Pharmacokinetics of prolonged-release CPT-11-loaded microspheres in rats

Journal of Controlled Release

Volumn 66, Issue 2-3, 2000, Pages 159-175

  Machida, Yoshiaki ^a   Onishi, Hiraku ^b   Kurita, Akinobu ^c   Hata, Harumi ^b   Morikawa, Akinobu ^a   Machida, Yoshiharu ^b  

^a CANCER INSTITUTE HOSPITAL   (Japan)

^b HOSHI UNIVERSITY   (Japan)

^c YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

CPT 11; Drug release rate; Pharmacokinetics; Prolonged release CPT 11 loaded microspheres; SN 38

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; COPOLYMER; DRUG METABOLITE; IRINOTECAN; MICROSPHERE; OIL; POLYGLACTIN; POLYLACTIC ACID; WATER;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG RELEASE; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MODEL; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TECHNIQUE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; GLUCURONATES; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MODELS, BIOLOGICAL; RATS; RATS, WISTAR;

EID: 0034657131     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00267-9     Document Type: Article

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