomarat, P., E. Vannier, J. Dechanet, M. C. Rissoan, J. Banchereau, C. A. Dinarello, and P. Miossec. 1995. Balance of IL-1 receptor antagonist/IL-1β in rheumatoid synovium and its regulation by IL-4 and IL-10. J. Immunol. 154: 1432.
11. Cominelli, F., C. C. Nast, B. D. Clark, R. Schindler, R. Llerna, V. E. Eysselein, R. C. Thompson, and C. A. Dinarello. 1990. Interleukin-1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J. Clin. Invest. 86:972.
12. Joosten, L. A. B., M. M. A. Helsen, F. A. van de Loo, and W. B. van den Berg. 1996. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNFα, anti-IL-1α/β, and IL-1Ra. Arthritis Rheum. 39:797.
13. Eisenberg, S. P., R. J. Evans, W. P. Arend, E. Verderber, M. T. Brewer, C. H. Hannum, and R. C. Thompson. 1990. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343:341.
14. Haskill, S., G. Martin, L. Van Le, J. Morris, A. Peace, C. F. Bigler, G. J. Jaffe, C. Hammerberg, S. A. Sporn, S. Fong, W. P. Arend, and P. Ralph. 1991. cDNA cloning of an intracellular form of the human interleukin-1 receptor antagonist associated with epithelium. Proc. Natl. Acad. Sci. USA 88:3681.
15. Smith, M. F., Jr., D. Eidlen, M. T. Brewer, S. P. Eisenberg, W. P. Arend, and A. Gutierrez-Hartmann. 1992. The human IL-1 receptor antagonist promoter: cell type-specific activity and identification of regulatory regions. J. Immunol. 149: 2000.
16. Smith, M. F., Jr., D. Eidlen, W. P. Arend, and A. Gutierrez-Hartmann. 1994. LPS- induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements. J. Immunol. 153:3584.
17. Jenkins, J. K., R. F. Drong, M. E. Shuck, M. J. Bienkowski, J. L. Slightom, W. P. Arend, and M. F. Smith, Jr. 1997. Intracellular interleukin-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions. J. Immunol. 158:748.
18. Bigler, C. F., D. A. Norris, W. L. Weston, and W. P. Arend. 1992. Interleukin-1 receptor antagonist production by human keratinocytes. J. Invest. Dermatol. 98: 38.
19. Kennedy, M. C., J. T. Rosenbaum, J. Brown, S. R. Planck, K. Huang, C. A. Armstrong, and J. C. Ansel. 1995. Novel production of interleukin-1 receptor antagonist peptides in normal human cornea. J. Clin. Invest. 95:82.
20. Gabay, C., M. F. Smith, Jr., D. Eidlen, and W. P. Arend. 1997. Interleukin-1 receptor antagonist (IL-1Ra) is an acute phase protein. J. Clin. Invest. 99:2930.
21. Malyak, M., M. F. Smith, Jr., A. A. Abel, K. R. Hance, and W. P. Arend. 1998. The differential production of three forms of interleukin-1 receptor antagonist. J. Immunol. 161:2004.
22. Harlow, C., and D. Lane. 1988. Immunoaffinity purification. In Antibodies: A Laboratory Manual. C. Harlow, and D. Lane, eds. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 511.
23. Arend, W. P., M. Malyak, M. F. Smith, Jr., T. D. Whisenand, J. L. Slack, J. E. Sims, J. G. Gin, and S. K. Dower. 1994. Binding of IL-1α, IL-1/β, and IL-1Ra by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J. Immunol. 153:4766.
24. Gabay, C., B. Porter, G. Fantuzzi, and W. P. Arend. 1997. Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo. J. Immunol. 159:5905.
25. Malyak, M., F. G. Joslin, E. L. Verderber, S. P. Eisenberg, and W. P. Arend. 1991. IL-1Ra ELISA: reduction and alkylation of synovial fluid eliminates interference by IgM rheumatoid factors. J. Immunol. Methods 140:281.
26. Goto, F., K. Goto, T. Miyata, S. Ohkawara, T. Takao, S. Mori, S. Furukawa, T. Maeda, S. Iwanaga, Y. Shimonishi, and M. Yoshinaga. 1992. Interleukin-1 receptor antagonist in inflammatory exudate cells of rabbits: production, purification and determination of primary structure. Immunology 77:235.
27. Matsukawa A., S. Mori, S. Ohkawara, T. Maeda, S. Tanase, S. Edamitsu, F. Yanagi, and M. Yoshinaga. 1992. Production, purification and characterization of a rabbit recombinant IL-1 receptor antagonist. Biomed. Res. 13:269.
28. Scholer, H. R., S. Ruppert, N. Suzuki, K. Chowdhury, and P. Gruss. 1990. New type of POU domain in germ line-specific protein Oct-4. Nature 344:435.
29. Voss, J. W., T.-P. Yao, and M. G. Rosenfeld. 1991. Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. J. Biol. Chem. 266:12832.
30. Delmas, V., B. M. Laoide, D. Masquiler, R. P. de Groot, N. S. Foulkes, and P. Sassone-Corsi. 1992. Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions. Proc. Natl. Acad. Sci. USA 89:4226.
31. Susuki, T., T. Yoshida, and S. Tuboi. 1992. Evidence that rat liver mitochondrial and cytosolic fumarases are synthesized from one species of mRNA by alternative translational initiation at two in-phase AUG codons. Eur. J. Biochem. 207: 767.
32. Schreiber, E., A. Tobler, U. Malipiero, W. Schaffner, and A. Fontana. 1993. cDNA cloning of human N-Oct 3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. Nucleic Acids Res. 21:253.
33. Aoki, M., F. Hamada, T. Sugimoto, S. Sumida, T. Akiyama, and K. Toyoshima. 1993. The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. J. Biol. Chem. 268:22723.
34. Hann, S. R., M. Dixit, R. C. Sears, and L. Sealy. 1994. The alternatively initiated c-Myc proteins differentially regulate transcription through a noncanonical DNA-binding site. Genes Dev. 8:2441.
35. Garnier, G., A. Circolo, and H. R. Colten. 1995. Translational regulation of murine complement factor B alternative transcripts by upstream AUG codons. J. Immunol. 154:3275.
36. Calligaris, R., S. Bottardi, S. Cogoi, I. Apezteguia, and C. Santoro. 1995. Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor. Proc. Natl. Acad. Sci. USA 92.-11598.
37. Kumar, P., S. M. Van Patten, and A. Walsh. 1997. Multiplicity of the β form of the cAMP-dependent protein kinase inhibitor protein generated by post-translational modification and alternate translational initiation. J. Biol. Chem. 272:20011.
38. Vagner, S., M.-C. Gensac, A. Maret, F. Bayard, F. Amalric, H. Prats, and A.-C. Prats. 1995. Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes. Mol. Cell. Biol. 15:35.
39. Kozak, M. 1995. Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. Proc. Natl. Acad. Sci. USA 92:2662.
40. Brown, E. J., and S. L. Schreiber. 1996. A signaling pathway to translational control. Cell 86:517.
41. Sachs, A. B., P. Sarnow, and M. W. Hentze. 1997. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89:831.
42. Muzio, M., N. Polentarutti, M. Sironi, G. Poli, L. De Gioia, M. Introna, A. Montovani, and F. Colotta. 1995. Cloning and characterization of a new isoform of the interleukin-1 receptor antagonist. J. Exp. Med. 182:623.
43. Evans, R. J., J. Bray, J. D. Childs, G. P. A. Vigers, B. J. Brandhuber, J. J. Skalicky, R. C. Thompson, and S. P. Eisenberg. 1995. Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1β by site-directed mutagenesis: identification of a single site in IL-1Ra and two sites in IL-1β. J. Biol. Chem. 270:11477.
44. Arend, W. P., H. G. Welgus, R. C. Thompson, and S. P. Eisenberg. 1990. Biological properties of recombinant human monocyte-derived IL-1 receptor antagonist. J. Clin. Invest. 85:1694.
45. Maier, J. A. M., P. Voulalas, D. Roeder, and T. Maciag. 1990. Extension of the life-span of human endothelial cells by an interleukin-1α antisense oligomer. Science 249:1570.
46. Maier, J. A. M., M. Statuto, and G. Ragnotti. 1994. Endogenous interleukin-1α must be transported to the nucleus to exert its activity in human endothelial cells. Mol. Cell. Biol. 14:1845.
47. Watson, J. M., A. K. Lofquist, C. A. Rinehart, J. C. Olsen, S. S. Makarov, D. G. Kaufman, and J. S. Haskill. 1995. The intracellular IL-1 receptor antagonist alters IL-1-inducible gene expression without blocking exogenous signaling. J. Immunol. 155:4467.