Neonatal exposure to a self-peptide-immunoglobulin chimera circumvents the use of adjuvant and confers resistance to autoimmune disease by a novel mechanism involving interleukin 4 lymph node deviation and interferon γ- mediated splenic anergy

Journal of Experimental Medicine

Volumn 188, Issue 11, 1998, Pages 2007-2017

  Min, Booki ^a   Legge, Kevin L ^a   Pack, Christopher ^a   Zaghouani, Habib ^a,b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b M409 Walters Life Sciences Bldg ^*  (United States)

Author keywords

Anergy; Antigen delivery; Autoimmunity; Deviation; Neonatal tolerance

Indexed keywords

FC RECEPTOR; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 12; INTERLEUKIN 4; PROTEOLIPID PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; CHIMERA; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; AUTOANTIGENS; AUTOIMMUNE DISEASES; IMMUNE TOLERANCE; IMMUNOGLOBULINS; INTERFERON TYPE II; INTERLEUKIN-4; LYMPH NODES; MICE; PEPTIDES; RECOMBINANT FUSION PROTEINS; SPLEEN;

EID: 0031743403     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.11.2007     Document Type: Article

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