High prevalence of protein-dependent and protein-independent antiphospholipid and other autoantibodies in healthy elders

Thrombosis Research

Volumn 99, Issue 2, 2000, Pages 129-133

  Richaud Patin, Yvonne ^a   Cabiedes, Javier ^a   Jakez Ocampo, Juan ^a   Vidaller, Antonio ^b   Llorente, Luis ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b L'Hospitalet de Lloibregat   (Spain)

Author keywords

Aging; Antiphospholipid antibodies; Autoimmunity

Indexed keywords

AUTOANTIBODY; PHOSPHOLIPID ANTIBODY;

AGED; AGING; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PREVALENCE; PRIORITY JOURNAL;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANTIBODIES, ANTICARDIOLIPIN; ANTIBODIES, ANTIPHOSPHOLIPID; ANTICOAGULANTS; AUTOANTIBODIES; AUTOIMMUNITY; BETA 2-GLYCOPROTEIN I; DNA; FEMALE; GLYCOPROTEINS; HUMANS; PREVALENCE; VASCULAR DISEASES;

EID: 0034661338     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00243-7     Document Type: Article

References (32)

1. Hijmans W., Radl J., Bottazzo G.F., Doniach D. Autoantibodies in highly aged humans. Mech Ageing Dev. 26:1984;83-89.
2. Ruffatti A., Calligaro A., Del Ross T., Bertoli M.T., Doria A., Rossi L., Todesco S. Anti-double-stranded DNA antibodies in the healthy elderly. prevalence and characteristics J Clin Immunol. 10:1990;300-303.
3. Miller R.A. The aging immune system. Primer and prospectus Science. 273:1996;70-74.
4. Fillit H. Clinical immunology of aging. Rev Clin Gerontol. 4:1994;187-197.
5. Makidonan T., Kay M.M.B. Age influence of the immune system. Adv Immunol. 29:1980;293-299.
6. 2-glycoprotein I (apolipoprotein H) Proc Natl Acad Sci USA. 87:1990;4120-4124.
7. Galli M., Comfurius P., Maassen C., Hemker H.C., DeBaetss M.H., Van Breda-Vriesman P.J.C., Barbui T., Zwaal R.F.A., Bevers E.M. Anticardiolipin antibodies (CA) directed not to cardiolipin but to a plasma protein cofactor. Lancet. 335:1990;1544-1547.
8. Sammaritano L.R., Lockshin M.D., Gharavi A.E. Antiphospholipid antibodies differ in aPL cofactor requirements. Lupus. 1:1992;83-90.
9. 2-glycoprotein 1. a specific marker for the antiphospholipid syndrome Clin Exp Immunol. 109:1997;304-309.
10. 2-glycoprotein I, anti-prothrombin antibodies, and lupus anticoagulant in patients with systemic lupus erythematosus with a history of thrombosis. J Rheumatol. 24:1997;1710-1715.
11. 2-glycoprotein-I but no antibodies detectable in standard phospholipid assays Am J Med. 101:1996;472-481.
12. 2-glycoprotein-I but no antibodies detectable in standard antiphospholipid assay J Rheumatol. 24:1997;1545-1551.
13. Hörkkö S., Miller E., Dudl E., Reaven P., Curtiss L.K., Zvaifler N., Terkeltaub R., Pierangeli S.S., Ware Branch D., Palinski W., Witztum J.L. Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein. J Clin Inv. 98:1996;815-825.
14. Petri M. 1998 update on antiphospholipid antibodies. Curr Opin Rheumatol. 10:1998;426-430.
15. Shoenfeld Y., Haratz D., George J. Atherosclerosis and the antiphospholipid syndrome:A link unravelled? Lupus. 7:1998;140-143.
16. George J., Afek A., Gilburd B., Levy Y., Blank M., Kopolovic J., Harats D., Shoenfeld Y. Atherosclerosis in LDL-receptor knockout mice is accelerated by immunization with anticardiolipin antibodies. Lupus. 6:1997;723-729.
17. Atsumi T., Khamashta M.A., Andujar C., Leandro M.J., Amengual O., Ames P.R.J., Hughes G.R.V. Elevated plasma lipoprotein (a) level and its association with impaired fibrinolysis in patients with antiphospholipid syndrome. J Rheumatol. 25:1998;69-73.
18. Specker C., Rademacher J., Sohngen D., Sitzer M., Janda I., Siebler M., Steinmetz H., Schneider M. Cerebrel microemboly in patients with antiphospholipid syndrome. Lupus. 6:1997;638-644.
19. Matsuura E., Igarashi Y., Fujimoto M., Ichikawa K., Suzuki T., Sumida T., Yasuda T., Koike T. Heterogeneity of anti cardiolipin antibodies defined by anticardiolipin cofactor. J Immunol. 248:1992;3885-3891.
20. Ruíz-Argüelles A., Presno-Bernal M. Demonstration of a cross-reactive idiotype (IdRQ) in rheumatoid factors from patients with rheumatoid arthritis but not in rheumatoid factors from healthy, aged subjects. Arthritis Rheum. 32:1989;134-138.
21. Avrameas S., Ternynck T. The natural autoantibodies system. Mol Immunol. 30:1993;1133-1142.
22. Djavad N., Bas S., Shi X., Schwager J., Jeannet M., Vischer T., Roosnek E. Comparison of rheumatoid factors of rheumatoid arthritis patients, of individuals with mycobacterial infections and of normal controls. evidence for maturation in the absence of an autoimmune response Eur J Immunol. 26:1996;2480-2486.
23. Walsh S.J., Rau L.M. Excess autoimmune mortality among school teachers. Arthritis Rheum. 42:1999;S302-1387.
24. Loizou S., Cazabon J.K., Walport M.J., Tait D., So A.K. Similarities of specificity and cofactor dependence in serum antiphospholipid antibodies from patients with human parvovirus B19 infection and from those with systemic lupus erythematosus. Arthritis Rheum. 40:1997;103-108.
25. Asherson R.A., Shoenfeld Y. The role of infection in the pathogenesis of catastrophic APS-Molecular mimicry? J Rheumatol. 27:2000;12-14.
26. Rojas-Rodríguez J., García-Carrasco M., Ramos-Casals M., Enríquez-Coronel G., Colchero C., Cervera R., Font J. Catastrophic antiphospholipid syndrome. Clinical description and triggering factors in 8 patients J Rheumatol. 27:2000;238-240.
27. Hojnik M., Gilburd B., Ziporen L., Blank M., Tomer Y., Scheinberg M.A., Tincani A., Rozman B., Shoenfeld Y. Anticardiolipin antibodies in infections are heterogeneous in their dependency on β2-glycoprotein I. analysis of cardiolipin antibodies in leprosy Lupus. 2:1994;515-521.
28. Llorente L., Zou W., Levy Y., Richaud-Patin Y., Wijdenes J., Alcocer-Varela J., Morel-Fourrier B., Brouet J.C., Alarcón-Segovia D., Galanaud P., Emilie D. Role of interleukin 10 in the B cell hyperactivity and autoantibody production of systemic lupus erythematosus. J Exp Med. 181:1995;839-844.
29. Llorente L., Richaud-Patin Y., Alvarado C., Vidaller A., Jakez-Ocampo J. Autoantibody production in healthy elderly people is not promoted by interleukin-10 although this cytokine is expressed in them by a peculiar CD8+ CD3+ large granular cell subpopulation. Scand J Immunol. 45:1997;401-407.
30. Richaud-Patin Y., Villa A.R. Autoantibodies, mortality and ageing. Med Hypotheses. 44:1995;10-15.
31. Llorente L., Richaud-Patin Y., Díaz-Borjón A., Jakez-Ocampo J., Alvarado de la Barrera C. Increased collagenase and dipeptidyl peptidase I activity in leukocytes from healthy elderly people. Clin Exp Immunol. 116:1999;425-429.
32. Grabar P. Hypothesis. Autoantibodies and immunological theories. an analytical review Clin Immunol Immunopathol. 4:1975;453-466.