Insulin in w/o/w multiple emulsions: Biological activity after oral administration in normal and diabetic rats

Journal of Microencapsulation

Volumn 14, Issue 3, 1997, Pages 321-333

  Silva Cunha, A ^a   Grossiord, J L ^b   Puisieux, F ^b   Seiller, M ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIV PARIS SUD   (France)

Author keywords

Diabetic and normal rats; Glycemia; Insulin; Oral route; W o w multiple emulsion

Indexed keywords

INSULIN; ISUMAN RAPIDE; SOYBEAN OIL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DILUTION; DRUG ABSORPTION; DRUG ACTIVITY; DRUG RELEASE; EMULSION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0000156336     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.3109/02652049709051136     Document Type: Article

References (23)

1. ANWANA, A. B., and GARLAND, H. O., 1991, Intracellular dehydration in the rate made diabetic with streptozotocin: effects of infusion. Journal of Endocrinology, 128, 333-337.
2. BENDAYAN, M., ZIV, E., GINGRAS, D., BEN-SASSON, R., BARON, H., and KIDRON, M., 1994, Biochemical and morphocytochemical evidence for the intestinal absorption of insulin in control diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa. Diabetologia, 37, 119-126.
3. BROWN, L., MUNOZ, C., SIEMER, L., EDELMAN, E., and LANGER, R., 1986, Controlled release of insulin from polymer matrices. Control of diabetes in rats. Diabetes, 35, 692-697.
4. CHOUDHARI, K. B., LABHASETWAR, V., and DORLE, A. K., 1994, Liposomes as a carrier for oral administration of insulin: effect of formulation factors. Journal of Microencapsulation, 11, 319-325.
5. DAMGÉ, C., Michel, C., Aprahamian, M., and COUVREUR, P., 1988, New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes, 37, 246-251.
6. ENGEL, R. H., RIGGI, S. J., and FAHRENBACH, M. J., 1968, Insulin: intestinal absorption as water-in-oil-water emulsions. Nature, 219, 856-857.
7. JEFFERSON, L. S., LIAO, W. S. L., PEAVY, D. E., MILLER, T. B., APPEL, M. C., and TAYLOR, M., 1983, Diabetes-induced alterations in liver protein synthesis. Changes in the relative abundance of mRNAs for albumin and other plasma proteins. Journal of Biological Chemistry, 258, 1369-1365.
8. LIN, S. Y., WU, W. H., and LUI, W. Y., 1992, In vitro release, pharmacokinetic and tissue distribution studies of doxorubicin hydrochloride (Adriamycin HCl®) encapsulated in Lipiodolized w/o emulsions and w/o/w multiple emulsions. Pharmazie, 47, 439-443.
9. MICHEL, C., APRAHAMIAN, M., DEFONTAINE, L., COUVREUR, P., and DAMGE, C., 1991, The effect of site administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in the diabetic rats. Journal of Pharmacy and Pharmacology, 43, 1-5.
10. MESIHA, M., PLAKOGIANNIS, F., and VEJOSOTH, S., 1994, Enhanced oral absorption of insulin from desolvated fatty acid-sodium glycocholate emulsions. International Journal of Pharmaceutics, 111, 213-216.
11. MORISHITA, I., MORISHITA, M., TAKAYAMA, K., MACHIDA, Y., and NAGAI, T., 1992, Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats. International Journal of Pharmaceutics, 78, 9-16.
12. 2EDTA and sodium glycocholate on intestinal absorption of insulin. Biological and Pharmaceutical Bulletin, 16, 68-72.
13. OMOTOSHO, J. A., WHATELEY, T. L., and FLORENCE, A. T., 1989, Release of 5-fluorouracil from intramuscular w/o/w multiple emulsions. Biopharmaceutics and Drug Disposition, 10, 257-268.
14. SCHILLING, R. J., and MITRA, A. K., 1990, Intestinal mucosal transport of insulin. International Journal of Pharmaceutics, 62, 53-64.
15. SHAO, Z., LI, Y., KRISHNAMOORTHY, R., CHERMAK, T., and MITRA, A. K., 1993, Differential effects of anionic, cationic, nonionic, and physiologic surfactants on the dissociation, alpha-chymotryptic degradation, and enteral absorption of insulin hexamers. Pharmaceutical Research, 10, 243-251.
16. SHICHIRI, M., SHIMIZU, Y., YOSHIDA, Y., KAWAMORI, R., FUKYCHI, M., SHIGETA, Y., and ABE, H., 1974, Enteral absorption of water-in-oil-in-water insulin emulsions in rabbits. Diabetologia, 10, 317-321.
17. SHICHIRI, M., KAWAMORI, R., YOSHIDA, M., ETANI, N., HOSHI, M., IZUMI, K., SHIGETA, Y., and ABE, H., 1975, Short-term treatment of alloxan-diabetic rats with intrajejunal administration of water-in-oil-in-water insulin emulsions. Diabetes, 24, 971-76.
18. SHICHIRI, M., KAWAMORI, R., GORIYA, Y., OJI, N., SHIGETA, Y., and ABE, H., 1976, A model for evaluation of the peroral insulin therapy: short-term treatment of alloxan diabetic rats with oral water-in-oil-in-water insulin emissions. Endocrinologia Japonica, 23, 493-498.
19. SILVA CUNHA, A., GROSSIORD, J. L., PUISIEUX, F., and SEILLER, M., 1997, Insulin in w/o/w multiple emulsions: preparation, characterization and determination of stability towards proteases in vitro. Journal of Microencapsulation, 14, 311-319.
20. TOUITOU, E., and RUBINSTEIN, A., 1986, Targeted enteral delivery of insulin to rats. International Journal of Pharmaceutics, 30, 95-99.
21. WU, Q., PING, Q., and LIU, G., 1990, Blood glucose-reduced efficiency of insulin multiple emulsion for experimental diabetic mice by oral administration. Zhongguo Yiyao, 21, 445-448.
22. YOSHIDA, T., IKEUCHI, K., HASHIDA, M., MURANISHI, S., and SEZAKI, H., 1982, Prolonged release of bleomycin from parenteral gelatin sphere-in-oil-water multiple emulsion. Chemical and Pharmaceutical Bulletin, 30, 1408-1415.
23. ZIV, E., LIOR, O., and KIDRON, M., 1987, Absorption of protein via the intestinal wall. A quantitative model. Biochemical Pharmaceutics, 36, 1035-1039.