Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display

Journal of Immunology

Volumn 164, Issue 6, 2000, Pages 3413-3419

  Rowley, Merrill J ^a   Scealy, Marita ^a   Whisstock, James C ^a   Jois, Jennifer A ^a   Wijeyewickrema, Lakshmi C ^a   Mackay, Ian R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; PYRUVATE DEHYDROGENASE COMPLEX;

ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MOLECULAR MIMICRY; PEPTIDE SYNTHESIS; PHAGE DISPLAY; PREDICTION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

EID: 0034653534     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.6.3413     Document Type: Article

References (25)

1. Laver, W. G., G. M. Air, R. G. Webster, and S. J. Smith-Gill. 1990. Epitopes on protein antigens: misconceptions and realities. Cell 61:553.
2. Hannum, C. H., M. Utlee, L. A. Matis, R. H. Schwartz, and E. Margoliash. 1982. The major B and T cell determinant on pigeon cytochrome c in B10.a mice. Adv. Exp. Med. Biol. 150:37.
3. Gershwin, M. E., and I. R. Mackay. 1991. Primary biliary cirrhosis: paradigm or paradox for autoimmunity. Gastroenterology 100:822.
4. Yeaman, S. J. 1989. The 2-oxo acid dehydrogenase complexes: recent advances. Biochem. J. 257:625.
5. Van de Water, J., M. E. Gershwin, P. Leung, A. Ansari, and R. L. Coppel. 1988. The autoepitope of the 74-Kd mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional suite of dihydrolipoamide acetyltransferase. J. Exp. Med. 167:1791.
6. Fussey, S. M. P., S. T. Ali, J. R. Guest, O. F. W. James, M. F. Bassendine, and S. J. Yeaman. 1990. Reactivity of primary biliary cirrhosis sera with Escherichia coli dihydrolipoamide acetyltransferase (E2p): characterization of the main immunogenic region. Proc. Natl. Acad. Sci. USA 87:3987.
7. Koike, K., H. Ishibashi, and M. Koike. 1998. Immunoreactivity of porcine heart dihydrolipoamide acetyl- and succinyl-transferases (PDC-E2, OGDC-E2) with primary biliary cirrhosis sera: characterization of the autoantigenic region and effects of enzymatic delipoylation and relipoylation. Hepatology 27:1467.
8. Tuaillon, N., C. Andre, J.-P. Briand, E. Penner, and S. Muller. 1992. A lipoyl synthetic octadecapeptide of dihydrolipoamide acetyltransferase specifically recognized by anti-M2 antibodies in primary biliary cirrhosis. J. Immunol. 148:445.
9. Scott, J. K., and G. P. Smith. 1990. Searching for peptide ligands with an epitope library. Science 249:386.
10. Luzzago, A., F. Felici, A. Tramontano, A. Pessi, and R. Cortese. 1993. Mimicking of discontinuous epitopes by phage-displayed peptides. I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene 128:51.
11. Felici, F., A. Luzzago, A. Folgori, and R. Cortese. 1993. Mimicking of discontinuous epitopes by phage-displayed peptides. II. Selection of clones recognized by a protective monoclonal antibody against the Bordella pertussis toxin from phage peptide libraries. Gene 128:21.
12. Cook, A. D., J. M. Davies, M. A. Myers, I. R. Mackay, and M. J. Rowley. 1998. Mimotopes identified by phage display for the monoclonal antibody CII-CI to type II collagen. J. Autoimmun. 11:205.
13. Osman A. A., H. Uhlig, B. Thamm, J. Schneider-Mergener, and T. Mothes. 1998. Use of the phage display technique for detection of epitopes recognized by polyclonal rabbit gliadin antibodies. FEBS Lett. 433:103.
14. Folgori A, R. Tafi, A. Meola, F. Felici, G. Galfré, R. Cortese, P. Monaci, and A. Nicosia. 1994. A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J. 13:2236.
15. Kaplan, M. M. 1996. Primary biliary cirrhosis. N. Engl J. Med. 316:521.
16. Rowley, M. J., T. Maeda, I. R. Mackay, B. E. Loveland, G. L. McMullen, G. Tribbick, and C. C. A. Bernard. 1992. Differing epitope selection of experimentally induced and natural antibodies to a disease-specific autoantigen, the E2 subunit of pyruvate dehydrogenase complex (PDC-E2). Int. Immunol. 4:1245.
17. Coppel, R. L., L. J. McNeilage, C. D. Suhr, J. Van de Water, T. W. Spithill, S. Whittingham, and M. E. Gershwin. 1988. Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase. Proc. Natl. Acad. Sci. USA 85:7317.
18. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Lab. Press, New York.
19. Teoh, K.-L., M. J. Rowley, H. Zafirakis, E. R. Dickson, R. H. Wiesner, M. E. Gershwin, and I. R. Mackay. 1984. Enzyme inhibitory autoantibodies to pyruvate dehydrogenase complex in primary biliary cirrhosis: applications of a semiautomated assay. Hepatology 20:1220.
20. Davies, J. M., M. Scealy, Y.-P. Cai, J. Whisstock, I. R. Mackay, and M. J. Rowley. 1999. Multiple alignment and sorting of peptides derived from phage displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes. Mol. Immunol. 36:659.
21. Sneath, P. H. A., and R. R. Sokal. 1973. Unweighted pair-group method using arithmetic averages. In Numerical Taxonomy: The Principles and Practice of Numerical Classification. P. H. A. Sneath, ed. Freeman, New York, p. 230.
22. Howard, M. J., C. Fuller, R. W. Broadhurst, R. N. Perham, J. G. Tang, J. Quinn, A. G. Diamond, and S. J. Yeaman. 1998. Three-dimensional structure of the major autoantigen in primary biliary cirrhosis. Gastroenterology 115:139.
23. Cha, S., P. S. C. Leung, J. Van de Water, K. Tsuneyama, R. E. Joplin, A. A. Ansari, Y. Nakanuma, P. L. Schatz, S. Cwirla, L. E. Fabris, et al. 1996. Random phage mimotopes recognized by monoclonal antibodies against the pyruvate dehydrogenase complex-E2 (PDC-E2) Proc. Natl. Acad. Sci. USA 93: 10949.
24. Leung, P. S. C., S. Cha, R. E. Joplin, C. Galperin, J. Van de Water, A. Ansari, R. L. Coppel, P. J. Schatz, S. Cwirla, L. E. Fabris, et al. 1996. Inhibition of PDC-E2 human combinatorial autoantibodies by peptide mimotopes, J. Autoimmun. 9:785.
25. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. Clustal W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions - specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673. http://www.infobiogen.Fr/docs/ClustalW/clustalw.html