Using UvrABC nuclease to detect 7,12-dimethylbenz[a]anthracene anti- diol epoxide-DNA binding specificity in the mouse H-ras gene

Chemical Research in Toxicology

Volumn 9, Issue 8, 1996, Pages 1350-1354

  Chen, James X ^a   Kisleyou, Alexander S ^c   Harvey, Ronald G ^c   Slaga, Thomas J ^a   Morris, Rebecca J ^b   Tang, Moon Shong ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; EPOXIDE; GENE PRODUCT; NUCLEASE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CODON; DNA BINDING; DNA DETERMINATION; DNA SEQUENCE; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; MULTIGENE FAMILY; ONCOGENE RAS; SEQUENCE HOMOLOGY;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; AUTORADIOGRAPHY; BASE SEQUENCE; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDODEOXYRIBONUCLEASES; ESCHERICHIA COLI PROTEINS; GENES, RAS; MICE; MOLECULAR SEQUENCE DATA;

EID: 0029849185     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9601115     Document Type: Article

References (31)

1. Slaga, T. J., Gleaso, G. H., DiGiovanni, J., Sukumaran, K. B., and Harvey, R. G. (1979) Potent tumor initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz[a]anthracene in mouse skin. Cancer Res. 39, 1934-1936.
2. Bigger, C. A. H., Sawicki, J. T., Blake, D. M., Raymond, L. G., and Dipple, A. (1983) Products of binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse skin. Cancer Res. 43, 5647-5651.
3. Manam, S., Storer, R. D., Prahalada, S., Leander, K. R., Kraynak, A. R., Edwith, B. J., Van Zwieten, M. J., Bradley, M. O., and Nichols, W. W. (1992) Activation of the Ha-, Ki-, and N-ras gene in chemically induced liver tumors from CD-1 mice. Cancer Res. 52, 3347-3362.
4. DiGiovanni, J., Fisher E. P., and Sawyer, T. W. (1986) Kinetics of formation and disappearance of 7,12-dimethylbenz[a]anthracene: DNA adducts in mouse epidermis. Cancer Res. 46, 4400-4405.
5. Dipple, A., Pigott, M. A., Bigger, C. A. H., and Blake, D. M. (1984) Dimethylbenz[a]anthracene-DNA binding in mouse skin; response of different mouse strains and effects of various modifiers of carcinogenesis. Carcinogenesis 5, 1087-1090.
6. Bigger, C. A. H., Tomaszewski, J. E., and Dipple, A. (1980) Variation in route of microsomal activation of 7,12-dimethylbenz[a]anthracene with substrate concentration. Carcinogenesis 1, 15-20.
7. Bigger, C. A. H., Tomaszewski, J. E., Dipple, A., and Lake, R. S. (1980) Limitations of metabolic activation systems used with in vitro tests for carcinogens. Science (Washington, DC) 209, 503-505.
8. Cooper, C. S., Ribeiro, O., Hewer, A., Walsh, C., Grover, P. L., and Sims, P. (1980) Additional evidence for the involvement of the 3,4-diol 1,2-oxides in metabolic activation of 7,12-dimethylbenz[a]anthracene in mouse skin. Chem.-Biol. Interact. 29, 357-367.
9. Sawick, J. T., Moschel, R. C., and Dipple, A. (1983) Involvement of both syn- and anti-dihydrodiol-epoxides in the binding of 7,-12-dimethylbenz[a]anthracene to DNA in mouse embryo cell cultures. Cancer Res. 43, 3212-3218.
10. Vericat, J. A., Cheng, S. C., and Dipple, A. (1989) Absolute stereochemistry of the major 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse. Carcinogenesis 10, 567-570.
11. Balmain, A., Ramsden, M., Bowden, G.T., and Smith, J. (1984) Activation of the mouse cellular Harvey-ras gene in chemically induced being skin papillomas. Nature 307, 658-660.
12. Quintanilla, M., Brown, K., Ramsden, M., and Balmain, A. (1986) Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322, 78-80.
13. Quintanilla, M., Haddow, S., Jonas, D., Jaffe, D., Bowden, G.-T., and Balmain, A. (1991) Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo. Carcinogenesis 12, 1875-1881.
14. Bizub, D., Wood, A. W., and Skalka, A. M. (1986) Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycylic aromatic hydrocarbons. Proc. Natl. Acad. Sci. U.S.A. 83, 6048-6052.
15. Robles, A. I., Gimenez-Conti, I. B., Roop, D., Slaga, T. J., and Conti, C. J. (1993) Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]anthracene-induced hamster skin tumors. Mol. Carcinog. 7, 94-98.
16. Gimenez-Conti, I. B., Sharon, A. B., Stockman, S. L., Conti, C. J., and Slaga, T. J. (1992) Activating mutation of the Ha-ras gene in chemically induced tumors of the hamster cheek pouch. Mol. Carcinog. 5, 259-263.
17. Chen, J. X., Pao, A., Zheng, Y., Ye, X., Kisleyou, A., Morris, R., Slaga, T. J., Harvey, R., and Tang, M.-s. (1996) Sequence preference of 7,12-dimethylbenz[a]anthracene-syn-diol epoxide-DNA binding in mouse H-ras gene detected by UvrABC nucleases. Biochemistry 35, 9594-9602.
18. Balmain, A., and Brown, K. (1988) Oncogene activation in chemical carcinogenesis. Adv. Cancer Res. 51, 147-182.
19. Sukumar, S. (1990) An experimental analysis of cancer: Role of ras oncogenes in multistep carcinogenesis. Cancer Cell 2, 199-204.
20. Barbacid, M. (1987) Ras genes. Anna. Rev. Biochem. 56, 779-827.
21. Bos, J. L. (1989) Ras Oncogenes in human cancer: A review. Cancer Res. 49, 4682-4689.
22. Manam, S., Store, R. D., Prahalada, S., Leander, K. R., Kraynak, A. R., Hammermeister, C. L., Joslyn, D. J., Ledwith, B. J., Zweiten, M. J., Bradley, M. O., and Nichols, W. W. (1992) Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-mice. Mol. Carcinog. 6, 68-75.
23. Lee, H., and Harvey, R. G. (1986) Synthesis of the active diol epoxide metabolite of the potent carcinogenic hydrocarbon 7,12-dimethylbenz[a]anthrene. J. Org. Chem. 51, 3502-3507.
24. Maxam, A. M., and Gilbert, W. (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65, 499.
25. Tang, M.-s., Pierce, J. R., Doisy, R. P., Nazimiec, M. E., and MacLeod, M. C. (1992) Differences and similarities in the repair of two benzo[a]pyrene diol epoxide isomers induced DNA adducts by uvrA, uvrB, and uvrC gene products. Biochemistry 31, 8429.
26. Nazimiec, M. E., Grossman, L., and Tang, M.-s. (1992) A comparison of the rate of reaction and function of UVRB- and UVRAB-mediated anthramycin-N2-guanine-DNA repair. J. Biol. Chem. 267, 24716-24724.
27. Pierce, J. R., Case, R., and Tang, M.-s. (1989) Recognition and repair of 2-aminoflurene- and 2-(acetylamino)fluorene DNA adducts by UVRABC nuclease. Biochemistry 28, 5821-5826.
28. Tang, M.-s., Lee, C.-S., Doisy, R., Ross, L., Needham-VanDevanter, D. R., and Hurley, L. H. (1988) Recognition and repair of the CC-1065-(N3-adenine)-DNA adduct by the UvrABC nucleases. Biochemistry 27, 893-901.
29. Seeberg, E., and Steinum, A. L., Nordenskjold, M., Soderhall, S., and Jernstrom, B. (1983) Strand-break formation in DNA modified by benzo[a]pyrene diolepoxide. Quantitative cleavage by Escherichia coli UvrABC endonuclease. Mutat. Res. 112, 139-145.
30. Sancar, A., and Rupp, W. D. (1983) A novel repair enzyme: UvrABC excision nuclease of E. coli cuts a DNA strand on both sides of the damaged region. Cell 33, 249-60.
31. Cheng, S. C., Prakash, A. S., Pigott, M. A., Hilton, B. D., Lee, H., Harvey, R. G., and Dipple, A. (1988) A metabolite of the carcinogen 7,12-dimethylbenz[a]anthracene that reacts predominantly with adenine residues in DNA. Carcinogenesis 9, 1721-1723.