Unresponsive CD4+ T lymphocytes from Leishmania chagasi-infected mice increase cytokine production and mediate parasite killing after blockade of B7-1/CTLA-4 molecular pathway

Journal of Infectious Diseases

Volumn 178, Issue 6, 1998, Pages 1847-1851

  Gomes, Nitza A ^b   Barreto de Souza, Victor ^b   Wilson, Mary E ^b   DosReis, George A ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL KILLING; CELL PROLIFERATION; CYTOKINE PRODUCTION; HELPER CELL; LEISHMANIA CHAGASI; LEISHMANIASIS; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PARASITE CONTROL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; CHRONIC DISEASE; CRICETINAE; CYTOKINES; FEMALE; IMMUNOCONJUGATES; INTERLEUKIN-2; INTERLEUKIN-4; LEISHMANIASIS; LYMPHOCYTE ACTIVATION; MESOCRICETUS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES; TH1 CELLS;

EID: 0031766135     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314520     Document Type: Article

References (5)

1. Carvalho EM, Badaro R, Reed SG, Jones TC, Johnson WD. Absence of γ-interferon and interleukin 2 production during active visceral leishmaniasis. J Clin Invest 1985;76:2066-9.
2. Kaye PM, Curry AJ, Blackwell JM. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. J Immunol 1991;146:2763-70.
3. Murray HW, Stern JJ, Welte K, Rubin BY, Carriero SM, Nathan CF. Experimental visceral leishmaniasis: production of interleukin 2 and interferon-γ, tissue immune reaction, and response to treatment with interleukin 2 and interferon-γ. J Immunol 1987;138:2290-7.
4. Bluestone JA. Is CTLA-4 a master switch for peripheral T cell tolerance? J Immunol 1997;158:1989-93.
5. Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995;270:985-8.