Pepsin-mediated processing of the cytoplasmic histone H2A to strong antimicrobial peptide buforin I

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3268-3274

  Hun Sik Kim, ^a   Yoon, H ^a   Minn, I ^a   Park, C B ^a   Won Taek Lee, ^a   Zasioff, M ^a   Sun Chang Kim, ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BUFORIN I; GASTRICSIN; GASTROINTESTINAL POLYPEPTIDE; HISTONE H2A; PEPSIN A; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOPLASM; GASTROINTESTINAL TRACT; HOST RESISTANCE; INTESTINE EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECRETION; STOMACH GLAND; TOAD;

BUFO BUFO;

EID: 0034665099     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3268     Document Type: Article

References (45)

1. Peptides as weapons against microorganisms in the chemical defense system of vertebrates
2. Decreased gastric acid secretion and bacterial colonization of the stomach in severely malnourished Bangladeshi children
3. Potential role of epithelial cell-derived histone H1 protein in innate antimicrobial defense in the human gastrointestinal tract
4. Acid resistance in enteric bacteria
5. The relationship between acid stress responses and virulence in Salmonella typhimurium and Listeria monocytogenes
6. Peptide antibiotics and their role in innate immunity. Annu
7. Peptide antibiotics
8. Paneth cell defensins: Endogenous peptide components of intestinal host defense
9. Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds
10. β-Defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
11. Chemical synthesis and enzymic processing of precursor forms of cecropins A and B
12. Bactenecins, defense polypeptides of bovine neutrophils, are generated from precursor molecules stored in the large granules
13. Posttranslational processing of defensins in immature human myeloid cells
14. Regulation of intestinal a-defensin activation by the metalloproteinase matrilysin in innate host defense
15. A novel antimicrobial peptide from Bufo bufo gargarizans
16. cDNA cloning and characterization of buforin I, an antimicrobial peptide: A cleavage product of histone H2A
17. Ultrasensitive assays for endogenous antimicrobial polypeptides
18. Structure and binding properties of monoclonal antibodies to core histones from autoimmune mice
19. Purification, characterization, and amino acid sequences of pepsinogens and pepsins from the esophageal mucosa of bullfrog (Rana catesbeiana)
20. Human pepsinogen C (progastricsin)
21. Purification and characterization of pepsinogens and a unique pepsin from rat stomach
22. Peptic ulcer: The many proteinases of aggression
23. Gastric proteinases: Structure, function, evolution and mechanism of action
24. Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 A resolution
25. Mapping of linear histone regions exposed at the surface of the nucleosome in solution
26. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates
27. Analysis of nucleosome assembly and histone exchange using antibodies specific for acetylated H4
28. Antibodies specific to acetylated histories document the existence of deposition- and transcription-related histone acetylation in Tetrahymena
29. Acetylation of histone H2A,H2B dimers facilitates transcription
30. G~ and S phase mammalian cells synthesize histones at equivalent rates
31. Histones in transit: Cytosolic histone complexes and diacetylation of H4 during nucleosome assembly in human cells
32. Antimicrobial proteins of murine macrophages
33. Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells
34. Cytoplasmic pool of histone HI in mammalian cells
35. A naturally occurring polyclonal B cell activator of normal and autoantibody responses
36. Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cells
37. Anti-histone autoantibodies react specifically with the B cell surface
38. Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane
39. Bactericidal action of histone
40. Identification and characterization of heparan sulfate-binding proteins from human lung carcinoma cells
41. Histone H4-related osteogenic growth peptide (OGP): A novel circulating stimulator of osteoblastic activity
42. Stabilization of sea urchin flagellar microtubules by histone H1
43. Extracellularly occurring histone H 1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages
44. Antimicrobial peptides in the stomach of Xenopus laevis
45. Structure, synthesis, and activity of dermaseptin b, a novel vertebrate defensive peptide from frog skin: Relationship with adenoregulin