Immunoreactivity of porcine heart dihydrolipoamide acetyland succinyl- transferases (PDC-E2, OGDC-E2) with primary biliary cirrhosis sera: Characterization of the autoantigenic region and effects of enzymatic delipoylation and relipoylation

Hepatology

Volumn 27, Issue 6, 1998, Pages 1467-1474

  Koike, Kichiko ^a   Ishibashi, Hlromi ^b   Koike, Masahiko ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; DIHYDROLIPOAMIDE ACETYLTRANSFERASE; DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE;

ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HEART MITOCHONDRION; HUMAN; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; SWINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; HUMANS; IMMUNODOMINANT EPITOPES; KETOGLUTARATE DEHYDROGENASE COMPLEX; LIVER CIRRHOSIS, BILIARY; MOLECULAR SEQUENCE DATA; PYRUVATE DEHYDROGENASE COMPLEX; SWINE;

EID: 0031748099     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270602     Document Type: Article

References (19)

1. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1987;316:521-528.
2. Walker JG, Doniach D, Roitt IM, Sherlock S. Serological tests in diagnosis of primary biliary cirrhosis. Lancet 1958;1:827-829.
3. Klatskin G, Kantor FS, Mitochondrial antibody in primary biliary cirrhosis and other diseases. Ann Intern Med 1972;77:533-541.
4. Kaplan MM, Gandolfo JV, Quaroni EG. An enzyme-linked immunosorbant assay (ELISA) for detecting antimitochondrial antibody. HEPATOLOGY 1984;4:727-730.
5. Berg PA, Doniach D, Roitt IM. Mitochondrial antibodies in primary biliary cirrhosis. J Exp Med 1967;126:277-290.
6. Berg PA, Klein R, Lindenborn-Fotinos J. Antimitochondrial antibodies in primary biliary cirrhosis. J Hepatol 1986;2:123-131.
7. Frazer IH, Mackay IR, Jordan TW, Whittingham S, Marzuki S. Reactivity of antimitochondrial autoantibodies in primary biliary cirrhosis: definition of two novel mitochondrial polypeptide autoantigens. J Immunol 1985;135:1739-1745.
8. Koike M, Koike K. Structure, assembly and function of mammalian a -keto acid dehydrogenase complexes. Adv Biophys 1976;9:187-227.
9. Yeaman SJ. The 2-oxoacid dehydrogenase complexes: recent advances. Biochem J 1989;257:625-632.
10. Gershwin ME, Mackay IR, Sturgess A, Coppel RL. Identification and specificity of an cDNA encoding 70 kD mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol 1987;138:3525-3531.
11. Van de Water J, Gershwin ME, Leung P, Ansari A, Coppel RL. The autoepitope of the 74 kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J Exp Med 1988;167:1791-1799.
12. Coppel RL, McNeilage LJ, Surh CD, Van de Water J, Spithill TW, Whittingham S, Gershwin ME. Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase. Proc Natl Acad Sci U S A 1988;85:7317-7321.
13. Yeaman SJ, Danner DJ, Mutimer DJ, Fussey SPM, James OFW, Bassendine ME Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens. Lancet 1988;1:1067-1070.
14. Fussey SPM, Guest JR, James OFW, Bassendine MF, Yeaman SJ. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci U S A 1988;85:8654-8658.
15. Surh CD, Danner DJ, Ahmed A, Coppel RL, Mackay IR, Dickson ER, Gershwin ME. Reactivity of PBC sera with a human fetal liver cDNA clone of branched chain alpha-keto acid dehydrogenase (BCKD) dihydrolipoamide acyltransferase, the 52 kD mitochondrial autoantigen. HEPATOLOGY 1988;141:2321-2324.
16. Surh CD, Coppel RL, Gershwin ME. Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, The major autoantigen of primary biliary cirrhosis. J Immunol 1990;144:3367-3374.
17. Leung PSC, Chuang DT, Wynn RM, Cha S, Danner DJ, Ansari A, Coppel RL, et al. Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope. HEPATOLOGY 1995;22:505-513.
18. Fussey SPM, Bassendine MF, James OFW, Yeaman SJ. Characterization of the reactivity of autoantibodies in primary biliary cirrhosis. FEBS Lett 1989;246:49-53.
19. Palmer JM, Bassendine MF, James OFW, Yeaman SJ. Human pyruvate dehydrogenase as an autoantigen in primary biliary cirrhosis. Clin Sci 1993;85:289-293.