Identification of conserved amino acids in murine B7-1IgV domain critical for CTLA4/CD28:B7 interaction by site-directed mutagenesis: A novel structural model of the binding site

Molecular Immunology

Volumn 35, Issue 4, 1998, Pages 215-225

  Guo, Y ^a   Wu, Y ^a   Kong, X ^a   Liu, Y ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

B7 CD28 CTLA4 T cell activation

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

AMINO ACID ANALYSIS; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; GENETIC CONSERVATION; IMMUNE RESPONSE; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; BINDING SITES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CONSERVED SEQUENCE; EPITOPES; IMMUNOCONJUGATES; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, TERTIARY;

ANIMALIA; MURINAE;

EID: 0031858511     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(98)00041-8     Document Type: Article

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