Lys-Ala mutations of type I adenylyl cyclase result in altered susceptibility to inhibition by adenine nucleoside 3'-polyphosphates

Archives of Biochemistry and Biophysics

Volumn 374, Issue 2, 2000, Pages 389-394

  Shoshani, Ilana ^a   Bianchi, Glen ^a   Désaubry, Laurent ^a   Dessauer, Carmen W ^a   Johnson, Roger A ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

2',5' Dideoxy 3' ADP; 2',5' Dideoxy 3' ATP; 2',5' Dideoxyadenosine, 2',5' dideoxy 3' AMP; 2' Deoxy 3' ADP; 2' Deoxy 3' AMP; 2' Deoxy 3' ATP; 2' Deoxy Ado; 3' AMP; Adenylyl cyclase; Cyclic nucleotides; Nucleoside 3' polyphosphates; P site; Signal transduction

Indexed keywords

ADENINE NUCLEOTIDE DERIVATIVE; ADENOSINE PHOSPHATE; ADENYLATE CYCLASE; ALANINE; LYSINE; MUTANT PROTEIN; POLYPHOSPHATE;

ARTICLE; ENZYME CONFORMATION; ENZYME MECHANISM; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; WORM;

ARMY WORM;

EID: 0034652223     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1999.1612     Document Type: Article

References (20)

1. Johnson R. A., Yeung S.-M.H., Stübner D., Bushfield M., Shoshani I. Mol. Pharmacol. 35:1989;681-688.
2. Bushfield M., Shoshani I., Johnson R. A. Mol. Pharmacol. 38:1990;848-853.
3. Désaubry L., Shoshani I., Johnson R. A. J. Biol. Chem. 271:1996;2380-2382.
4. Désaubry L., Shoshani I., Johnson R. A. J. Biol. Chem. 271:1996;14028-14034.
5. Désaubry L., Johnson R. A. J. Biol. Chem. 273:1998;24972-24977.
6. Johnson R. A., Désaubry L., Bianchi G., Shoshani I., Lyons E. Jr., Taussig R., Watson P. A., Cali J. J., Krupinski J., Pieroni J. P., Iyengar R. J. Biol. Chem. 272:1997;8962-8966.
7. Johnson R. A., Shoshani I. J. Biol. Chem. 265:1990;11595-11600.
8. Londos C., Wolff J. Proc. Natl. Acad. Sci. USA. 74:1977;5482-5486.
9. Wolff J., Londos C., Cooper D. M. F. Adv. Cyclic Nucleotide Res. 14:1981;199-214.
10. Tang W.-J., Stanzel M., Gilman A. G. Biochemistry. 34:1995;14563-14572.
11. Zhang G., Lieu Y., Ruoho A. E., Hurley J. H. Nature. 386:1997;247-253.
12. Dessauer C. W., Gilman A. G. J. Biol. Chem. 272:1997;27787-27795.
13. Liu Y., Ruoho A. E., Rao V. D., Hurley J. H. Proc. Natl. Acad. Sci. USA. 94:1997;13414-13419.
14. Tesmer J. J. G., Sunahara R. K., Gilman A. G., Sprang S. R. Science. 278:1997;1907-1916.
15. Florio V. A., Ross E. M. Mol. Pharmacol. 24:1983;195-202.
16. Krupinski J., Coussen F., Bakalyar H. A., Tang W.-J., Feinstein P. G., Orth K., Slaughter C., Reed R. R., Gilman A. G. Science. 244:1989;1558-1564.
17. Tang W.-J., Krupinski J., Gilman A. G. J. Biol. Chem. 266:1991;8595-8603.
18. Taussig R., Quarmby L. M., Gilman A. G. J. Biol. Chem. 268:1993;9-12.
19. Johnson R. A., Salomon Y. Methods Enzymol. 195:1991;3-21.
20. Tesmer J. J. G., Sunahara R. K., Johnson R. A., Gosselin G., Gilman A. G., Sprang S. R. Science. 285:1999;756-760.