Down-regulation of bcr-abl and bcl-x(L) expression in a leukemia cell line and its doxorubicin-resistant variant by topoisomerase II inhibitors

Biochemical Pharmacology

Volumn 60, Issue 12, 2000, Pages 1823-1828

  Laroche Clary, Audrey ^a   Larrue, Annick ^a   Robert, Jacques ^a  

^a INSTITUT BERGONIÉ   (France)

Author keywords

Amsacrine; Apoptosis; bcl x(L) gene; bcr abl gene; Chronic myeloid leukemia; Topoisomerase II

Indexed keywords

AMSACRINE; BCR ABL PROTEIN; DNA FRAGMENT; DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BCL X; RNA;

APOPTOSIS; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG CYTOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMSACRINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA TOPOISOMERASES, TYPE II; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; ETOPOSIDE; FUSION PROTEINS, BCR-ABL; HUMANS; K562 CELLS; LEUKEMIA; PROTO-ONCOGENE PROTEINS C-ABL; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 0034672449     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00497-4     Document Type: Article

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