Metabolism of styrene-7,8-oxide in human liver in Vitro: Interindividual variation and stereochemistry

Toxicology and Applied Pharmacology

Volumn 169, Issue 1, 2000, Pages 52-58

  Wenker, Mira A M ^a   Kežić, Sanja ^a   Monster, Aart C ^a   de Wolff, Frederik A ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Enantiomers; Epoxide hydrolase; Interindividual variation; Metabolism; Stereoselectivity; Styrene; Styrene oxide

Indexed keywords

DIMETHYLNITROSAMINE DEMETHYLASE; EPOXIDE HYDROLASE; STYRENE; STYRENE OXIDE;

ADULT; ALCOHOL CONSUMPTION; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG DETOXIFICATION; DRUG HYDROLYSIS; DRUG INHIBITION; DRUG METABOLISM; ENANTIOMER; ENZYME ACTIVITY; ENZYME POLYMORPHISM; ENZYME SPECIFICITY; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; LIVER METABOLISM; MALE; METABOLIC INHIBITION; MICHAELIS MENTEN KINETICS; REACTION TIME; SMOKING; STEREOSPECIFICITY;

SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0034669038     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.9038     Document Type: Article

References (34)

1. Kinetic and chemical mechanism of epoxide hydrolase
2. The genetic toxicology of styrene and styrene oxide
3. Substrate enantioselection in the microsomal epoxide hydrolase catalyzed hydrolysis of monosubstituted oxiranes. Effect of branching of alkyl chains
4. Substrate enantioselectivity in the rabbit liver microsomal epoxide hydrolase catalyzed hydrolysis of trans and cis 1-phenylpropene oxides. A comparison with styrene oxide
5. Senescent changes in rodent hepatic epoxide metabolism
6. Metabolism of styrene oxide to styrene glycol by mouse liver and lung
7. Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic Pc 12 cells
8. Stereoselectivity of styrene oxidation in microsomes and in purified cytochrome P-450 enzymes from rat liver
9. Pneumotoxicity and hepatotoxicity of styrene and styrene oxide
10. Oxidation of toxic and carcinogenic chemicals by human cytochrome P450 enzymes
11. Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples
12. Human microsomal epoxide hydrolase: Genetic polymorphism and functional expression in vitro of amino acid variants
13. Human hepatic microsomal epoxide hydrolase: Comparative analysis of polymorphic expression
14. Styrene-7,8-oxide
15. Sub-chronic effects of styrene and styrene oxide on lipid peroxidation and the metabolism of glutathione in rat liver and brain
16. Age-related changes in the activities of epoxide hydrolases in different tissues of mice
17. Assessment of the neurotoxicity of styrene, styrene oxide, and styrene glycol in primary cultures of motor and sensory neurons
18. The catalytic mechanism of microsomal epoxide hydrolase involves an ester intermediate
19. Rat and mouse forestomach tumors induced by chronic oral administration of styrene oxide
20. Drug metabolism in man and its relationship to that in three rodent species: Monooxygenase, epoxide hydrolase and glutathione S-transferase activities in subcellular fractions of lung and liver
21. In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse, and human
22. Interindividual variations in the activities of cytosolic and microsomal epoxide hydrolase in human liver
23. Mutagenicity of (R) and (S) styrene 7,8-oxide and the intermediary mercapturic acid metabolites formed from styrene 7,8-oxide
24. A carcinogenicity study of styrene-7,8-oxide in rats
25. Human microsomal epoxide hydrolase: 5'-Flanking region genetic polymorphisms
26. Chirality-dependent DNA reactivity as the possible cause of the differential mutagenicity of the two components in an enantiomeric pair of epoxides
27. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
28. Review of the metabolic fate of styrene
29. Human liver microsomal epoxide hydrolase. Correlaticn of immunochemical quantitation with catalytic activity
30. Effect ofs styrene oxide on rat brain glutathione
31. Studies on metabolism and toxicity of styrene - VI. Regioselectivity in glutathione S-conjugation and hydrolysis of racemic, R- and S-phenyloxiranes in rat liver
32. Stereochemistry in the oxidative metabolism of styrene by hepatic microsomes
33. Enantio- and regioselectivity in the epoxide-hydrolase-catalyzed ring opening of simple aliphatic oxiranes: Part I: Monoalkylsubstituted oxiranes
34. The effect of age on pathways of drug metabolism in human liver