Bone tissue specific transcriptional control: Options for targeting gene therapy to the skeleton

Cancer

Volumn 88, Issue 12 SUPPL., 2000, Pages 2899-2902

  Stein, Gary S ^a   Lian, Jane B ^a   Stein, Janet L ^a   Van Wijnen, André J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AML CBF; Carcinoma; Gene expression; Intranuclear targeting; Transplantation

Indexed keywords

OSTEOCALCIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CBFA AML; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BONE METASTASIS; CANCER THERAPY; CONFERENCE PAPER; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION REGULATION;

EID: 0034660340     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20000615)88:12+<2899::aid-cncr3>3.0.co;2-o     Document Type: Conference Paper

References (15)

1. Rahman S, Oberdorf A, Montecino M, Tanhauser SM, Lian JB, Stein GS, et al. Multiple copies of the bone-specific osteocalcin gene in mouse and rat. Endocrinology 1993;133: 3050-3.
2. Lian JB, Stein GS, Stein JL, van Wijnen AJ. Regulated expression of the bone-specific osteocalcin gene by vitamins and hormones. In: Litwack G, editor. Vitamins and hormones, vol 55. San Diego: Academic Press, 1998:443-509.
3. Baker AR, Hollingshead PG, Pitts-Meek S, Hansen S, Taylor R, Stewart TA. Osteoblast-specific expression of growth hormone stimulates bone growth in transgenic mice. Mol Cell Biol 1992;12:5541-7.
4. Kesterson RA, Stanley L, DeMayo F, Finegold M, Pike JW. The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic mice. Mol Endocrinol 1993;7:462-7.
5. Frenkel B, Capparelli C, van Auken M, Bryan J, Stein JL, Stein GS, et al. Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex. Endocrinology 1997;138:2109-16.
6. Sims NA, White CP, Sunn KL, Thomas GP, Drummond ML, Morrison NA, et al. Human and murine osteocalcin gene expression: conserved tissue restricted expression and divergent responses to 1,25-dihydroxyvitamin D3 in vivo. Mol Endocrinol 1997;11:1695-708.
7. Ko SC, Cheon J, Kao C, Gotoh A, Shirakawa T, Sikes RA, et al. Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. Cancer Res 1996;56:4614-9.
8. Desbois C, Hogue DA, Karsenty G. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J Biol Chem 1994;269: 1183-90.
9. Hou Z, Nguyen Q, Frenkel B, Nilsson SK, Milne M, van Wijnen AJ, et al. Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. Proc Natl Acad Sci USA 1999;96:7294-9.
10. Nilsson SK, Dooner MS, Weier HU, Frenkel B, Lian JB, Stein GS, et al. Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J Exp Med 1999;189:729-34.
11. Zeng C, van Wijnen AJ, Stein JL, Meyers S, Sun W, Shopland L, et al. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBFα transcription factors. Proc Natl Acad Sci USA 1997;94:6746-51.
12. Zeng C, McNeil S, Pockwinse S, Nickerson JA, Shopland L, Lawrence JB, et al. Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains. Proc Natl Acad Sci USA 1998;95:1585-9.
13. Tang L, Guo B, Javed A, Choi J-Y, Hiebert S, Lian JB, et al. Crystal structure of the nuclear matrix targeting signal of the transcription factor AML-1/PEBP2αB/CBFA2. J Biol Chem 1999;274:33580-33586.
14. Tang L, Guo B, van Wijnen AJ, Lian JB, Stein JL, Stein GS, et al. Preliminary crystallographic study of the glutathione S-transferase fused with the nuclear matrix targeting signal of the transcription factor AML-1/CBFα2. J Struct Biol 1998; 123:83-5.
15. McNeil S, Zeng C, Harrington KS, Hiebert S, Lian JB, Stein JL, et al. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFα2 transcription factor. Proc Natl Acad Sci USA 1999;96:14882-7.