Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor α in a calcium-sensitive manner

Biochemical Journal

Volumn 352, Issue 3, 2000, Pages 747-753

  Chee Wai Fong, ^a   Zhang, Y ^a   Soek Ying Neo, ^a   Lin, S C ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Cytokine function; Gene expression; T cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIMYCIN; CALCINEURIN; CYCLOSPORIN A; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA; NUCLEAR FACTOR; PROTEIN KINASE C INHIBITOR; PROTEIN RGS16; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TACROLIMUS; THAPSIGARGIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; LEUKEMIA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

ANDROSTADIENES; BUCLADESINE; CALCIMYCIN; CALCINEURIN; CALCIUM; CALCIUM SIGNALING; CYCLOSPORINE; DNA-BINDING PROTEINS; EGTAZIC ACID; ENZYME ACTIVATION; HUMANS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROTEIN KINASE C; PROTEINS; RGS PROTEINS; RNA, MESSENGER; TACROLIMUS; TETRADECANOYLPHORBOL ACETATE; THAPSIGARGIN; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0034672353     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3520747     Document Type: Article

References (34)

1. RGS proteins and signaling by heterotrimeric G proteins
2. Mammalian RGS proteins: Barbarians at the gate
3. Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones
4. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
5. Isolation and characterization of a novel B cell activation gene
6. A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells
7. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast
8. RGS·r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling
9. The core domain of RGS16 retains G-protein binding and GAP activity in vitro, but is not functional in vivo
10. RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor
11. Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes
12. Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling
13. The membrane association domain of RGS16 contains unique amphipathic features that are conserved in RGS4 and RGS5
14. Regulators of G-protein signaling (RGS) 1 and 16 are induced in response to bacterial lipopolysaccharide and stimulate c-los promoter expression
15. Muscarinic receptor stimulation increases regulators of G-protein signaling 2 mRNA levels through a protein kinase C-dependent mechanism
16. Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Galphaq proteins in the adult rat brain
17. Extraction, purification, and analysis of messenger RNA from eukaryotic cells
18. Effector pathways regulating T cell activation
19. Phorbol ester and diacylglycerol activation of native protein kinase C species from various tissues
20. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
21. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
22. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes
23. 2+ entry in hepatocytes
24. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
25. Calcineurin: Not just a simple protein phosphatase
26. A human T-cell line resistant to cytopathic effects of the human immunodeficiency virus (HIV)
27. Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: Ligand binding, biological activity, and HIV-1 infectivity
28. Regulator of G protein signaling 1 (RGS1) markedly impairs gialpha signaling responses of B lymphocytes
29. Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function
30. Common and distinct signaling pathways mediate the induction of TNF-alpha and IL-5 in IgE plus antigen-stimulated mast cells
31. Alterations in calcium signaling and cellular responses in septic injury
32. RGS mRNA expression in rat striatum: Modulation by dopamine receptors and effects of repeated amphetamine administration
33. Regulation of RGS mRNAs by cAMP in PC12 cells
34. RGS proteins determine signaling specificity of Gq-coupled receptors