3'-β-ethynyl and 2'-deoxy-3'-β-ethynyl adenosines: First 3'-β- branched-adenosines substrates of adenosine deaminase

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 2, 2000, Pages 139-141

  Tritsch, Denis ^a   Jung, Pierre M J ^a   Burger, Alain ^a   Biellmann, Jean François ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; ADENOSINE DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DEAMINATION; ENZYME CONFORMATION; HYDROGENATION; KINETICS; NONHUMAN;

EID: 0034677062     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00639-3     Document Type: Article

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5. +; 100).
6. 7 All the double reciprocal substrate-initial velocity plots were linear. Enzyme (0.14 μg for adenosine and 2′-deoxy-adenosine; 1.4 μg for compounds 4-7; 5.6 μg for 1 and until 22.4 μg for 2 and 3) was added to initiate the enzymatic reaction.
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24. Weltin, D.; Jung, P. M. J.; Holl, V.; Dauvergne, J.; Burger, A.; Dufour, P.; Aubertin, A. M.; Bischoff, P.; Biellmann, J.-F. unpublished results.