Protective effect of MK-801 on the anoxia-aglycemia induced damage in the fluorocitrate-treated hippocampal slice of the rat

Brain Research

Volumn 732, Issue 1-2, 1996, Pages 232-236

  Nakanishi, Hiroshi ^a   Kawachi, Akio ^b,c   Okada, Mitsuko ^b   Fujiwara, Michihiro ^b   Yamamoto, Kenji ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

aglycemia; anoxia; astrocyte; CA1 pyramidal cell; fluorocitrate; hippocampal slice; MK 801; rat

Indexed keywords

DIZOCILPINE; FLUOROCITRIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT;

ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HYPOGLYCEMIA; MALE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030565501     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00689-0     Document Type: Article

References (23)

1. Benveniste H., Drejer J., Schousboe A., Diemer N.H. Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1984;1369-1374.
2. Choi D.W. Cerebral hypoxia: some new approaches and unanswered questions. J. Neurosci. 10:1990;2493-2501.
3. Clark G.D., Rothman S.M. Blockade of excitatory amino acid receptors protects anoxic hippocampal slices. Neuroscience. 21:1987;665-671.
4. Clarke D.D. Fluoroacetate and fluorocitrate: mechanism of action, Neurochem. Res. 16:1991;1055-1058.
5. Hernándéz-Cáceres J., Macias-González R., Brožek G., Bureš J. Systemic ketamine blocks cortical spreading depression but does not delay the onset of terminal anoxic depolarization in rats. Brain Res. 437:1987;360-364.
6. Henn F.A., Goldstein M.N., Hamberger A. Uptake of the neurotransmitter candidate glutamate by glia. Nature. 249:1974;663-664.
7. Hertz L. An intense potassium uptake into astrocytes, its further enhancement by high concentrations of potassium and its possible involvement in potassium homeostasis at the cellular level. Brain Res. 145:1978;202-208.
8. Huang R., Hertz L. Effect of anoxia on glutamate formation from glutamine in cultured neurons: dependence on neuronal subtype. Brain Res. 660:1994;129-137.
9. Huang R., Shuaib A., Hertz L. Glutamate uptake and glutamate content in primary cultures of mouse astrocytes during anoxia, substrate deprivation and simulated ischemia under normothermic and hypothermic conditions. Brain Res. 618:1993;643-651.
10. Kass I.S., Chambergs G., Cottrell J.E. The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate gyrus and CA1 pyramidal cells in the rat hippocampal slice. Exp. Neurol. 103:1989;116-122.
11. Keyser D.O., Pellmar T.C. Synaptic transmission in the hippocampus: critical role for glial cells. Glia. 10:1994;237-243.
12. Kral T., Luhmann H.J., Mittmann T., Heinemann U. Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia. Brain Res. 612:1993;278-288.
13. Lauritzen M., Hansen A.J. The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression. J. Cereb. Blood Flow Metab. 12:1992;223-229.
14. 2+-deficient mice. Eur. J. Pharmacol. 204:1991;29-34.
15. Papas S., Crepel V., Ben-Ari Y. The NMDA receptor contributes to anoxic aglycemic induced irreversible inhibition of synaptic transmission. Brain Res. 607:1993;54-60.
16. Paulsen R.E., Contestabile A., Vallani L., Fonnum F. An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: the use of fluolocitrate. J. Neurochem. 48:1987;1377-1385.
17. Rader R.K., Lanthorn T.H. Experimental ischemia induces a persistent depolarization blocked by decreased calcium and NMDA antagonists. Neurosci. Lett. 99:1989;125-130.
18. Siesjö B.K., Bengtsson F. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spread depression: a unifying hypothesis. J. Cereb. Blood Flow Metab. 9:1989;127-140.
19. Shousboe A., Svenneby G., Hertz L. Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres. J. Neurochem. 29:1977;999-1005.
20. +: role of glia. Brain Res. 542:1991;259-265.
21. Szerb J.C., Issekutz B. Increase in the stimulation-induced overflow of glutamate by fluorocitrate, a selective inhibitor of the glial tricarboxylic cycle. Brain Res. 410:1987;116-120.
22. Vibulsreth S., Hefti F., Ginsber M.D., Dietrich W.D., Bustro R. Astrocytes protect cultured neurons from degeneration induced by anoxia. Brain Res. 422:1987;303-311.
23. Walz W. Role of glial cells in the regulation of the brain ion microenvironment. Prog. Neurobiol. 33:1989;309-333.